-
Mashup Score: 18Emerging Medical Therapies for ALD and NAFLD - 4 month(s) ago
Your browser does not support the video tag. All Contents Copyright American College of Gastroenterology. All rights reserved. The contents of all material available on this website are copyrighted by ACG unless otherwise indicated. Content may not be reproduced, downloaded, disseminated, published, or transferred in any form or by any means, except with the prior written permission of
Source: universe.gi.orgCategories: General Medicine News, GastroenterologyTweet
-
Mashup Score: 2HBV Markers, Reactivation Do Not Impact Effectiveness of Direct-Acting Antivirals for HCV - 4 month(s) ago
Response to direct-acting antiviral therapy was similar between patients with and without HBV coinfection, with most patients completing the planned course of treatment and achieving SVR, even in the case of HBV reactivation.
Source: www.contagionlive.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 2HBV Markers, Reactivation Do Not Impact Effectiveness of Direct-Acting Antivirals for HCV - 4 month(s) ago
Response to direct-acting antiviral therapy was similar between patients with and without HBV coinfection, with most patients completing the planned course of treatment and achieving SVR, even in the case of HBV reactivation.
Source: www.contagionlive.comCategories: General Medicine News, Infectious DiseaseTweet
-
Mashup Score: 5
prophylaxis, as well as the management of acute variceal bleeding, to improve the management of PHT in HCC patients. Results: Recent therapeutic advances observed in the management of HCC, notably through the advent of immunotherapy, have led to a clear improvement in the survival of patients. The prevention of complications related to underlying cirrhosis, such as PHT and acute variceal bleeding, is now part of the management of HCC patients. The Baveno VII conference recently redefined screening and prophylaxis in patients with cirrhosis. However, data regarding the applicability of these criteria in patients with HCC have been sparse. From our point of view, the Baveno criteria are not appropriate to exclude high-risk esophageal varices (EV) in HCC patients, and endoscopy should be performed except in HCC patients with a liver stiffness measurement (LSM) ≥25 kPa, who should benefit from nonselective beta-blockers (NSSBs) without performing endoscopy. We are also in favor of using NS
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet
-
Mashup Score: 4
igens, resulting in immune-mediated tissue damage. ICI-associated hepatotoxicity usually manifests as hepatocellular enzyme elevation and may occur in 2%–25% of ICI-treated patients. Although ICI-associated hepatotoxicity is clinically and pathologically distinct from idiopathic autoimmune hepatitis, our understanding of its pathogenesis continues to evolve. Pending greater understanding of the pathophysiology, mainstay of management remains through treatment with high-dose corticosteroids. This approach works for many patients, but up to 30% of patients with high-grade hepatotoxicity may not respond to corticosteroids alone. Furthermore, atypical cholestatic presentations are increasingly recognized, and rare cases of fulminant hepatitis due to ICI hepatotoxicity have been reported. Optimal management for these challenging patients remains uncertain. Herein, we review the current understanding of pathogenesis of ICI-associated toxicities, with a focus on hepatotoxicity. Based on the e
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet
-
Mashup Score: 3Fibrosis Screening Can Promote Positive Lifestyle Changes - 4 month(s) ago
Sharing liver health results and lifestyle advice with those at risk for ALD and MASLD led to sustained improvements in alcohol intake, diet, and exercise for up to 2 years.
Source: www.medscape.comCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0Host genetic variation guides hepacivirus clearance,... : Hepatology - 4 month(s) ago
g hepatitis in typical strains of laboratory mice, which resolves in 2 weeks. The Collaborative Cross (CC) is a robust mouse genetics resource comprised of a panel of recombinant inbred strains, which model the complexity of the human genome and provide a system within which to understand diseases driven by complex allelic variation. Approach & Results: We infected a panel of CC strains with Norway rat hepacivirus and identified several that failed to clear the virus after 4 weeks. Strains displayed an array of virologic phenotypes ranging from delayed clearance (CC046) to chronicity (CC071, CC080) with viremia for at least 10 months. Body weight loss, hepatocyte infection frequency, viral evolution, T-cell recruitment to the liver, liver inflammation, and the capacity to develop liver fibrosis varied among infected CC strains. Conclusions: These models recapitulate many aspects of HCV infection in humans and demonstrate that host genetic variation affects a multitude of viruses and ho
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet
-
Mashup Score: 1
t and achieved promising therapeutic outcomes by activating viral sensors and interferon-stimulated genes (ISGs) suppressed by HBV. However, the longitudinal landscape of immune cells of CHB patients and the effect of IFN-α on the immune system are not fully understood. Approach and Results: Here, we applied single-cell RNA sequencing (scRNA-seq) to delineate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-α therapy. Notably, we identified three CHB-specific cell subsets, pro-inflammatory (Pro-infla) CD14+ monocytes, Pro-infla CD16+ monocytes and IFNG+ CX3CR1− NK cells, which highly expressed proinflammatory genes and positively correlated with HBsAg. Furthermore, PegIFN-α treatment attenuated percentages of hyperactivated monocytes, increased ratios of long-lived naive/memory T cells and enhanced effector T cell cytotoxicity. Finally, PegIFN-α treatment switched the transcriptional profiles of entire immune cells from TNF-driven to IFN-α
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet
-
Mashup Score: 1LIM domain only 7 negatively controls nonalcoholic... : Hepatology - 4 month(s) ago
al the key regulators of NASH in patients with hyperlipidemia and to explore its role and underlying mechanisms. Approach and Results: To identify the predominant suppressors of NASH in the setting of hyperlipidemia, we collected liver biopsy samples from patients with hyperlipidemia, with or without NASH, and performed RNA-sequencing analysis. Notably, decreased Lineage specific Interacting Motif domain only 7 (LMO7) expression robustly correlated with the occurrence and severity of NASH. Although overexpression of LMO7 effectively blocked hepatic lipid accumulation and inflammation, LMO7 deficiency in hepatocytes greatly exacerbated diet–induced NASH progression. Mechanistically, lysine 48 (K48)-linked ubiquitin-mediated proteasomal degradation of tripartite motif-containing 47 (TRIM47) and subsequent inactivation of the c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK) cascade are required for the protective function of LMO7 in NASH. Conclusions: These findin
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet
-
Mashup Score: 1LIM domain only 7 negatively controls nonalcoholic... : Hepatology - 4 month(s) ago
al the key regulators of NASH in patients with hyperlipidemia and to explore its role and underlying mechanisms. Approach and Results: To identify the predominant suppressors of NASH in the setting of hyperlipidemia, we collected liver biopsy samples from patients with hyperlipidemia, with or without NASH, and performed RNA-sequencing analysis. Notably, decreased Lineage specific Interacting Motif domain only 7 (LMO7) expression robustly correlated with the occurrence and severity of NASH. Although overexpression of LMO7 effectively blocked hepatic lipid accumulation and inflammation, LMO7 deficiency in hepatocytes greatly exacerbated diet–induced NASH progression. Mechanistically, lysine 48 (K48)-linked ubiquitin-mediated proteasomal degradation of tripartite motif-containing 47 (TRIM47) and subsequent inactivation of the c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK) cascade are required for the protective function of LMO7 in NASH. Conclusions: These findin
Source: journals.lww.comCategories: General Medicine News, GastroenterologyTweet
Video of the Week: Emerging Medical Therapies for ALD and NAFLD Mary E. Rinella, MD, FACG ▶️ https://t.co/vs0FyrwV2U #LiverTwitter https://t.co/ljQe5OafoM