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Mashup Score: 24Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens - 2 day(s) ago
To accelerate CRISPR-based targeting of RNA, Guo et al. present a resource with optimized RfxCas13d guide RNAs (gRNAs) to target messenger RNAs and noncoding RNAs in six common model organisms and four RNA virus families. An accompanying open access web-based platform and design tool enable optimal gRNA design for any RNA target.
Source: www.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 41
Cas12a allows for easy multiplexing of guide RNAs in a single construct. CRISPRa, in which transactivation domains are used to overexpress endogenous genes, has been optimized using Cas9 but not Cas12a. Griffith et al. optimize Cas12a-based CRISPRa and demonstrate that recruitment using the ALFA tag and a corresponding nanobody enables potent gene activation across multiple genes simultaneously. Then, they perform genome-wide Cas12a-based CRISPRa screens, compare results with screens using other technologies, and derive guidelines for library design.
Source: www.cell.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 21
Now is the time for anyone involved in this field to embrace the best tools available for determining that a CRISPR edit will not harm the patients we are trying to help.
Source: www.genengnews.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 8
Synthego announced that it will focus solely on the therapeutic applications of CRISPR while spinning off a new company, EditCo Bio, which is positioned to deliver edited cells and highly optimized guide RNA designs for customer needs across both basic research and preclinical phases of CRISPR-based therapy.
Source: www.genengnews.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 8
Synthego announced that it will focus solely on the therapeutic applications of CRISPR while spinning off a new company, EditCo Bio, which is positioned to deliver edited cells and highly optimized guide RNA designs for customer needs across both basic research and preclinical phases of CRISPR-based therapy.
Source: www.genengnews.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 73
Massachusetts General Hospital surgeons announced that, for the first time, they had transplanted a kidney from a CRISPR gene-edited pig into a living patient.
Source: www.statnews.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 73
Massachusetts General Hospital surgeons announced that, for the first time, they had transplanted a kidney from a CRISPR gene-edited pig into a living patient.
Source: www.statnews.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 10Scientists say they can cut HIV out of cells - 2 month(s) ago
The gene-editing method used might ultimately offer a way to remove HIV, experts say.
Source: www.bbc.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 258CRISPR gene therapy seems to cure dangerous inflammatory condition - 2 month(s) ago
Nine out of ten people in a trial of a CRISPR treatment for potentially life-threatening inflammatory reactions seem to have been cured
Source: www.newscientist.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 171CRISPR engineered viruses could render other viruses harmless - 2 month(s) ago
A virus engineered using CRISPR technology spread its DNA to other viruses in mice, which could be used to make viral pathogens harmless
Source: www.newscientist.comCategories: General Medicine News, Future of MedicineTweet
Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens https://t.co/wO6Qa30MKT @nevillesanjana @CathyxGuo @jahanpehechanho @we_harm @alexmenman @nygenome @nyuniversity @nyugrossman Up-and-coming genomics research from @CellGenomics #CRISPR