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Mashup Score: 4Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice - 2 day(s) ago
Key PointsCul5 regulates production of megakaryocyte-committed stem cells to prevent excess megakaryopoiesis.Cul5-deficient megakaryopoiesis is largely ind
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response - 1 month(s) ago
Key PointsDNMT3Amt CH is associated with an age- and comorbidity-independent negative impact on COVID-19–related inflammatory outcomes and survival.The neg
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
DNMT3Amt CH is associated with an age- and comorbidity-independent negative impact on COVID-19–related inflammatory outcomes and survival. https://t.co/5HdxrDuul2 #hematopoiesisandstemcells https://t.co/eFoySMbTRs
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Mashup Score: 19Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - 1 month(s) ago
Key PointsTyrosine-unphosphorylated STAT5 maintains HSCs.JAK inhibition promotes unphosphorylated STAT5 activity and maintains normal and myeloproliferativ
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
JAK inhibition promotes unphosphorylated STAT5 activity and maintains normal and myeloproliferative neoplasm HSPCs in mice and humans. https://t.co/HYXvH8dkgj #hematopoiesisandstemcells https://t.co/2EJVpsXrDt
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Mashup Score: 27Vitamin C deprivation puts stem cells to sleep - 2 month(s) ago
In this issue of Blood, Comazzetto et al1 demonstrate that vitamin C deprivation promotes stem cell quiescence and functionally reprograms multipotent hema
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Vitamin C deprivation puts stem cells to sleep https://t.co/5hqyoNGfm4 #hematopoiesisandstemcells https://t.co/OcBoF6y2rb
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Mashup Score: 39Stage-specific tuning of granulopoiesis by AK2 - 2 month(s) ago
In this issue of Blood, Wang et al1 report findings that significantly advance our understanding of the pathogenesis of reticular dysgenesis (RD), one of t
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Stage-specific tuning of granulopoiesis by AK2 https://t.co/cBdYZQHkm8 #hematopoiesisandstemcells https://t.co/2amIK10k99
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Mashup Score: 10Somatic symphony: telomeres and CH - 3 month(s) ago
In this issue of Blood, Gutierrez-Rodrigues et al1 characterize the spectrum of clonal hematopoiesis (CH) in a large international cohort of patients with
Source: ashpublications.orgCategories: General Medicine News, Hematologists1Tweet-
RT @BloodJournal: Somatic symphony: telomeres and CH https://t.co/mZ95DnFaty #hematopoiesisandstemcells https://t.co/kfY6oTqEg3
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Mashup Score: 17Catch ’em all! CDK9’s RUNX1 mega evolution - 4 month(s) ago
In this issue of Blood, Kwon et al1 provide evidence that posttranslational modification of the transcriptional factor RUNX1, through serine residue phosph
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Catch ’em all! CDK9’s RUNX1 mega evolution https://t.co/UJYesQuNLQ #hematopoiesisandstemcells https://t.co/nfLiAgI3U2
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Mashup Score: 30CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors - 5 month(s) ago
Key PointsPhospho-serine RUNX1 increases upon megakaryocytic fate specification, and phosphomimetic mutant RUNX1 promotes megakaryocytic fate in MEP.CDK9-i
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Phospho-serine RUNX1 increases upon megakaryocytic fate specification, and phosphomimetic mutant RUNX1 promotes megakaryocytic fate in MEP. https://t.co/Vnrm3NLpkr #hematopoiesisandstemcells https://t.co/hMtBJaCD6e
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Mashup Score: 23New frameworks for hematopoiesis derived from single-cell genomics - 6 month(s) ago
How the development of multiple lineages of mature blood cells from stem cells is regulated remains a fundamental question in hematology research, with a n
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
New frameworks for hematopoiesis derived from single-cell genomics https://t.co/W7SCXszke6 #hematopoiesisandstemcells https://t.co/BLSNTFQc2R
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Mashup Score: 32A new model of extramedullary hematopoiesis - 6 month(s) ago
In this issue of Blood, Schyrr et al report the development of a mouse model of extramedullary hematopoiesis (EMH) in the adrenal glands, which was useful
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
A new model of extramedullary hematopoiesis https://t.co/BkT3fXJON7 #hematopoiesisandstemcells https://t.co/2hKYzwfOG7
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Cul5-deficient megakaryopoiesis is largely independent of TPO and involves signaling via the β-common and/or β-IL-3 receptors. https://t.co/dgvchDnkzu #hematopoiesisandstemcells https://t.co/W25heBJO00