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Mashup Score: 19Russell body typhilitis: An unusual mimicker of malignancy! - 6 hour(s) ago
Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here a case of Russell body typhilitis in a middle-aged woman on neoadjuvant chemotherapy for breast carcinoma. The first case of Russell body-containing lesion of the gastrointestinal tract (GI) was documented in the stomach, in 1998. Since then, around 40 cases have been reported, most of which involve the upper GI tract.1 They are most frequently identified in the stomach as Russell body gastritis and have been associated with Helicobacter pylori infection.2 Some reports have linked them to immunosuppressive state and occasional cases have been found inadvertently in adjacent mucosa in gastric carcinoma. The patient age of Russell body lesions ranged from 24 to 88 years of age with a male-to-female ratio of 1.6:1.3 The first case of Russell body colitis was reported in the year 1999, in a 53-year-old woman.2 Out of the four cases described, two presented as colorecta
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 19Russell body typhilitis: An unusual mimicker of malignancy! - 9 day(s) ago
Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here a case of Russell body typhilitis in a middle-aged woman on neoadjuvant chemotherapy for breast carcinoma. The first case of Russell body-containing lesion of the gastrointestinal tract (GI) was documented in the stomach, in 1998. Since then, around 40 cases have been reported, most of which involve the upper GI tract.1 They are most frequently identified in the stomach as Russell body gastritis and have been associated with Helicobacter pylori infection.2 Some reports have linked them to immunosuppressive state and occasional cases have been found inadvertently in adjacent mucosa in gastric carcinoma. The patient age of Russell body lesions ranged from 24 to 88 years of age with a male-to-female ratio of 1.6:1.3 The first case of Russell body colitis was reported in the year 1999, in a 53-year-old woman.2 Out of the four cases described, two presented as colorecta
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
This is so cool! We bet you haven't seen this before! https://t.co/KHoX9fteAD #GIpath https://t.co/ozvSNFHHWW
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Mashup Score: 18Russell body typhilitis: An unusual mimicker of malignancy! - 11 day(s) ago
Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here a case of Russell body typhilitis in a middle-aged woman on neoadjuvant chemotherapy for breast carcinoma. The first case of Russell body-containing lesion of the gastrointestinal tract (GI) was documented in the stomach, in 1998. Since then, around 40 cases have been reported, most of which involve the upper GI tract.1 They are most frequently identified in the stomach as Russell body gastritis and have been associated with Helicobacter pylori infection.2 Some reports have linked them to immunosuppressive state and occasional cases have been found inadvertently in adjacent mucosa in gastric carcinoma. The patient age of Russell body lesions ranged from 24 to 88 years of age with a male-to-female ratio of 1.6:1.3 The first case of Russell body colitis was reported in the year 1999, in a 53-year-old woman.2 Out of the four cases described, two presented as colorecta
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
This is so cool! We bet you haven't seen this before! https://t.co/KHoX9fteAD #GIpath https://t.co/ozvSNFHHWW
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Mashup Score: 29Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists - 28 day(s) ago
Aims Interobserver variability in the assessment of gastric neoplasia biopsies between most Western and Eastern (predominantly represented by Japanese in the literature) pathologists has been documented. It is unknown if such variability exists between the US and Korean pathologists in the current era. Methods Ten gastrointestinal (GI) pathologists from the USA (n=5) and South Korea (n=5) evaluated 100 scanned images of gastric (n=50) and colorectal (n=50) neoplasia biopsies and answered multiple questionnaires. Consensus was defined as the answer chosen by the majority. Cohen’s (κc) and Fleiss’ kappa (κf) values were calculated between the consensus of the two groups and among the raters, respectively. Results Both groups reached a consensus in the majority of cases (74%–100%) with slight to perfect intergroup (κc=0.049–1.000) and no to substantial intragroup (κf=−0.083 to 0.660) agreements. For gastric neoplasia, Korean pathologists relied heavily on cytoarchitectural atypia, whereas
