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Mashup Score: 0Choice Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders - 8 hour(s) ago
Fetal alcohol spectrum disorders (FASDs) are characterized by a range of physical, cognitive, and behavioral impairments. Determining how temporally specific alcohol exposure (AE) affects neural circuits is crucial to understanding the FASD phenotype. Third trimester AE can be modeled in rats by administering alcohol during the first two postnatal weeks, which damages the medial prefrontal cortex (mPFC) and hippocampus (HPC), structures whose functional interactions are required for working memory and executive function. Therefore, we hypothesized that AE during this period would impair working memory, disrupt choice behaviors, and alter mPFC-HPC oscillatory synchrony. To test this hypothesis, we recorded local field potentials from the mPFC and dorsal HPC as male and female AE and sham intubated (SI) rats performed a spatial working memory task in adulthood and implemented algorithms to detect vicarious trial and errors (VTEs), behaviors associated with deliberative decision-making. W
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 4Neural Transformation from Retinotopic to Background-Centric Coordinates in the Macaque Precuneus - 4 day(s) ago
Visual information is initially represented in retinotopic coordinates and later in craniotopic coordinates. Psychophysical evidence suggests that visual information is further represented in more general coordinates related to the external world; however, the neural basis of nonegocentric coordinates remains elusive. This study investigates the automatic transformation from egocentric to nonegocentric coordinates in the macaque precuneus (two males, one female), identified by a functional imaging study as a key area for nonegocentric representation. We found that 6.2% of neurons in the precuneus have receptive fields (RFs) anchored to the background rather than to the retina or the head, while 16% had traditional retinotopic RFs. Notably, these two types were not exclusive: many background-centric neurons initially encode a stimulus’ position in retinotopic coordinates (up to ∼90 ms from the stimulus onset) but later shift to background coordinates, peaking at ∼150 ms. Regarding retin
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 2
Despite significant strides in gender equity, the Nobel Prizes in STEM fields continue to exhibit glaring disparities in the recognition of women’s contributions to science. Thirty years ago, only 3% of Nobel laureates in science were women; today, that number has increased marginally to 4%, raising the critical question: Why “still” so few? This opinion piece examines systemic inequities and structural barriers that hinder the equitable acknowledgment of women’s and underrepresented groups’ contributions to science. Data reveal that while women now comprise a significant proportion of degree recipients and workforce entrants in fields such as biomedical research and chemistry, their representation among Nobel laureates remains disproportionately low. Furthermore, racial inequities exacerbate the lack of diversity, with no Black individuals receiving a Nobel Prize in STEM fields to date. The article advocates for transformative changes in academic and research ecosystems to dismantle t
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 4Characterizing olfactory brain responses in young infants - 7 day(s) ago
Odor perception plays a critical role in early human development, but the underlying neural mechanisms are not fully understood. To investigate these, we presented appetitive and aversive odors to infants of both sexes at one month of age while recording functional magnetic resonance imaging (fMRI) and nasal airflow data. Infants slept during odor presentation to allow MRI scanning. We found that odors evoke robust fMRI activity in bilateral olfactory cortex and thalamus, and that fMRI response magnitudes in olfactory cortex differ across odors. However, in contrast with prior work in adults, we did not find compelling evidence that odor stimuli evoke discriminable fMRI activity patterns in olfactory cortex or thalamus using two different multivariate pattern analysis techniques. Finally, the average inhale airflow rate was higher for appetitive odors than aversive odors, which tentatively suggests that infants could modulate their respiration to reflect odor valence. Overall, these re
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 6This Week in The Journal - 12 day(s) ago
Mapping the Early Developmental Timeline for Auditory Neural Coding Bahar Saadatmehr, Mohammadreza Edalati, Fabrice Wallois, Ghida Ghostine, Guy Kongolo et al. (see article e0398242024) An important stage of mammalian neurodevelopment is the onset of sound and auditory rhythm processing by the brain. The human brain responds to sounds as early as the beginning of the third trimester of pregnancy. To extend this finding in a new study, Saadatmehr et al. explored the development by the end of pregnancy. They used EEG to …
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Mashup Score: 3Anterior Olfactory Cortices Differentially Transform Bottom-Up Odor Signals to Produce Inverse Top-Down Outputs - 13 day(s) ago
