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Mashup Score: 0Unraveling the Plastic Peripheral Neuroimmune Interactome - 1 year(s) ago
Abstract. Sensory neurons and immune cells share a common microenvironmental niche for surveying tissue integrity. The immune and nervous systems both sense dev
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Mashup Score: 1
Abstract. Nonhematopoietic cells are emerging as important contributors to many inflammatory diseases, including allergic asthma. Recent advances have led to a
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Mashup Score: 2Microbiota-Immune Interactions Regulate Metabolic Disease - 1 year(s) ago
Abstract. Metabolic diseases are common worldwide and include diseases of overnutrition, such as obesity, or undernutrition, such as kwashiorkor. Both the immun
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Mashup Score: 0Drosophila Toll Pathway in Innate Immunity: from the Core Pathway toward Effector Functions - 2 year(s) ago
Abstract. The fruit fly Drosophila melanogaster Toll signaling pathway has an evolutionarily conserved role in controlling immune responses. Whereas the microbi
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Mashup Score: 0Single-Cell Immunobiology of the Maternal–Fetal Interface - 2 year(s) ago
Pregnancy success requires constant dialogue between the mother and developing conceptus. Such crosstalk is facilitated through complex interactions between maternal and fetal cells at distinct tissue sites, collectively termed the “maternal–fetal interface.” The emergence of single-cell technologies has enabled a deeper understanding of the unique processes taking place at the maternal–fetal…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 3Stromal Cell–Mediated Coordination of Immune Cell Recruitment, Retention, and Function in Brain-Adjacent Regions - 2 year(s) ago
The CNS is tightly regulated to maintain immune surveillance and efficiently respond to injury and infections. The current appreciation that specialized “brain-adjacent” regions in the CNS are in fact not immune privileged during the steady state, and that immune cells can take up residence in more immune-privileged areas of the CNS during inflammation with consequences on the adjacent brain…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1Immune Cell–Stromal Circuitry in Lupus Photosensitivity - 2 year(s) ago
Photosensitivity is a sensitivity to UV radiation (UVR) commonly found in systemic lupus erythematosus (SLE) patients who have cutaneous disease. Upon even ambient UVR exposure, patients can develop inflammatory skin lesions that can reduce the quality of life. Additionally, UVR-exposed skin lesions can be associated with systemic disease flares marked by rising autoantibody titers and worsening…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 6Influenza Virus and SARS-CoV-2 Vaccines - 2 year(s) ago
Seasonal influenza and the current COVID-19 pandemic represent looming global health challenges. Efficacious and safe vaccines remain the frontline tools for mitigating both influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–induced diseases. This review will discuss the existing strategies for influenza vaccines and how these strategies have informed SARS-CoV-2…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 7RIG-I–like Receptor Regulation of Immune Cell Function and Therapeutic Implications - 2 year(s) ago
Retinoic acid–inducible gene I–like receptors (RLRs) are cytosolic RNA sensors critical for initiation of antiviral immunity. Activation of RLRs following RNA recognition leads to production of antiviral genes and IFNs for induction of broad antiviral immunity. Although the RLRs are ubiquitously expressed, much of our understanding of these molecules comes from their study in epithelial cells and…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 6Dietary Cholesterol Metabolite Regulation of Tissue Immune Cell Development and Function - 2 year(s) ago
Obesity is considered the primary environmental factor associated with morbidity and severity of wide-ranging inflammatory disorders. The molecular mechanism linking high-fat or cholesterol diet to imbalances in immune responses, beyond the increased production of generic inflammatory factors, is just beginning to emerge. Diet cholesterol by-products are now known to regulate function and…
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet
#ICYMI: #BriefReview from Clifford J. Woolf @BostonChildrens: The role of the peripheral #NeuroimmuneInteractome in health and disease | #ReadTheJI #immunology #neuroimmunology #pain #itch 👉 https://t.co/l0TlaL2ovF https://t.co/Lz7t1wEUV5