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Mashup Score: 1Liquid biopsies to monitor and direct cancer treatment in colorectal cancer - British Journal of Cancer - 2 year(s) ago
Colorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide. Despite recent improvements in treatment and prevention, most of the current therapeutic options are weighted by side effects impacting patients’ quality of life. Better patient selection towards systemic treatments represents an unmet clinical need. The recent multidisciplinary and molecular advancements in the…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
“Our case discussion for January 18 is going to be focused on a patient who initially has biochemically recurrent prostate cancer [and] progresses to metastatic disease,” says Veda N. Giri, MD.
Source: Urology TimesCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
SKCC's Dr. @vedangiri offered @UrologyTimes a preview of the upcoming ENGAGEMENT Study Virtual Genetics Board’s case discussion focusing on new data on TP53 mutations and #ProstateCancer risk, as well as TP53-related management: https://t.co/5b44csypc1 #CancerGenetics #pcsm
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Mashup Score: 1Engagement Landing — Clinical Genetics Research Studies - 2 year(s) ago
Thomas Jefferson University ENGAGEMENT Virtual Genetics Board …
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Join us for the next ENGAGEMENT Study Virtual Genetics Board on 1/18 at noon ET. To join, pre-register at https://t.co/839Qagz0Fb. #ProstateCancer #pcsm #CancerGenetics https://t.co/cfha7BRzjl
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Mashup Score: 4Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups - 2 year(s) ago
Prostate cancer is the second most common solid tumour in men worldwide and it is also the most common cancer affecting men of African descent. Prostate cancer incidence and mortality vary across regions and populations. Some of this is explained by a large heritable component of this disease. It has been established that men of African and African Caribbean ethnicity are predisposed to prostate…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups Read for free with #SharedIt: https://t.co/2ApKUjYNlk #Cancergenetics #Cancergenomics https://t.co/MqiqMNiaA1
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Mashup Score: 1Isocitrate dehydrogenase mutations are associated with altered IL-1β responses in acute myeloid leukemia - 2 year(s) ago
Mutations in isocitrate dehydrogenase 2 (IDH2) have been noted to impact cellular differentiation in addition to DNA and histone methylation. However, little is known about the impact of IDH2 mutations on intracellular signaling. Using an isogenic cell line model, we investigated both differentiation and signaling responses in IDH2 mutant cells and show augmented responses to inflammatory immune…
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Isocitrate dehydrogenase mutations are associated with altered IL-1β responses in acute myeloid leukemia Read for free with #SharedIt: https://t.co/07TxhEWIIl #Acutemyeloidleukaemia #Cancergenetics #Cellsignalling https://t.co/yb8I7mEhCE
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Mashup Score: 9Comprehensive epithelial tubo-ovarian cancer risk prediction model incorporating genetic and epidemiological risk factors - 2 year(s) ago
Background Epithelial tubo-ovarian cancer (EOC) has high mortality partly due to late diagnosis. Prevention is available but may be associated with adverse effects. A multifactorial risk model based on known genetic and epidemiological risk factors (RFs) for EOC can help identify women at higher risk who could benefit from targeted screening and prevention. Methods We developed a multifactorial…
Source: Journal of Medical GeneticsCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
New model, including rare variants, PRS & epidemiological data, allows individualised risk prediction in #OvarianCancer #OpenAccess here: https://t.co/lTAcKCP3t1 @paulpharoah @ProfManchanda @Prof_UMenon @lawrensonlab @eveappeal @geneticcounsel #GCChat #Cancer #CancerGenetics https://t.co/rnFCmVPKUL
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Mashup Score: 1Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9 - Leukemia - 2 year(s) ago
To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord blood samples, with CRISPR/Cas9 technology. Site-specific mutations were introduced in defined regions of DNMT3A, TET2, and ASXL1 in CD34+ progenitor…
Source: LeukemiaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9 Read for free: https://t.co/VjzcwWQ1fi #Cancergenetics #Myelodysplasticsyndrome https://t.co/pdEyOoHTxf
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Mashup Score: 1Long non-coding RNAs are involved in alternative splicing and promote cancer progression - British Journal of Cancer - 3 year(s) ago
Alternative splicing (AS) is a key process in which precursor RNAs produce different mature RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared with coding RNA, studies on the functions of long non-coding RNAs (lncRNAs) are far from enough. In fact, lncRNA is an important participant and regulator in the process of AS. On the one hand, lncRNAs regulate cancer…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Long non-coding RNAs are involved in alternative splicing and promote cancer progression Read for free: https://t.co/by4XjmBeJh #Cancergenetics #NoncodingRNAs https://t.co/LUAfhOFt7a
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Mashup Score: 0Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease - British Journal of Cancer - 3 year(s) ago
The plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNA gene involved in human disease, mainly in cancer onset/progression. Although widely analysed, its biological roles need to be further clarified. Notably, functional studies on PVT1 are complicated by the occurrence of multiple transcript variants, linear and circular, which generate technical issues in the experimental…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease Read for free: https://t.co/odeCsAAeCe #Cancergenetics #Tumourbiomarkers https://t.co/vlGOq3FRNf
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Mashup Score: 1How a Hereditary Multicancer Syndrome Was Discovered, December 2012 Linkage Newsletter - 3 year(s) ago
Li-Fraumeni Syndrome (LFS) is a rare, inherited disorder which leads to a higher risk of certain cancers. NCI has evaluated families with LFS since the syndrome was first recognized in 1969 by Dr. Fred Li and Dr. Joseph Fraumeni. DCEG is now expanding this research through a clinical study and participation in a multi-institutional collaboration.
Source: National Cancer InstituteCategories: Latest Headlines, Oncologists2Tweet-
What a great tribute to giants in #CancerGenetics! https://t.co/bwJEkBmkpS @AndrienneWilson @canpreventmvmt #KnowYourGenes #LFS #CancerPrevention #BetterThanCure #CancerFreeWorld
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Liquid biopsies to monitor and direct cancer treatment in colorectal cancer Read for free: https://t.co/IiuRJ6St9t #Cancergenetics #Tumourbiomarkers https://t.co/U5rA3hHIlh