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Mashup Score: 9
IFNs are comprised of three families of cytokines that confer protection against pathogen infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and adaptive immune regulation has placed them under heavy scrutiny to position them as “friend” or “foe” across pathologies. Genetic lesions in genes involving IFN synthesis and signaling underscore the disparate outcomes…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3The Minority Scientists’ Experience: Challenging and Overcoming Barriers to Enhancing Diversity and Career Advancement - 2 year(s) ago
Minority groups face barriers in accessing quality health care, professional advancement, and representation in immunology research efforts as a result of institutional racism that if unaddressed can perpetuate a lack of diversity. In 2021, the AAI Minority Affairs Committee convened a cross section of academic and industry scientists from underrepresented groups at various stages of their…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 7Altered Offspring Immunity in Maternal Parasitic Infections - 2 year(s) ago
Maternal infection during pregnancy is known to alter the development and function of offspring’s immune system, leading to inappropriate immune responses to common childhood infections and immunizations. Although this is an expanding field, maternal parasitic infections remain understudied. Millions of women of reproductive age are currently at risk for parasitic infection, whereas many…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 6Immunological Diversity Is a Cornerstone of Organismal Defense and Allorecognition across Metazoa - 2 year(s) ago
The ongoing arms race between hosts and microbes has fueled the evolution of novel strategies for diversifying the molecules involved in immune responses. Characterization of immune systems from an ever-broadening phylogenetic range of organisms reveals that there are many mechanisms by which this diversity can be generated and maintained. Diversification strategies operate at the level of…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 5Features of B Cell Responses Relevant to Allergic Disease - 2 year(s) ago
This Brief Review delves into B cell responses in the context of allergy. The primary contribution of B cells to allergy is the production of IgE, the Ab isotype that triggers immediate hypersensitivity reactions through the release of mediators from mast cells and basophils. B cells may also have protective roles in allergy, such as through the production of IgG or as regulatory B cells. In this…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 6
Inflammasomes are important in human health and disease, whereby they control the secretion of IL-1β and IL-18, two potent proinflammatory cytokines that play a key role in inflammatory responses to pathogens and danger signals. Several inflammasomes have been discovered over the past two decades. NLRP3 inflammasome is the best characterized and can be activated by a wide variety of inducers. It…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3The Importance of Diversity in Immunology - 2 year(s) ago
Life on our planet relies on a global ecosystem composed of diverse, interdependent forces that must strike a harmonious balance. On an organismal level, immunologists have a deep appreciation for balanced integration of diversity, with disease resistance and our overall health depending on a
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 4The Importance of Diversity in Immunology - 2 year(s) ago
Life on our planet relies on a global ecosystem composed of diverse, interdependent forces that must strike a harmonious balance. On an organismal level, immunologists have a deep appreciation for balanced integration of diversity, with disease resistance and our overall health depending on a
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 16The Journal of Immunology: 208 (2) - 2 year(s) ago
January 15, 2022; Volume 208,Issue 2 TOP READS Top ReadsIFN-γ Promotes Cell Surface IL-15 See article p. 338DNA Methylation Promotes…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 19The Journal of Immunology: 208 (2) - 2 year(s) ago
January 15, 2022; Volume 208,Issue 2 TOP READS Top ReadsIFN-γ Promotes Cell Surface IL-15 See article p. 338DNA Methylation Promotes…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
Beyond good and evil: Molecular #mechanisms of type I and III #IFN functions by @adforu & @dowlja11 @OSUWexMed |#BriefReview in #JI_celebratediversity https://t.co/dwlStDiy19 #ReadTheJI #IFNlambda #cytokines https://t.co/A1yucJsRGs