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Mashup Score: 1
Key Points. BcfA-adjuvanted vaccines reduce MA10 viral load at 3 mo postbooster.Respiratory damage is prevented by BcfA-adjuvanted vaccines.Neutralizing Abs and
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Mashup Score: 0
Key Points. IFN-γ contributes to control of acute and chronic blood-stage Pcc malaria.CD4 T cell IFN-γ contributes to control of chronic Pcc blood-stage malaria
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Mashup Score: 2
Key Points. Quality and stability of fluorescent ligand tetramers can vary from batch to batch.Ligand tetramers can be sensitively assessed using Abs bound to b
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Mashup Score: 11Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity - 1 year(s) ago
Key Points. DC2 limit initial metastatic burden in the lung.In response to tumor-derived nucleic acids, DC2 produce host-required IL-12p40.Local DC2 and NK cell
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Mashup Score: 0Chlamydia pneumoniae Lung Infection in Mice Induces Fatty Acid–Binding Protein 4–Dependent White Adipose Tissue Pathology - 1 year(s) ago
Key Points. C. pneumoniae lung infection causes lipolysis in WAT in a FABP4-dependent manner.Infection-induced FABP4 secretion augments ER stress and promotes M
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Mashup Score: 4Commensal Bacteria and the Lung Environment Are Responsible for Th2-Mediated Memory Yielding Natural IgE in MyD88-Deficient Mice - 1 year(s) ago
Key Points. Memory B cells continuously produce serum natural IgE in MyD88−/− mice.Natural IgE is induced by the bacteria accumulated in the lung of MyD88−/− mi
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Mashup Score: 1First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα - 1 year(s) ago
Key Points. OSE-127 infusion shows lack of significant lymphopenia in healthy volunteers.OSE-127 infusion demonstrates lack of serious adverse events in healthy
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Mashup Score: 0Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection - 1 year(s) ago
Key Points. Cytokine-producing, monocyte-derived macrophages are readily infected by M-CoV.Type I IFNs curtail viral replication and sustain proinflammatory mac
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Mashup Score: 0Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein - 1 year(s) ago
Key Points. lncRNA U90926 is upregulated in TLR-stimulated macrophages.U90926 contains a translated ORF that encodes a secreted protein.U90926 knockout mice are
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Mashup Score: 0Increased Inflammasome Activation Is Associated with Aging and Chronic Myelomonocytic Leukemia Disease Severity - 1 year(s) ago
Key Points. Aging increases IL-1β production upon NLRP3 activation in human monocytes.Pam3CSK4 directly activates the NLRP3 inflammasome in monocytes from older
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#JI_TopRead from @Mohamed95809452 & Purnima Dubey @MicrobiologyOSU | BcfA-adjuvanted prime-pull #SARSCoV2 subunit #vaccine strategy can elicit long-lived local & systemic immune responses | #ReadTheJI #immunology #coronavirus 👉 https://t.co/xMQkSNDUoR https://t.co/HfSwkNOGiw