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Mashup Score: 12Stroke Volume: The Primary Outcome Equalizer? - 23 hour(s) ago
Ischemic stroke lesion volume at follow-up is an important surrogate outcome in acute stroke trials. Multiple issues outside of the stroke itself (aspiration pneumonia, pulmonary embolism, etc.) can introduce noise in the clinical treatment effect of acute stroke care. Imaging outcomes soon after treatment help to avoid the confounding aspects of post-treatment care. It is currently not known what differences in infarct size at 48 hours are meaningful, and this study aimed to identify such values. The
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Mashup Score: 14
After a cryptogenic stroke, many patients undergo placement of an insertable cardiac monitor (ICM) to detect paroxysmal atrial fibrillation (AF). Because placement of an ICM is invasive, many patients are hesitant to und ergo the procedure. This study provides information about a patient population that might be more likely to benefit from placement of an ICM. In this article, the authors retrospectively reviewed cases of cryptogenic stroke who underwent ICM placement at 8 stroke centers in Japan from
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Mashup Score: 30Magnesium and ICH: More Work to Be Done - 17 day(s) ago
Studies have suggested a hemostatic role for magnesium in patients with intracerebral hemorrhage (ICH). A secondary analysis of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) trial did not show an association between treatment with magnesium and hematoma expansion (HE) or functional outcomes in patients with ICH. This analysis was confounded by imbalances in available data between the treatment and placebo groups and did not consider the effect of serum magnesium levels. Liotta et al.
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Mashup Score: 32Do Low Serum Albumin Levels Increase the Risk of Cardiovascular Events in Ischemic Stroke? - 25 day(s) ago
Albumin, in addition to its role in maintaining oncotic pressure, has a wide range of anti-inflammatory and antioxidant properties. 1 These functions could theoretically help prevent cardiovascular diseases with an inflammatory component, such as atherosclerosis. Several observational studies have reported increased risk of cardiovascular diseases in the general population with low vs normal serum albumin levels, 2 including coronary artery disease, 3 heart failure, 4 and atrial fibrillation. 5 The
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Mashup Score: 1Article Commentary: “Upregulated Cytoskeletal Proteins Promote Pathological Angiogenesis in Moyamoya Disease” - 1 month(s) ago
The present study, carried out by He and colleagues, aimed to investigate the potential impact of abnormally expressed serum proteins in the unclear pathogenesis of Moyamoya disease (MMD). MMD is a rare cerebrovascular disorder, characterized by progressive steno-occlusive lesions of the terminal part of the internal carotid artery and the development of a fragile vascular network at the base of the brain. Typically, patients affected by MMD run into ischemic and hemorrhagic strokes. The key trigge ring
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Mashup Score: 18Do Higher Transferrin Saturation and Iron Levels Cause Poorer Functional Outcomes in Ischemic Stroke? - 1 month(s) ago
Iron is essential for a wide range of physiological processes, such as erythropoiesis and immune regulation. The effect of iron deficiency on prognosis in cardiovascular diseases such as heart failure has received increasing attention, partly because it is highly prevalent, readily quantifiable in routine practice, and potentially modifiable. 1,2 The few observational studies exploring the effect of iron status on prognosis and recovery after stroke, however, yielded conflicting results. 1 Inconsistent
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Mashup Score: 45Article Commentary: “Dental Caries, Race and Incident Ischemic Stroke, Coronary Heart Disease, and Death” - 1 month(s) ago
When counseling stroke patients on risk factor modification, we routinely discuss monitoring blood sugars, blood pressures, and smoking cessation, but this study by Sen et al. suggests we should be discussing adequate dental care, also. The authors sought to determine if there was a relationship between dental caries and stroke, coronary heart disease and death. They used data from the Atherosclerosis Risk in Communities (ARIC) data set. These patients were collected starting in 1987 from North Carolina,
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Mashup Score: 14Article Commentary: “Arterial Stiffness Is Associated With Small Vessel Disease Irrespective of Blood Pressure in Stroke-Free Individuals” - 1 month(s) ago
Hypertension is one of the leading risk factors for cerebral small vessel disease (CSVD). Arterial stiffness, measured noninvasively by pulse wave velocity (PWV), is closely related to hypertension and is an important risk factor for CSVD. Whether the impact on CSVD differs in individuals with different BP and arterial stiffness statuses has not been examined. The authors sought to determine the effects of arterial stiffness on CSVD in normotensive individuals by conducting a cross-sectional study in
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Mashup Score: 13Interactions Between Environmental and Genetic Risk Factors for Stroke: The Example of Particulate Matter - 1 month(s) ago
Social and environmental determinants of health are systemic structures and conditions upstream of one’s intrinsic biological and behavioral predisposition that influence health, functioning, and quality of life. Outdoor air pollution is an environmental determinant of health composed of gases (e.g., nitrogen oxides) and particulate matter (PM) that increases the risk of lung and cardiovascular diseases, especially in the elderly. 1 The fraction of PM < 2.5 micrometers in diameter (PM 2.5) is a measurement
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Mashup Score: 20
Qinglan “Priscilla” Ding, MBBS, PhD @QDing3 Historically, managing blood glucose levels after acute stroke has been a delicate balance — too high, and the risk of complications rises; too low, and patients could face a whole new set of challenges. Insulin has been a go-to treatment, but it’s not without its problems. Enter a potential game-changer: GLP-1RAs (glucagon-like peptide 1 receptor agonists), a group of drugs that have already shown promise for glucose control among people with type 2 diabetes.
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Stroke Volume: The Primary Outcome Equalizer? In this #BloggingStroke post, Mitchell Silver discusses #Stroke article by Rinkel & @johanna_ospel et al. @mihill68 @TudorGJovin @mayank_G0 https://t.co/x3jOhrGtis https://t.co/vrB1Bd7CgB