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Mashup Score: 10
PURPOSEAllogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for advanced hematologic malignancies. HSCT using human leukocyte antigen (HLA)-mismatched donors is historically associated with inferior survival. Patients from …
Source: ascopubs.orgCategories: General Medicine NewsTweet
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Mashup Score: 85Autologous Transplant or CAR‐T as Consolidation Options in MYC Rearranged Large B‐Cell Lymphoma Patients in Remission After Salvage Treatments - 2 month(s) ago
Although recent studies have demonstrated the efficacy of chimeric antigen receptor T-cell (CAR-T) therapy in relapsed large B-cell lymphoma (LBCL) with MYC rearrangement (R-MYC), the data comparing …
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet
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Mashup Score: 76Autologous Transplant or CAR‐T as Consolidation Options in MYC Rearranged Large B‐Cell Lymphoma Patients in Remission After Salvage Treatments - 3 month(s) ago
Although recent studies have demonstrated the efficacy of chimeric antigen receptor T-cell (CAR-T) therapy in relapsed large B-cell lymphoma (LBCL) with MYC rearrangement (R-MYC), the data comparing …
Source: onlinelibrary.wiley.comCategories: General Medicine NewsTweet
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Mashup Score: 6Taming JAK cytokine release in haplo-transplant - 3 month(s) ago
In this issue of Blood, Abboud and colleagues1 report the results of a phase 2 trial of itacitinib given as add-on to standard graft-versus-host disease (G
Source: ashpublications.orgCategories: General Medicine NewsTweet
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Mashup Score: 10Clonal dynamics after allogeneic haematopoietic cell transplantation - 8 month(s) ago
Nature – Uprooting stem cells from their native environment and transplanting them to other individuals exaggerates selective pressures, distorting and accelerating the loss of clonal diversity in…
Source: www.nature.comCategories: General Medicine News, Hematologists1Tweet
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Mashup Score: 1Revisiting Timing and Decision Modeling for Allogeneic Hematopoietic Stem-Cell Transplantation in Myelodysplastic Syndromes | Journal of Clinical Oncology - 10 month(s) ago
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.
Source: ascopubs.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Final outcomes from a phase 2 trial of posoleucel in allogeneic hematopoietic cell transplant recipients - 10 month(s) ago
Key PointsAllogeneic hematopoietic cell transplant recipients are at risk of clinically significant viral infections due to lack of T-cell immunity.The mul
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 8HA-1–targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation - 10 month(s) ago
Key PointsThis trial used a class I–restricted TCR and a CD8 coreceptor to enable antigen–specific CD8+ and CD4+ T-cell function.Primary end points of feas
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 61How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients - 10 month(s) ago
Organizing pneumonia (OP) after allogeneic hematopoietic stem cell transplant (HCT OP) is a major cause of severe morbidity and mortality and is usually as
Source: ashpublications.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9New insights into pregnancy after stem-cell transplantation - 10 month(s) ago
Many people diagnosed with haematological malignancies or who undergo a haematopoietic stem-cell transplantation (HSCT) must face the impact of their treatment on their future fertility. A new German registry study provides insight into the likelihood of pregnancy and live birth in 2654 women aged 18–40 years who had had an allogeneic HSCT to treat a range of conditions. 50 women had 74 pregnancies, and the annual first birth rate in recipients of an HSCT was 6-times lower than that of the general population at 0·45% (95% CI 0·31–0·59); however, 39 (72%) of 54 pregnancies occurred spontaneously without the need for assistive reproductive technology, providing evidence that pregnancy is possible after this treatment.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
Post-Transplant Cyclophosphamide-Based GVHD Prophylaxis After Mismatched Unrelated Donor PB SCT @JCO_ASCO https://t.co/dRzdlsnaaQ @DrMonzrAlMalki @amjimenezmd #bmtsm