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Mashup Score: 6Development of a “Geo-Tagged” tumor sample registry: intra-operative linkage of sample location to imaging - 5 month(s) ago
Journal of Neuro-Oncology – There is a growing body of literature documenting glioma heterogeneity in terms of radiographic, histologic, molecular, and genetic characteristics. Incomplete spatial…
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 8
Purpose To date, immunotherapeutic approaches in glioblastoma (GBM) have had limited clinical efficacy as compared to other solid tumors. Here we explore autologous cell treatments that have the potential to circumvent treatment resistance to immunotherapy for GBM. Methods We performed literature review and assessed clinical outcomes in phase 1 safety trials as well as phase 2 and 3…
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet-
Andrews et al. designed a rigorous double-blinded add-on placebo-controlled trial involving their implantable biologic drug device for glioblastoma-targeted immunotherapy. #JNO @JeffersonUniv Read more: https://t.co/P4i6d8Q9L9 https://t.co/WrlEDNTyeQ
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Mashup Score: 0Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy - 6 month(s) ago
Stem Cell Reviews and Reports – Tumorigenic Cancer Stem Cells (CSCs), often called tumor-initiating cells (TICs), represent a unique subset of cells within the tumor milieu. They stand apart from…
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet-
Borlongan et al. depict the key characteristics of Cancer Stem Cells and their interactions within the tumor microenvironment. @CNU_Med #JNO Read more about the study here: https://t.co/fNdGA1R695 https://t.co/hj4QhU1O8W
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Mashup Score: 5Long-term clinical outcomes of stereotactic radiotherapy for bilateral vestibular schwannomas in neurofibromatosis type 2 patients - 6 month(s) ago
Journal of Neuro-Oncology – The evidence for treating patients with neurofibromatosis 2-related vestibular schwannoma (VS-NF2) using hypofractionated stereotactic radiation therapy (HSRT) is…
Source: link.springer.comCategories: General Medicine News, Onc News and JournalsTweet-
Puataweepong et. al show that robotic hypofractionated stereotactic radiation therapy demonstrated significant long term tumor control with a low non-auditory complication rate in patients with neurofibromatosis 2-related vestibular schwannoma. #JNO https://t.co/FFQvp1qLJB https://t.co/AwKpqVrQ9l
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Mashup Score: 0Pachymeningeal disease: a systematic review and metanalysis - 7 month(s) ago
Journal of Neuro-Oncology – Pachymeningeal disease (PMD) is a newly recognized pattern of brain metastasis (BrM) failure that specifically occurs following surgery with adjuvant stereotactic…
Source: link.springer.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Gutierrez-Valencia et al uncover Pachymeningeal Disease (PMD) as a complication following Stereotactic Radiosurgery. PMD has a better prognosis than Leptomeningeal Disease (LMD). Early recognition is crucial. #BTSM #JNO #neurooncology #braintumor https://t.co/v3HAX7qTOm https://t.co/yaiTW4WIfr
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Mashup Score: 6Residual diffusion-weighted imaging hyperintense signal in primary central nervous system lymphoma can predict early recurrence - 7 month(s) ago
Journal of Neuro-Oncology – The treatment response of primary central nervous system lymphomas (PCNSLs) is mainly evaluated using postcontrast T1-weighted imaging (T1WI). Because poorly enhanced…
Source: link.springer.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Onishi et al assessed DWI's importance in predicting PCNSL recurrence post-treatment. 📊 Patients with residual DWI signal had shorter PFS (14.0 vs. 85.1 months). 💡 DWI complements T1WI for better response evaluation #JNO #neurosurgery https://t.co/b1HANa9Jp3 https://t.co/TtgtEEUBOc
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Mashup Score: 1Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis - 8 month(s) ago
Journal of Neuro-Oncology – Resection of high-grade gliomas has been considerably improved by 5-aminolevulinic acid (5-ALA). However, not all neurobiological properties of 5-ALA are fully…
Source: link.springer.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Immune infiltration patterns of different levels of 5-ALA fluorescence are not defined. Lang et al. add to the current knowledge of 5-ALA biology by assessing correlation of 5-ALA signatures and immune markers histologically and digitally. #BTSM #JNO https://t.co/VX0Q1OABOg https://t.co/adiKQo6fME
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Mashup Score: 11A review on genetic alterations in CNS metastases related to breast cancer treatment. Is there a role for liquid biopsies in CSF? - 9 month(s) ago
Journal of Neuro-Oncology – Acquired mutations or altered gene expression patterns in brain metastases (BM) and/or leptomeningeal metastases (LM) of breast cancer may play a role in…
Source: link.springer.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Is there a role for liquid biopsies in CSF in treating CNS metastases from breast cancer? Check out this recent study in #JNO to learn about how genetic alterations can be identified in CSF samples to guide targetable treatment for these patients. https://t.co/KUp8MwTORu https://t.co/GjNUtsSt8P
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Mashup Score: 2Belzutifan in adults with VHL-associated central nervous system hemangioblastoma: a single-center experience - Journal of Neuro-Oncology - 9 month(s) ago
Purpose Belzutifan is a selective inhibitor of hypoxia-inducible factor 2 alpha (HIF-2a) that has emerged as a targeted therapy option for Von Hippel–Lindau (VHL) syndrome-associated tumors with recent FDA approval. There is limited real-world evidence regarding safety and efficacy in CNS hemangioblastoma. Our objective was to report on our clinical experience with belzutifan in adult patients…
Source: SpringerLinkCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Belzutifan is a newly FDA-approved HIF-2a inhibitor for treatment of VHL-associated tumors, including CNS hemangioblastomas. @MayoClinicNeuro reviewed their experience with this drug. #BTSM #JNO https://t.co/T2jQSZlM5x https://t.co/kAjqcszCOx
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Mashup Score: 0Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors - Journal of Neuro-Oncology - 11 month(s) ago
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (≥ 36 months, Long term survivors, LTS). Methods…
Source: SpringerLinkCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors. #BTSM #JNO @NSTumorSection https://t.co/eNZ4KwMLEx https://t.co/eRZTiUiTel
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Lynes et al. describe a techinque for "geo-tagging" or intraoperative linkage of each tumor sample to its location via neuronavigation @MedStarGUH #JNO Read more: https://t.co/YelOPwGPcj https://t.co/0OnTmygU0N