-
Mashup Score: 0
8543 Background: Obesity has been implicated as a risk factor for the development of certain types of cancers, including multiple myeloma. Previous studies in other tumor types suggest that overweight subjects may have better outcomes, however, in relapsed/refractory multiple myeloma (RRMM), it is unknown whether body weight affects outcomes to therapy. Methods: We conducted a retrospective…
Source: Journal of Clinical OncologyCategories: Hem/Oncs, Latest HeadlinesTweet
-
Mashup Score: 0Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study - 2 year(s) ago
Key Points. Obesity is not associated with MGUS or LC-MGUS.High body mass index during midlife is associated with increased risk of progressing from MGUS and LC
Source: American Society of HematologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Obesity & risk of MGUS & progression to multiple myeloma: a population-based study [11/14/17] Thordardottir et al. @BloodAdvances https://t.co/UIlBYwbXI3 #mmsm #cametab High midlife BMI increased risk MGUS -> MM w/ HR 2.66
-
-
Mashup Score: 0Source: academic.oup.comCategories: Hem/Oncs, Latest HeadlinesTweet
-
Obesity & the Transformation of Monoclonal Gammopathy of Undetermined Significance [MGUS] to Multiple Myeloma: A Population-Based Cohort Study [Dec 31, 2016] Chang et al. @JNCI_Now https://t.co/3uwC8GDKMF #mmsm #cametab n=7878 MGUS. Weight measured one month +/- MGUS Dx
-
-
Mashup Score: 0Leisure-Time Physical Activity and Risk of 26 Types of Cancer - 2 year(s) ago
This study of pooled data from 12 US and European cohorts examines the association of leisure-time physical activity with incidence of 26 common types of cancer and whether the associations vary by body size and/or smoking.
Source: jamanetwork.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Leisure-Time Physical Activity Assoc w/ 26 Cancers in 1.44M Adults [6/2016] Moore et al. @JAMAInternalMed https://t.co/v6H53QBFN6 #cametab
-
Myeloma (HR, 0.83; 95% CI, 0.72-0.95) -> Leisure-Time Physical Activity Assoc w/ 26 Cancers [6/2016] https://t.co/v6H53QBFN6 #cametab #mmsm
-
-
Mashup Score: 0
Disease-related weight loss may be an important and heretofore unknown indicator of poor prognosis in MM. Assessment of weight loss prior to MM diagnosis should become a standard component of the clinical history in patients with newly diagnosed MM. Further research may identify relationships betwee …
Source: PubMedCategories: Hem/Oncs, Latest HeadlinesTweet-
Influence of body mass index (BMI) on survival in veterans with multiple myeloma [2013] Beason et al. @OncJournal https://t.co/qwMqoo1ONd #mmsm #cametab
-
-
Mashup Score: 0Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women - 2 year(s) ago
Abstract. Obesity and black race have been associated with excess risk of multiple myeloma. The association of obesity with monoclonal gammopathy of undetermine
Source: American Society of HematologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance [MGUS] among black and white women [Aug 19, 2010] @DrOlaLandgren @VincentRK et al. @BloodJournal https://t.co/DHUATPZ94d #mmsm #cametab
-
Multivariate risks MGUS = obesity (OR =1.8; P=.04), black race (OR= 1.8; P=.04), incr age (OR=2.5; P=.03) https://t.co/DHUATPZ94d 2010 #mmsm #cametab
-
-
Mashup Score: 0
Multiple myeloma (MM) remains an incurable plasma cell malignancy. Although little is known about the etiology of MM, several metabolic risk factors such as obesity, diabetes, poor nutrition, many of which are modifiable, have been linked to the pathogenesis of numerous neoplasms including MM. In this article, we provide a detailed summary of what is known about the impact of obesity on the…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
A comprehensive review of the impact of obesity on plasma cell disorders [Oct 15, 2021] @richaparikh36 @maaztariqsyed Marinac & @UrviShahMD @LeukemiaJnl https://t.co/rjlXSuRJ6h #mmsm #cametab
-
-
Mashup Score: 2Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma - 2 year(s) ago
The efficacy of mutant IDH1 inhibition in a genetically engineered mouse model of cholangiocarcinoma is mediated by stimulation of cytotoxic T-cell function and derepression of TET2 in tumor cells, which epigenetically resensitizes tumor cells to IFNγ.
Categories: Hem/Oncs, Latest HeadlinesTweet-
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma [Mar 8, 2022] @itsacurse et al. @BCD_AACR https://t.co/QFtLZn085q #PrecisionMedicine #ImmunoOnc #hpbcsm #cametab
-
-
Mashup Score: 1Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma - 2 year(s) ago
The efficacy of mutant IDH1 inhibition in a genetically engineered mouse model of cholangiocarcinoma is mediated by stimulation of cytotoxic T-cell function and derepression of TET2 in tumor cells, which epigenetically resensitizes tumor cells to IFNγ.
Categories: Hem/Oncs, Latest HeadlinesTweet-
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma [Mar 8, 2022] @itsacurse et al. @BCD_AACR https://t.co/QFtLZn085q #PrecisionMedicine #ImmunoOnc #hpbcsm #cametab https://t.co/nXN2q5tuS8
-
-
Mashup Score: 1Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma - Nature Communications - 3 year(s) ago
Metabolic reprogramming occurs during tumor progression. Here the authors decipher metabolic trajectories from preneoplasia to lung adenocarcinoma in tumor samples and identify plasma metabolites as potential predictive biomarkers for early detection.
Source: Nature CommunicationsCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Comprehensive characterization of the metabolic evolution along the development of lung adenocarcinoma reveals 3 predictive panels of metabolites that might provide opportunities for improved early detection, prognostication & therapy: https://t.co/YJj68sSq1y #lcsm #cametab
-
FDA analysis: Impact of BMI on efficacy outcomes in multiple myeloma trials - Rachel Ershler et al. #ASCO20 Abstract: 8543, Poster: 443 https://t.co/uctnCOpehT #cametab #mmsm @FDAOncology https://t.co/G8ZXewpLsB