-
Mashup Score: 6Novel Mechanisms of Postural Hyperventilation in Postural Orthostatic Tachycardia Syndrome: Toward Discovery of Terra Incognita - 6 month(s) ago
Corresponding Author
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet
-
Mashup Score: 0Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress: - 8 month(s) ago
Highlights •HuR, an RNA-binding protein, plays a critical role in organ fibrosis across various pathologies.•A novel conditional tamoxifen-inducible HuR knockout mouse enabled the deletion of HuR f…
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
In #JACCBTS, Dr. Patil et al. demonstrate that myofibroblast-specific deletion of human antigen R (HuR) 📉 cardiac fibrosis & dysfunction + myofibroblast proliferation. Findings suggest potential therapeutic benefits to targeting HuR in cardiac fibrosis. https://t.co/Ij6ctv84ea https://t.co/bs3cZrss37
-
-
Mashup Score: 46Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase: Unraveling the IL-6/MCP-1/STAT3 Axis - 9 month(s) ago
Highlights •MCP-1 and IL-6 blood levels peak at 24 hours in STEMI patients and are associated with an increased risk of MACE.•Blood levels of MCP-1 and IL-6 peak at 3 hours in a mouse model of STEM…
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
In a post-MI mouse model, inhibiting the IL-6/MCP-1/STAT3 axis at reperfusion onset reduces infarct size, highlighting potentially deleterious role of anti-inflammatory macrophages. Read the new #JACCBTS study by Drs. @alexPaccalet, @crola_da et al here: https://t.co/Mgo4HIJbBt https://t.co/bvheUo3lBZ
-
-
Mashup Score: 90Comprehensive RV Hemodynamic Assessment With Pressure-Volume Analysis During Impella Support: Findings From the CHAMP-IMPELLA Study - 11 month(s) ago
∗Division of Cardiology, Columbia University Medical Center, Presbyterian Hospital, 622 West 168th Street, 3rd Floor, Room 347, New York, New York 10087, US A. E-mail: E-mail Address: [email protected] Drs Moses and Uriel contributed equally to this work. Drs Moses and Uriel contributed equally to this work. Percutaneous ventricular assist devices (pVADs) such as the Impella CP (Abiomed) are widely used for the prevention and management of cardiogenic shock caused by left ventricular (LV) dysfunction.
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Findings from @ColumbiaMed's CHAMP-IMPELLA study elucidate the effects of Impella-CP unloading on RV function: improved RV-PA coupling due to decreased afterload while RV systolic function remained unchanged w/ increased P-level (i.e. P2 to P8). https://t.co/wqPsWRlNnV #JACCBTS https://t.co/PasbJeP5eO
-
-
Mashup Score: 83Reducing Abdominal Aortic Aneurysm Progression by Blocking Neutrophil Extracellular Traps Depends on Thrombus Formation: - 11 month(s) ago
Highlights •For AAA, surgical repair remains the only treatment to date, with a lack of drug options for management of aneurysm progression or rupture risk.•NETs are implicated in the pathogenesis …
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Preventing formation of neutrophil extracellular traps holds promise for pharmaceutical management of abdominal aortic aneurysms with a thrombus component. Read the new #JACCBTS study by Dr. Nahla Ibrahim, and colleagues: https://t.co/CJh9hoAJFV https://t.co/HtlQYvMTKn
-
-
Mashup Score: 0Is it Time to Abandon the Use of P-Values in Early Phase Translational Trials: Why (Effect) Size Matters: - 11 month(s) ago
∗Address for correspondence: Dr Douglas L. Mann, Editor-in-Chief, JACC: Basic to Translational Science, American College of Cardiology, Heart House, 2400 N Street Northwest, Washington, DC 20037, USA. E-mail: E-mail Address: [email protected] Ph ase 1 clinical trials are primarily designed to test the safety of new drugs or devices. However, increasingly, phase 1 studies are being used as hypothesis-generating studies to help inform endpoints for larger phase 2 studies. Traditionally, researchers have
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Check out this thoughtful #JACCBTS commentary by EiC @DLMann_MD on the use of P-values in early phase translational trials. https://t.co/yXHoTCpK7S Should we focus on effect size instead? 🤔
-
-
Mashup Score: 64
Highlights • Two-faced polycaprolactone patches were electrospun. The luminal face consisted of aligned fibers designed to align with blood flow, to promote endothelial cell migration and to stop u…
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
A novel adhesive bioresorbable patch to treat aortic dissections was assessed ex vivo and in vivo in rams, with minimal to no inflammation & thrombogenicity up to 90 days. https://t.co/aOwpmzNLAc #JACCBTS @uramonllull @hospitalclinic https://t.co/g0Y2bi6Eqt
-
-
Mashup Score: 28
Corresponding Author
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Ticagrelor Antibiotic Effect: Ready for Exploring Clinical Implementation? Read the editorial by Drs. Helena Martinez-Selles & @MMSelles on the #JACCBTS study about a novel role for ticagrelor in infective endocarditis: https://t.co/nvzX4hGGPd
-
-
Mashup Score: 20Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology: - 1 year(s) ago
Highlights • Circadian disruption secondary to behaviors (eg, shift work, night eating, etc) and single nucleotide polymorphisms (within circadian clock genes) increases risk for cardiometabolic an…
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Genetic disruption of the cardiomyocyte circadian clock reveals that the transcriptional repressor E4BP4 is a regulator of cardiac metabolism & electrophysiology. Read about this novel role for E4BP4 in the #JACCBTS study by Drs. Mia, Young & colleagues: https://t.co/Hq6H0Nh3AN https://t.co/IiSYxfodN0
-
-
Mashup Score: 5Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post–Myocardial Infarction: - 1 year(s) ago
Highlights • Vagal nerve stimulation has emerged as a promising therapeutic approach to combat the observed withdrawal of parasympathetic tone and to counteract the reflex-mediated sympathoexcitati…
Source: www.jacc.orgCategories: Latest Headlines, Partners & KOLsTweet-
Vagal nerve stimulation reduces ventricular arrhythmias & mitigates adverse neural-cardiac remodeling post-myocardial infarction in a pig model. Read about this novel treatment in the new #JACCBTS study by Drs. Hadaya, Ardell & colleagues: https://t.co/p4WgzidjuP #cvMI #EPeeps https://t.co/wl75HCqZ2e
-
In this #JACCBTS editorial, Drs. @Cardiaficionado & @StavrosStavrak1 discuss recent findings suggesting a role for reduced stroke volume and brain perfusion in postural orthostatic tachycardia syndrome. https://t.co/J3SDxu21XE