-
Mashup Score: 3
In a recent study, participants had highest gout flare rates when serum urate levels were > 10 mg/dL and the lowest gout flare when levels were < 3.9 mg/dL.
Source: www.hcplive.comCategories: General Medicine News, RheumatologyTweet
-
Mashup Score: 3
In a recent study, participants had highest gout flare rates when serum urate levels were > 10 mg/dL and the lowest gout flare when levels were < 3.9 mg/dL.
Source: www.hcplive.comCategories: General Medicine News, RheumatologyTweet-
#BWHRheumatology @SaraKTedeschi Gout flare rates were persistently higher when SU ≥6 mg/dL compared to SU at target after the first year of ULT. https://t.co/zKKmUOh4Dk
-
-
Mashup Score: 0A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities - 7 month(s) ago
Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of common variants outside …
Source: www.atsjournals.orgCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology studied role of common genetic variants in identifying idiopathic pulmonary fibrosis (IPF) and interstitial lung abnormalities (ILA) risk. Polygenic risk scores (PRS) w/o MUC5B region associated w/ IPF, ILA, and ILA progression. https://t.co/3DUSXZnU4I #genetics https://t.co/Aaloi2FmBx
-
-
Mashup Score: 0Comparative safety and effectiveness of TNF inhibitors, IL6 inhibitors and methotrexate for the treatment of immune checkpoint inhibitor-associated arthritis - 10 month(s) ago
Objectives To compare the safety and effectiveness of biologic and conventional disease-modifying antirheumatic drugs (DMARDs) for immune checkpoint inhibitor-associated inflammatory arthritis (ICI-IA). Methods The retrospective multicentre observational study included patients with a diagnosis of ICI-IA treated with a tumour necrosis factor inhibitor (TNFi), interleukin-6 receptor inhibitor…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology studies safety & effectiveness of biologic & conventional DMARDs for ICI-inflammatory arthritis (ICI-IA). Treating ICI-IA w/ a biologic DMARD assoc. w/ quicker arthritis control but may be assoc. w/ shorter time to cancer progression. https://t.co/Cu7gG4LjYb https://t.co/PJcnORVzGD
-
-
Mashup Score: 0Immunocompromise and herpes simplex virus type 1 encephalitis (HSVE): a nationwide cohort and case-control study (S25.009) - 10 month(s) ago
Objective: We aim to determine whether a relationship exists between immunocompromise as defined by autoimmune disease or immunosuppressive and immunomodulatory medications in patients and incident HSVE. Background: Among infectious etiologies of encephalitis, herpes simplex virus type 1 (HSV-1) is commonest. The association between immune status and HSVE is unclear. Using a U.S. Medicaid…
Source: NeurologyCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology looks at relationship between #autoimmune disease, immunomodulatory meds and incident HSV encephalitis. Strong assoc. of HSVE w/ autoimmune conditions (HR 2.3) and exposure to immunomodulatory meds (HR 2.0). https://t.co/FXZHGAARDa https://t.co/hB08dGZYjd
-
-
Mashup Score: 0Reducing cardiovascular risk with immunomodulators: a randomised active comparator trial among patients with rheumatoid arthritis - 11 month(s) ago
Objective Recent large-scale randomised trials demonstrate that immunomodulators reduce cardiovascular (CV) events among the general population. However, it is uncertain whether these effects apply to rheumatoid arthritis (RA) and if certain treatment strategies in RA reduce CV risk to a greater extent. Methods Patients with active RA despite use of methotrexate were randomly assigned to…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology studies effects of immunomodulators on arterial inflammation in RA. Pts randomized to add a tumor necrosis factor inhibitor (TNFi) or sulfasalazine + hydroxychloroquine (triple therapy) to methotrexate. Both improved arterial inflammation. https://t.co/qcJgkQGG2s https://t.co/fFjsdDc2KU
-
-
Mashup Score: 2Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study - 11 month(s) ago
To estimate the effect of denosumab compared with oral bisphosphonates on reducing the risk of type 2 diabetes in adults with osteoporosis.Population based study involving emulation of a randomized target trial using electronic health records.IQVIA Medical …
Source: PubMed Central (PMC)Categories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology compares the effect of denosumab and oral bisphosphonate on the risk of type 2 #diabetes in adults with osteoporosis. Denosumab was associated with reduced risk of incident Type 2 diabetes (5.7/1000 p-yrs) compared to bisphosphonate (8.3). https://t.co/AfeUg6irCH https://t.co/7QF1ivHBh9
-
-
Mashup Score: 0Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis - 11 month(s) ago
Objective Calcium pyrophosphate deposition (CPPD) disease prevalence is similar to that of gout and osteoarthritis (OA), yet CPPD outcomes research greatly lags behind research in these other forms of arthritis. We compared validated patient-reported outcome measures in patients with CPPD vs gout and OA. Methods Patients with CPPD were recruited from Brigham and Women’s Hospital from 2018 to…
Source: The Journal of RheumatologyCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology investigates symptom severity in Calcium Pyrophosphate Deposition Disease (CPPD) through patient-reported outcomes. Pts w/ CPPD may experience pain comparable to #Gout and OA during flares, but report substantial unmet treatment needs. https://t.co/xElp1wUUuP https://t.co/fhn3ytuLLX
-
-
Mashup Score: 0Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis - PubMed - 12 month(s) ago
Patients taking FO supplements, regardless of RA status, not only had higher blood levels of EPA and DHA, but also of their enzymatic products 18-HEPE (E-series resolvin precursors), 15-HEPE and 17-HDHA (D-series resolvin and protectin precursors). Patients with RA, an inflammatory autoimmune diseas …
Source: PubMedCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology studies effect of fish oil on circulation of omega-3-derived specialized pro-resolving mediators (SPMs) & if #RA impacts it. Pts w/ & w/o RA taking FO had ⬆️ SPM substrates. Pts w/ RA may augment SPM substrate reserves by taking FO. https://t.co/nuUldxcnot https://t.co/FWp04pRulk
-
-
Mashup Score: 2Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis - 1 year(s) ago
Objectives Calcium pyrophosphate deposition (CPPD) disease, broadly defined, has been associated with increased risk of cardiovascular (CV) events. We investigated risk of CV events in patients with acute CPP crystal arthritis, the acute manifestation of CPPD. Methods Cohort study using Mass General Brigham electronic health record (EHR) data, 1991–2017. Patients with acute CPP crystal arthritis…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
#BWHRheumatology and @SaraKTedeschi investigate risks for CV events in pts w/ acute #CPP crystal arthritis in MGB EHR cohort. Short and long-term risk for CV events significantly higher in acute CPP crystal arthritis cohort vs. non-CPP comparators. https://t.co/DY5QuSYA91 https://t.co/CzZV7GvPhT
-
#BWHRheumatology @SaraKTedeschi Gout flare rates were persistently higher when SU ≥6 mg/dL compared to SU at target after the first year of ULT. https://t.co/zKKmUOh4Dk