England’s first Rare Diseases Action Plan, published on Feb 28 to mark Rare Disease Day 2022, was met with a mixture of hope and apprehension. Hope that the many people who suffer from individual rare diseases will benefit from faster diagnosis and increased support, but apprehension that much of what is promised will be a struggle to deliver given the strained resources of the National Health…

Humoral responses following vaccination are impaired by specific immunosuppressants. After standard vaccination regimens, patients with immune-mediated inflammatory disorders taking most immunosuppressants show similar seroconversion to controls, although antibody titres might be moderately reduced. As neutralisation capacity and recall responses are also preserved in these patients, this is not…

The future of global health care is at risk. The pandemic, along with overwhelming workloads and record waiting lists, has exacerbated existing barriers to ensuring the wellbeing of health-care workers, leading to fatigue, stress, and poor mental health. As a result, health-care workers are leaving their jobs in droves, citing exhaustion and burnout. What will it take to avert further crisis?