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    ASCO recently published new guidance on systemic therapy for tumor control in well-differentiated metastatic gastrointestinal and pancreatic neuroendocrine tumors in the Journal of Clinical Oncology. A companion Q and A article in the JCO-OP addresses some of the questions that clinicians may face as they implement these recommendations into clinical practice, including the role of somatostatin receptors and observation, definition of terms used within the guideline, considerations related to therapy options for G3 NETs, and future direction in research and treatment. ASCO also plans to address recommendations on the topic of symptom control of GEP-NETs in a forthcoming guideline

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    • ❓ #JCOOP Q&A for @ASCO's new guideline for systemic therapy for tumor control in well-differentiated metastatic gastrointestinal and pancreatic #neuroendocrine tumors. ➡️ https://t.co/upC2tLmwQ6 #NET #pancsm @JaydiDelRivero

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    Over the past decade, tremendous efforts have been made in the development of targeted agents in non–small-cell lung cancer (NSCLC) with nonsquamous histology. Pivotal studies have used next-generation sequencing to select the patient population harboring oncogenic driver alterations that are targetable with targeted therapies. As treatment paradigm rapidly evolves for patients with rare oncogene-driven NSCLC, updated comprehensive overview of diagnostic approach and treatment options is paramount in clinical settings. In this review article, we discuss the epidemiology, molecular testing, and landmark clinical trials addressing the targeted agents for ROS1 rearrangement, METex14 skipping mutation, EGFR exon 20 insertion, KRAS G12C mutation, HER2 mutation, RET fusion, NTRK fusion, and BRAF mutations.

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    • 🔬Over the past decade, tremendous efforts have been made in the development of targeted agents in nonsquamous #NSCLC #lungcancer. This #JCOOP review discusses the epidemiology, testing, & landmark clinical trials for ROS1, EGFR, KRAS, BRAF etc ➡️ https://t.co/qfi4LIDGWx #lcsm https://t.co/gOiqznNu2T

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    AUTHOR’S DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationship s may not relate to the subject matter of this manuscript. For more information about ASCO’s conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/op/authors/author

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    • #JCOOP Editorial: New research for #TesticularCancer should focus on 1) improving cure rates for bad-risk #NSGCT 2) better management of late relapse & transformed teratomas 3) identifying new molecular markers to improve dx & prognostication: https://t.co/JYfLLEyYkU