Source: jcp.bmj.comCategories: General Medicine News, General Journals & SocietTweet-
K-drama time😀 Test your skills with a group of US and Korean pathologists! Gastric biopsies. High-grade dysplasia or adenocarcinoma! #GIpath @stephen_lagana https://t.co/547jrdTdgE https://t.co/RVDbKWIuPn
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Mashup Score: 19Russell body typhilitis: An unusual mimicker of malignancy! - 8 month(s) ago
Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here a case of Russell body typhilitis in a middle-aged woman on neoadjuvant chemotherapy for breast carcinoma. The first case of Russell body-containing lesion of the gastrointestinal tract (GI) was documented in the stomach, in 1998. Since then, around 40 cases have been reported, most of which involve the upper GI tract.1 They are most frequently identified in the stomach as Russell body gastritis and have been associated with Helicobacter pylori infection.2 Some reports have linked them to immunosuppressive state and occasional cases have been found inadvertently in adjacent mucosa in gastric carcinoma. The patient age of Russell body lesions ranged from 24 to 88 years of age with a male-to-female ratio of 1.6:1.3 The first case of Russell body colitis was reported in the year 1999, in a 53-year-old woman.2 Out of the four cases described, two presented as colorecta
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
This is so cool! We bet you haven't seen this before! https://t.co/KHoX9fteAD #GIpath https://t.co/cKtcwU57Hz
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Mashup Score: 21Russell body typhilitis: An unusual mimicker of malignancy! - 9 month(s) ago
Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here a case of Russell body typhilitis in a middle-aged woman on neoadjuvant chemotherapy for breast carcinoma. The first case of Russell body-containing lesion of the gastrointestinal tract (GI) was documented in the stomach, in 1998. Since then, around 40 cases have been reported, most of which involve the upper GI tract.1 They are most frequently identified in the stomach as Russell body gastritis and have been associated with Helicobacter pylori infection.2 Some reports have linked them to immunosuppressive state and occasional cases have been found inadvertently in adjacent mucosa in gastric carcinoma. The patient age of Russell body lesions ranged from 24 to 88 years of age with a male-to-female ratio of 1.6:1.3 The first case of Russell body colitis was reported in the year 1999, in a 53-year-old woman.2 Out of the four cases described, two presented as colorecta
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
This is so cool! We bet you haven't seen this before! https://t.co/KHoX9fteAD #GIpath https://t.co/cKtcwU57Hz
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Mashup Score: 27Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon - 11 month(s) ago
Aim Micropapillary carcinoma (MPC) is a recognised WHO variant of colonic carcinoma (CC), although little is known about its prognosis, immune microenvironment and molecular alterations. We investigated its clinical, pathological and immunological characteristics. Methods We assessed 903 consecutive CCs and used the WHO definition to identify MPC. We recorded serrated and mucinous differentiation and mismatch repair (MMR) status. We performed immunohistochemistry and quantification on tissue microarrays for HLA class I/II proteins, beta-2-microglobulin (B2MG), CD8, CD163, LAG3, PD-L1, FoxP3, PD-L1and BRAF V600E. Results We classified 8.6% (N=78) of CC as MPC. Relative to non-MPC, MPC was more often high grade (p=0.03) and showed serrated morphology (p<0.01); however, we found no association with extramural venous invasion (p=0.41) and American Joint Committee on Cancer stage (p=0.95). MPCs showed lower numbers of CD8 positive lymphocytes (p<0.01), lower tumour cell B2MG expression (p=0
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
