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Mashup Score: 0
Setmelanotide resulted in significant bodyweight reductions in patients with Bardet-Biedl syndrome; however, these results were inconclusive in patients with Alström syndrome. These results support the use of setmelanotide and provided the necessary evidence for approval of this drug as the first treatment for obesity in patients with Bardet-Biedl syndrome.
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Mashup Score: 0
In The Lancet Diabetes & Endocrinology, Andrea Haqq and colleagues1 report on the safety and efficacy of setmelanotide at 52 weeks in patients with Bardet-Biedl syndrome and Alström syndrome in a phase 3, open-label trial with an initial, randomised, double-blind, placebo-controlled period.
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Mashup Score: 0
In The Lancet Diabetes & Endocrinology, Andrea Haqq and colleagues1 report on the safety and efficacy of setmelanotide at 52 weeks in patients with Bardet-Biedl syndrome and Alström syndrome in a phase 3, open-label trial with an initial, randomised, double-blind, placebo-controlled period.
Categories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 3Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction - 2 year(s) ago
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal chromosomal region, 15q11–13. Impaired hypothalamic development and function is the cause of most of the phenotypes comprising the developmental trajectory of Prader-Willi syndrome: from anorexia at birth to excessive weight gain preceding…
Categories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 0
In The Lancet Diabetes & Endocrinology, Andrea Haqq and colleagues1 report on the safety and efficacy of setmelanotide at 52 weeks in patients with Bardet-Biedl syndrome and Alström syndrome in a phase 3, open-label trial with an initial, randomised, double-blind, placebo-controlled period.
Categories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 3Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction - 2 year(s) ago
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal chromosomal region, 15q11–13. Impaired hypothalamic development and function is the cause of most of the phenotypes comprising the developmental trajectory of Prader-Willi syndrome: from anorexia at birth to excessive weight gain preceding…
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Mashup Score: 2Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction - 2 year(s) ago
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal chromosomal region, 15q11–13. Impaired hypothalamic development and function is the cause of most of the phenotypes comprising the developmental trajectory of Prader-Willi syndrome: from anorexia at birth to excessive weight gain preceding…
Categories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 1Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction - 2 year(s) ago
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal chromosomal region, 15q11–13. Impaired hypothalamic development and function is the cause of most of the phenotypes comprising the developmental trajectory of Prader-Willi syndrome: from anorexia at birth to excessive weight gain preceding…
Categories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 8Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction - 2 year(s) ago
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal chromosomal region, 15q11–13. Impaired hypothalamic development and function is the cause of most of the phenotypes comprising the developmental trajectory of Prader-Willi syndrome: from anorexia at birth to excessive weight gain preceding…
Categories: Endocrinology, Latest HeadlinesTweet
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Mashup Score: 1Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction - 2 year(s) ago
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal chromosomal region, 15q11–13. Impaired hypothalamic development and function is the cause of most of the phenotypes comprising the developmental trajectory of Prader-Willi syndrome: from anorexia at birth to excessive weight gain preceding…
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Online—Efficacy and safety of #setmelanotide, a #melanocortin-4 receptor agonist, in patients with #Bardet-Biedl syndrome and #Alström syndrome: a randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period https://t.co/84yoYMsYyi #obesity #hyperphagia