• Mashup Score: 2
    Overdose of Novel Potent Opioids Requires More Naloxone - 8 month(s) ago

    The finding that novel potent opioids require more naloxone to reverse an overdose suggests these drugs are more potent than fentanyl and heroin, researchers say.

    Source: www.medscape.com
    Categories: General Medicine News, Latest Headlines
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      Medscape

      Patients presenting at the emergency department with an overdose of a nonfentanyl #opioid — referred to as a "novel potent opioid" (NPO) — require more #naloxone compared with those who overdose on #fentanyl, new research shows. https://t.co/DRXmgVaJ9U

  • Mashup Score: 71
    stats - 9 month(s) ago

    Fentanyl is a synthetic opioid that is up to 50 times stronger than heroin and 100 times stronger than morphine. It is a major contributor to fatal and nonfatal overdoses in the U.S. 1 There are two types of fentanyl: pharmaceutical fentanyl and illegally made fentanyl. Both are considered synthetic opioids. Pharmaceutical fentanyl is prescribed by doctors to treat severe pain, especially after surgery and for advanced-stage cancer. Howe ver, most recent cases of fentanyl-related overdose are linked to

    Source: www.cdc.gov
    Categories: General Medicine News, Latest Headlines
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      CDCgov

      Fentanyl is a deadly synthetic #opioid that’s often illegally made to look like other drugs. It’s the most common drug involved in #overdose deaths.    This National #FentanylPrevention and Awareness Day, learn more about the dangers of #fentanyl: https://t.co/fH7Fbu7rc6 https://t.co/kDDLt15KKX

  • Mashup Score: 8
    An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression - 9 month(s) ago

    The opioid overdose crisis primarily driven by potent synthetic opioids resulted in more than 500,000 deaths in the US over the last 20 years. Though naloxone, a short-acting medication, remains the primary treatment option for temporarily reversing opioid overdose effects, alternative countermeasures are needed. Monoclonal antibodies present a versatile therapeutic opportunity that can be tailored to synthetic opioids and help prevent post-treatment renarcotization. The ultrapotent analog carfentanil is especially concerning due to its unique pharmacological properties. With this in mind, we generated a fully human antibody through a drug-specific B cell sorting strategy with a combination of carfentanil and fentanyl probes. The resulting pan-specific antibody was further optimized through scFv phage display, producing C10-S66K. This monoclonal antibody displays high affinity to carfentanil, fentanyl, and other analogs and reversed carfentanil-induced respiratory depression. Additiona

    Source: pubs.acs.org
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      medical_xpress

      #Humanantibody that targets carfentanil, #fentanyl and related opioids reverses overdose effects in preclinical study https://t.co/BuFfggcfTp https://t.co/KaReipzZ9S

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      NeuroscienceNew

      “An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression” by Kim D. Janda et al. ACS Chemical Neuroscience https://t.co/jfKq7E9GWF 2/2

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