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Mashup Score: 10Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy - 10 hour(s) ago
Abstract. Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non–small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1Immunotherapy Testing Recommendations Released - 4 day(s) ago
In collaboration with several organizations, the College of American Pathologists (CAP) has released recommendations for testing of immunotherapy biomarkers, including PD-L1 and tumor mutation burden, in patients with non–small cell lung cancer (NSCLC). The guidelines, developed with the International Association for the Study of Lung Cancer, Pulmonary Pathology Society, Association for Molecular Pathology, and LUNGevity Foundation, outline the challenges associated with PD-L1 testing and assessment, including the development of nonuniform companion diagnostic tests (Arch Pathol Lab Med 2024 Apr 16 [Epub ahead of print]). It also explains the rationale for the use of tumor mutation burden and the limitations of these tests for patients with NSCLC. CAP noted that the development of the guidelines was “driven by production of PD-L1 assays and scoring criteria that have evolved with individual therapies. At the same time, for reasons of cost and access, PD-L1 IHC antibodies and assays dev
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 54FDA Approves Toripalimab for Advanced Nasopharyngeal Cancer - 11 day(s) ago
Adding toripalimab (Loqtorzi) to chemo extended survival in people with nasopharyngeal cancer that returned after initial treatment or spread in the body.
Source: www.cancer.govCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 9What to know about TIL therapy, a new treatment for skin cancer - 12 day(s) ago
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Source: health.osu.eduCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 13Novel Mechanism Supports Antitumor Response and T-cell Survival - 14 day(s) ago
A recent Northwestern Medicine study has discovered a previously unknown molecular mechanism that supports antitumor responses and cell survival in cytotoxic immune cells, according to findings published in the Journal of Clinical Investigation.
Source: news.feinberg.northwestern.eduCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1Evaluating relapse-free survival as an endpoint for overall survival in adjuvant immunotherapy trials - 26 day(s) ago
AbstractBackground. Relapse-free survival (RFS) has been considered a primary endpoint to assess the effects of immunotherapy in the adjuvant setting among
Source: academic.oup.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 2
Abstract. Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and interprotein interactions. Targeting PTM of PD-1 in T cells has emerged as a potential strategy to overcome PD-1–mediated immunosuppression in cancer and enhances antitumor immunity. The regulatory signaling pathways that induce PTM of PD-1 can be suppressed with small-molecule inhibitors, and mAbs can directly target PD-1 PTMs. Preliminary outcomes from exploratory studies suggest that focusing on the PTM of PD-1 has strong therapeutic potential and can enhance the response to anti-PD-1.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 6Gene Fusion from Cancerous T Cells May Boost T-Cell Therapy - 1 month(s) ago
Incorporating a genetic change that cancerous T cells use to stay alive and grow may make T-cell therapies better cancer killers, a study in mice shows.
Source: www.cancer.govCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 37New drug could unlock benefits of immunotherapy for more patients - 1 month(s) ago
A new drug could offer a powerful way to sensitise tumours to immunotherapy, a new trial suggests.
Source: www.icr.ac.ukCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 18
The microbiome can identify those who benefit from combination immunotherapy across multiple different cancers, including rare gynecological cancers, biliary tract cancers and melanoma.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
New review in the April 15 issue: Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve #Immunotherapy Efficacy, by @GiuliaPetroni10 et al. https://t.co/9EODpxPylk @UNI_FIRENZE https://t.co/FaRnuqWRjO