Odor information arrives first in the main olfactory bulb and is then broadcasted to the olfactory cortices and striatum. Downstream regions have unique cellular and connectivity architectures that may generate different coding patterns to the same odors. To reveal region-specific response features, tuning and decoding of single-unit populations, we recorded responses to the same odors under the same conditions across regions, namely, the main olfactory bulb (MOB), the anterior olfactory nucleus (AON), the anterior piriform cortex (aPC), and the olfactory tubercle of the ventral striatum (OT), of awake male mice. We focused on chemically closely related aldehydes that still create distinct percepts. The MOB had the highest decoding accuracy for aldehydes and was the only region encoding chemical similarity. The MOB had the highest fraction of inhibited responses and narrowly tuned odor-excited responses in terms of timing and odor selectivity. Downstream, the interconnected AON and aPC
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Mashup Score: 20Sequential Activation of Lateral Hypothalamic Neuronal Populations during Feeding and Their Assembly by Gamma Oscillations - 13 day(s) ago
Neural circuits supporting innate behaviors, such as feeding, exploration, and social interaction, intermingle in the lateral hypothalamus (LH). Although previous studies have shown that individual LH neurons change their firing relative to the baseline during one or more behaviors, the firing rate dynamics of LH populations within behavioral episodes and the coordination of behavior-related LH populations remain largely unknown. Here, using unsupervised graph-based clustering of LH neurons firing rate dynamics in freely behaving male mice, we identified distinct populations of cells whose activity corresponds to feeding, specific times during feeding bouts, or other innate behaviors—social interaction and novel object exploration. Feeding-related cells fired together with a higher probability during slow and fast gamma oscillations (30–60 and 60–90 Hz) than during nonrhythmic epochs. In contrast, the cofiring of neurons signaling other behaviors than feeding was overall similar betwee
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#JNeurosci: @Mahsaaltafi et al. identified distinct groups of neurons in the lateral hypothalamus of mice that are activated in sequences during eating or consistently active during food intake, social interaction, or exploration of new objects. @UniFAU https://t.co/45peMeBpHm https://t.co/PJHMERGoiI
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Mashup Score: 18Decision-Making with Predictions of Others’ Likely and Unlikely Choices in the Human Brain - 22 day(s) ago
For better decisions in social interactions, humans often must understand the thinking of others and predict their actions. Since such predictions are uncertain, multiple predictions may be necessary for better decision-making. However, the neural processes and computations underlying such social decision-making remain unclear. We investigated this issue by developing a behavioral paradigm and performing functional magnetic resonance imaging and computational modeling. In our task, female and male participants were required to predict others’ choices in order to make their own value-based decisions, as the outcome depended on others’ choices. Results showed, to make choices, the participants mostly relied on a value difference (primary) generated from the case where others would make a likely choice, but sometimes they additionally used another value difference (secondary) from the opposite case where others make an unlikely choice. We found that the activations in the posterior cingul
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 3μ-Opioid Receptor Modulation of the Glutamatergic/GABAergic Midbrain Inputs to the Mouse Dorsal Hippocampus - 25 day(s) ago
We used virus-mediated anterograde and retrograde tracing, optogenetic modulation, immunostaining, in situ hybridization, and patch-clamp recordings in acute brain slices to study the release mechanism and μ-opioid modulation of the dual glutamatergic/GABAergic inputs from the ventral tegmental area and supramammillary nucleus to the granule cells of the dorsal hippocampus of male and female mice. In keeping with previous reports showing that the two transmitters are released by separate active zones within the same terminals, we found that the short-term plasticity and pharmacological modulation of the glutamatergic and GABAergic currents are indistinguishable. We further found that glutamate and GABA release at these synapses are both virtually completely mediated by N- and P/Q-type calcium channels. We then investigated μ-opioid modulation of these synapses and found that activation of μ-opioid receptors (MORs) strongly inhibits the glutamate and GABA release, mostly through inhibit
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 0This Week in The Journal - 26 day(s) ago
Uncovering the Functions of Disease-Associated Genomic Variants Jessica Dunn, Cedric Moore, Namshik Kim, Tianshun Gao, Zhiqiang Cheng et al. (see article e1800242024) Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) associated with complex diseases, such as Alzheimer’s disease (AD). But scientists have not yet uncovered the functional contributions of these SNPs to their respective diseases. In this issue, Dunn and colleagues developed a program to help shed …
Source: www.jneurosci.orgCategories: General Medicine News, NeurologyTweet
New in #JNeurosci: @Hailey_lr, @Suhyeong4, @_JohnStout_, Klintsova, and @amydief identified a brain circuit in rodents that is disrupted by alcohol exposure during prenatal development and contributes to poor decision-making. @UDelaware https://t.co/SRtTluVSpe https://t.co/ayVpnpaIub