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Mashup Score: 0
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Source: www.ishlt.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
We discovered a threshold for reduced BALF CCSP to discriminate future CLAD risk; supporting the utility of BALF CCSP as a tool for early posttransplant risk stratification. Additionally, our finding that low CCSP associates with future CLAD underscores a role for club cell injury in CLAD pathobiolo …
Source: pubmed.ncbi.nlm.nih.govCategories: Cardiology News and Journals, Latest HeadlinesTweet-
1⃣ @NCortesMD of @TexasChildrens presents a study by Jamie Todd, et al, from @TheJHLT on if club cell secretory protein (#CSSP) levels in #BALF can serve as a #biomarker for #CLAD. 🫁▶️https://t.co/jl6uGUsE0j #ISHLT #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/LfkHIYcge6
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Mashup Score: 0Clinical relevance of cell-free DNA quantification and qualification during the first month after lung transplantation - 7 month(s) ago
BackgroundMany studies have reported the relevance of donor-derived cfDNA (dd-cfDNA) after lung transplantation (LTx) to diagnose and monitor acute rejection (AR) or chronic rejection or infection (INF). However, the analysis of cfDNA fragment size has not been studied. The aim of this study was to determine the clinical relevance of dd-cfDNA and cfDNA size profiles in events (AR and INF) during the first month after LTx.MethodsThis prospective, single-center study includes 62 LTx recipients at the Marseille Nord Hospital, France. Total cfDNA quantification was performed by fluorimetry and digital PCR, dd-cfDNA by NGS (AlloSeq cfDNA-CareDX®), and the size profile by BIABooster (Adelis®). A bronchoalveolar lavage and transbronchial biopsies at D30 established the following groups: not-injured and injured graft (AR, INF, or AR+INF).ResultsQuantification of total cfDNA was not correlated with the patient’s status at D30. The percentage of dd-cfDNA was significantly higher for injured graf
Source: www.frontiersin.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet-
2⃣ Federica Pezzuto presents a study from @FrontImmunol by Pascal Pedini et al on the clinical relevance of #ddcfDNA and #cfDNA in evaluating patients after #LungTx. 🫁▶️ https://t.co/cacZ2mNwWp #ISHLT #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/8tHGSOorNC
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Mashup Score: 0
Clinical Transplantation is an international transplantation journal publishing the latest research surrounding organ and tissue transplant surgery.
Source: onlinelibrary.wiley.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
3⃣ Alessia Giarraputo presents a study in @CliniTransplant from Erick Romero et al on if unsupervised #GEP can evaluate endomyocardial biopsy using only sequencing data, without relying on #histology. 🫀▶️ https://t.co/lTAhY7MYDR #ISHLT #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/6nuZkFc3Fh
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Mashup Score: 0Comparison of two donor‐derived cell‐free DNA tests and a blood gene‐expression profile test in heart transplantation - 7 month(s) ago
Clinical Transplantation is an international transplantation journal publishing the latest research surrounding organ and tissue transplant surgery.
Source: onlinelibrary.wiley.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
4⃣ Maja Nackenhorst @MenUni_Wien presents a study by Nicholas Rodgers et al from @CliniTransplant comparing testing accuracy of 2 #ddcfDNA/#GEP products in evaluating #HeartTx recipients for acute rejection. 🫀▶️ https://t.co/E7vh0h0lNf #ISHLT #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/0GKhdRb7qA
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Mashup Score: 0Prediction of heart transplant rejection from routine pathology slides with self-supervised deep learning - 7 month(s) ago
AbstractAims. One of the most important complications of heart transplantation is organ rejection, which is diagnosed on endomyocardial biopsies by pathologists
Source: academic.oup.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
5⃣ Alexander Wein of @wusm_pathology presents a study from @tpseraphin in @ESC_Journals examining how computer-based #deeplearning systems can assist in diagnosing or predicting #HeartTx #rejection. 🫀▶️ https://t.co/89pieXh4i4 #ISHLT #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/nksDduW4sA
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Mashup Score: 0Tocilizumab for antibody-mediated rejection treatment in lung transplantation - PubMed - 8 month(s) ago
Tocilizumab (TCZ), an IL-6 inhibitor, has shown promise in the treatment of donor-specific antibodies (DSA) and chronic antibody-mediated rejection (AMR) in renal transplant recipients. However, its use in lung transplantation has not been described. This retrospective case-control study compared AM …
Source: pubmed.ncbi.nlm.nih.govCategories: Cardiology News and Journals, Latest HeadlinesTweet-
1⃣ @KrystaWalter12 presents a study from June @TheJHLT on #Tocilizumab for #AMR Treatment in #LungTx, by first author S.E. January. 🫁▶️https://t.co/5ARZOgHRDC #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/vgnKINLS5H
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Mashup Score: 1First use of imlifidase desensitization in a highly sensitized lung transplant candidate: a case report - PubMed - 8 month(s) ago
Lung transplant candidates who are highly sensitized against human leucocyte antigen present an ongoing challenge with regards to finding immunologically acceptable donors. Desensitization strategies aimed at reducing preformed donor-specific antibodies have a number of limitations. Imlifidase, an I …
Source: pubmed.ncbi.nlm.nih.govCategories: Cardiology News and Journals, Latest HeadlinesTweet-
2⃣ Ashley Postell @MayoClinic shares a case report on first use of #Imlifidase desensitization in a highly #sensitized #LungTx Candidate, by first author @drAntoineRoux. 🫁▶️https://t.co/nTmgTckhIS #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/RWQ0EaupeI
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Mashup Score: 0Three year post heart transplant outcomes of desensitized durable mechanical circulatory support patients - PubMed - 8 month(s) ago
DST for MCS patients showed significant PRA reduction, resulting in an expansion of the donor pool. The post-transplant outcome of desensitized MCS patients showed comparable clinical outcomes to non-desensitized control patients in the same study period, revealing the safety and efficacy of DST.
Source: pubmed.ncbi.nlm.nih.govCategories: Cardiology News and Journals, Latest HeadlinesTweet-
3⃣ @PharmDaryl presents 3-year outcomes post #HeartTx of desensitized durable #MCS, from first author JC Youn @CedarsSinai. 🫀▶️https://t.co/dGrOt6WqjI #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/K7y3jbJRYi
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Mashup Score: 1A randomized controlled trial of presatovir for respiratory syncytial virus after lung transplant - PubMed - 8 month(s) ago
Presatovir treatment did not significantly improve change in nasal RSV load, symptoms, or lung function in lung transplant recipients.
Source: pubmed.ncbi.nlm.nih.govCategories: Cardiology News and Journals, Latest HeadlinesTweet-
4⃣ @thecurly_Rx presents a #RCT of #presatovir for #RSV after #LungTx, from first author @GottliebJens. 🫁▶️https://t.co/7IKSgtpxq9 #ISHLTJournalWatch #ISHLTEarlyCareer https://t.co/5m33aJ48NS
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🫀🦠🫁 October #ISHLTJournalWatch is out w/#Pathology #Transplantation topics! Issue edited by Federica Pezzuto, & feat. contributors @NCortesMD, Alessia Giarraputo, Maja Nackenhorst, and Alexander Wein. Thanks to senior editor @avfDO. 🔖 Read now: https://t.co/hXAiaUj3II #ISHLT https://t.co/2nuorZypQO