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Mashup Score: 90Comprehensive RV Hemodynamic Assessment With Pressure-Volume Analysis During Impella Support: Findings From the CHAMP-IMPELLA Study - 1 month(s) ago
∗Division of Cardiology, Columbia University Medical Center, Presbyterian Hospital, 622 West 168th Street, 3rd Floor, Room 347, New York, New York 10087, US A. E-mail: E-mail Address: [email protected] Drs Moses and Uriel contributed equally to this work. Drs Moses and Uriel contributed equally to this work. Percutaneous ventricular assist devices (pVADs) such as the Impella CP (Abiomed) are widely used for the prevention and management of cardiogenic shock caused by left ventricular (LV) dysfunction.
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Mashup Score: 83Reducing Abdominal Aortic Aneurysm Progression by Blocking Neutrophil Extracellular Traps Depends on Thrombus Formation: - 1 month(s) ago
Highlights •For AAA, surgical repair remains the only treatment to date, with a lack of drug options for management of aneurysm progression or rupture risk.•NETs are implicated in the pathogenesis …
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Preventing formation of neutrophil extracellular traps holds promise for pharmaceutical management of abdominal aortic aneurysms with a thrombus component. Read the new #JACCBTS study by Dr. Nahla Ibrahim, and colleagues: https://t.co/CJh9hoAJFV https://t.co/HtlQYvMTKn
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Mashup Score: 0Is it Time to Abandon the Use of P-Values in Early Phase Translational Trials: Why (Effect) Size Matters: - 1 month(s) ago
∗Address for correspondence: Dr Douglas L. Mann, Editor-in-Chief, JACC: Basic to Translational Science, American College of Cardiology, Heart House, 2400 N Street Northwest, Washington, DC 20037, USA. E-mail: E-mail Address: [email protected] Ph ase 1 clinical trials are primarily designed to test the safety of new drugs or devices. However, increasingly, phase 1 studies are being used as hypothesis-generating studies to help inform endpoints for larger phase 2 studies. Traditionally, researchers have
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Check out this thoughtful #JACCBTS commentary by EiC @DLMann_MD on the use of P-values in early phase translational trials. https://t.co/yXHoTCpK7S Should we focus on effect size instead? 🤔
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Mashup Score: 64
Highlights • Two-faced polycaprolactone patches were electrospun. The luminal face consisted of aligned fibers designed to align with blood flow, to promote endothelial cell migration and to stop u…
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A novel adhesive bioresorbable patch to treat aortic dissections was assessed ex vivo and in vivo in rams, with minimal to no inflammation & thrombogenicity up to 90 days. https://t.co/aOwpmzNLAc #JACCBTS @uramonllull @hospitalclinic https://t.co/g0Y2bi6Eqt
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Mashup Score: 28
Corresponding Author
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Ticagrelor Antibiotic Effect: Ready for Exploring Clinical Implementation? Read the editorial by Drs. Helena Martinez-Selles & @MMSelles on the #JACCBTS study about a novel role for ticagrelor in infective endocarditis: https://t.co/nvzX4hGGPd
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Mashup Score: 20Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology: - 6 month(s) ago
Highlights • Circadian disruption secondary to behaviors (eg, shift work, night eating, etc) and single nucleotide polymorphisms (within circadian clock genes) increases risk for cardiometabolic an…
Source: www.jacc.orgCategories: General Medicine News, Partners & KOLsTweet-
Genetic disruption of the cardiomyocyte circadian clock reveals that the transcriptional repressor E4BP4 is a regulator of cardiac metabolism & electrophysiology. Read about this novel role for E4BP4 in the #JACCBTS study by Drs. Mia, Young & colleagues: https://t.co/Hq6H0Nh3AN https://t.co/IiSYxfodN0
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Mashup Score: 5Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post–Myocardial Infarction: - 7 month(s) ago
Highlights • Vagal nerve stimulation has emerged as a promising therapeutic approach to combat the observed withdrawal of parasympathetic tone and to counteract the reflex-mediated sympathoexcitati…
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Vagal nerve stimulation reduces ventricular arrhythmias & mitigates adverse neural-cardiac remodeling post-myocardial infarction in a pig model. Read about this novel treatment in the new #JACCBTS study by Drs. Hadaya, Ardell & colleagues: https://t.co/p4WgzidjuP #cvMI #EPeeps https://t.co/wl75HCqZ2e
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Mashup Score: 9Empagliflozin Suppresses the Differentiation/Maturation of Human Epicardial Preadipocytes and Improves Paracrine Secretome Profile: - 7 month(s) ago
Highlights • SGLT2 is primarily expressed in human preadipocytes in the epicardial adipose tissue. • The expression levels of SGLT2 diminish as the preadipocytes are differentiated to mature adipoc…
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This #JACCBTS study demonstrated that the secretome profile modification of human EAT by #SGLT2i suppresses oxidative stress in human cardiomyocytes. Intervention in the quantity & quality of EAT may be a new therapeutic target for preventing #CVD. https://t.co/boCt3TdcXz #cvPrev https://t.co/TgL1oCtarT
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Mashup Score: 7
Highlights • Inflammation is intricately intertwined with coagulation and plays a critical role in venous thrombogenesis. • NLRP3 inflammasome activation, pyroptosis, and IL-1 are emerging contribu…
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#JACCBTS state-of-the-art review provides an overview of preclinical and clinical evidence supporting IL-1 and the NLRP3 inflammasome as potential therapeutic targets in #VTE: https://t.co/8NF6dleEtR #CardioTwitter @NicolaPotereMD @YogenKanthi @MarcCarrier1 @MarcelloDiNisio https://t.co/i4vIL6cB1i
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Mashup Score: 2
Corresponding Author
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#PCSK9i quenching the flames of pyroptosis: more than just lipid lowering in chronic limb-threatening ischemia (CLTI)? Read the editorial by Drs. Okazaki & @NaomiHamburg on the new #JACCBTS study about a novel role for #PCSK9 in CLTI pathophysiology: https://t.co/oxnZhnInzE https://t.co/OgWXlsNhRW
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Findings from @ColumbiaMed's CHAMP-IMPELLA study elucidate the effects of Impella-CP unloading on RV function: improved RV-PA coupling due to decreased afterload while RV systolic function remained unchanged w/ increased P-level (i.e. P2 to P8). https://t.co/wqPsWRlNnV #JACCBTS https://t.co/PasbJeP5eO