• Mashup Score: 3

    The FDA has granted approval for dupilumab for the treatment of eosinophilic esophagitis for adult and pediatric patients aged 12 years and older, according to a press release.Dupilumab (Dupixent, Regeneron Pharmaceuticals, Inc.) is the first drug in the U.S. specifically indicated for the treatment of this condition.

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    Healio Gastroenterology | Over the years, there have been many advances in the pathologic understanding of eosinophilic esophagitis, but FDA-approved treatment options have lagged.In a review published in the Journal of Allergy and Clinical Immunology, researchers noted that current treatments are considered off-label and include the three Ds: drugs, dietary elimination and endoscopic dilation.

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    Budesonide oral suspension improved histologic, endoscopic and symptom response compared with placebo among pediatric patients with eosinophilic esophagitis, according to a study. “Budesonide oral suspension (BOS) is an immediate-release swallowed topical corticosteroid optimized as a viscous suspension for patients with EoE,” Sandeep K. Gupta, MD, of the section of

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    • #Budesonide oral suspension improved histologic, endoscopic and symptom response compared with placebo among pediatric patients with #eosinophilicesophagitis #NASPGHAN21 #GITwitter @NASPGHAN https://t.co/hfrcFon8u2

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    Compared with adult patients who more frequently experienced delayed eosinophilic esophagitis diagnosis, pediatric patients had higher endoscopic findings of the disease with increased eosinophils detected during esophageal biopsy. “Incidence and prevalence of EoE has sharply increased in the last few years. Currently, EoE is the most frequent eosinophilic gastrointestinal disorder with a

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  • Mashup Score: 2

    Compared with adult patients who more frequently experienced delayed eosinophilic esophagitis diagnosis, pediatric patients had higher endoscopic findings of the disease with increased eosinophils detected during esophageal biopsy. “Incidence and prevalence of EoE has sharply increased in the last few years. Currently, EoE is the most frequent eosinophilic gastrointestinal disorder with a

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    • Compared with adult patients, pediatric patients had higher endoscopic findings of #eosinophilicesophagitis with increased eosinophils detected during esophageal biopsy #UEGWeek #GITwitter #MedTwitter https://t.co/aQScZPJBMT

  • Mashup Score: 1

    Compared with placebo, dupilumab was safe and improved eosinophilic esophagitis at 24 and 52 weeks, according to a presentation at UEG Week Virtual. “Current treatment options [for EoE] lack specificity, present adherence challenges and may offer suboptimal long-term disease control,” Evan S. Dellon, MD, MPH, of the University of North Carolina School of Medicine at Chapel Hill, said.

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    • Compared with placebo, #dupilumab was safe and improved #eosinophilicesophagitis at 24 and 52 weeks #GITwitter #MedTwitter #UEGWeek https://t.co/fQNteYf2kW