If you read @Vik_deshpandeMD et al https://t.co/d7WvGfO90N on micropapillary Colon CA, check out this hot-off-the-press 🔥🔥 editorial by @RaulSGonzalezMD describing the diagnostic criteria & his reporting approach to subtypes of colonic carcinoma https://t.co/Dul9w9cVvX #gipath https://t.co/sMhIIkJ0dr
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Mashup Score: 12Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays - 12 month(s) ago
Aim Pancreatic cyst fluid carcinoembryonic antigen (CEA) is a pivotal test in the diagnosis and management of neoplastic mucinous cysts (NMC) of the pancreas. Cyst fluid CEA levels of 192 ng/mL have been widely used to identify NMC. However, CEA values are unique to and significantly differ between individual assays with various optimal cutoffs reported in the literature for NMC. Here, we investigate the optimal CEA cut-off value of pancreatic cysts from two different assays to identify differences in thresholds. Methods Pancreatic cyst fluid CEA levels, CEA assay platform (Beckman Dxl (BD) or Siemens Centaur XP (SC)), and clinical/pathological information were retrospectively collected. Cases were categorised into either NMC or non-NMC. Optimal CEA cut-off values were calculated via a receiver operator characteristic curve. Cut-off values were then identified separately by assay platform. Results In total, 149 pancreatic cystic lesions with concurrent CEA values (SC: n=47; BD: n=102)
Source: jcp.bmj.comCategories: General Medicine News, General HCPsTweet-
Identifies at a transected margin of the pancreas by one of our Editors! Cancer anyone? #Gipath Some recently published papers - pancreas👇 https://t.co/03qoQkbQax https://t.co/QnLNGGQEz3 https://t.co/dd2CVilIJd https://t.co/YX1v8s5ZEw PS right is an AI-generated version😀 https://t.co/hcUWDJwaHV
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Mashup Score: 29Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists - 12 month(s) ago
Aims Interobserver variability in the assessment of gastric neoplasia biopsies between most Western and Eastern (predominantly represented by Japanese in the literature) pathologists has been documented. It is unknown if such variability exists between the US and Korean pathologists in the current era. Methods Ten gastrointestinal (GI) pathologists from the USA (n=5) and South Korea (n=5) evaluated 100 scanned images of gastric (n=50) and colorectal (n=50) neoplasia biopsies and answered multiple questionnaires. Consensus was defined as the answer chosen by the majority. Cohen’s (κc) and Fleiss’ kappa (κf) values were calculated between the consensus of the two groups and among the raters, respectively. Results Both groups reached a consensus in the majority of cases (74%–100%) with slight to perfect intergroup (κc=0.049–1.000) and no to substantial intragroup (κf=−0.083 to 0.660) agreements. For gastric neoplasia, Korean pathologists relied heavily on cytoarchitectural atypia, whereas
Source: jcp.bmj.comCategories: General Medicine News, General Journals & SocietTweet-
K-drama time😀 Test your skills with a group of US and Korean pathologists! Gastric biopsies. High-grade dysplasia or adenocarcinoma! #GIpath @stephen_lagana https://t.co/547jrdTdgE https://t.co/RVDbKWIuPn
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Mashup Score: 13S100 Protein Expression in Primary and Metastatic... : The American Journal of Surgical Pathology - 1 year(s) ago
patients. S100 protein is a commonly used marker in many laboratories for the identification of neural and melanocytic neoplasms and occasionally used in the workup for neuroendocrine neoplasms when the diagnosis of paraganglioma is being considered. We show that strong S100 protein expression is highly specific to well-differentiated neuroendocrine tumors of pancreatic origin. This finding suggests potential diagnostic utility of this marker in cases of tumors of unknown origin, and emphasizes that S100 protein expression should not be an unexpected finding in neuroendocrine tumors of pancreatic origin….
Source: journals.lww.comCategories: General Medicine News, Hem/OncsTweet-
TIL: S100 Protein Expression in Primary and Metastatic Neuroendocrine Neoplasms - A Specific Marker of Pancreatic Origin! #GIPath https://t.co/ssm7Zon2zu
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This is so cool! We bet you haven't seen this before! https://t.co/KHoX9fteAD #GIpath https://t.co/ozvSNFHHWW