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Mashup Score: 20
Qinglan “Priscilla” Ding, MBBS, PhD @QDing3 Historically, managing blood glucose levels after acute stroke has been a delicate balance — too high, and the risk of complications rises; too low, and patients could face a whole new set of challenges. Insulin has been a go-to treatment, but it’s not without its problems. Enter a potential game-changer: GLP-1RAs (glucagon-like peptide 1 receptor agonists), a group of drugs that have already shown promise for glucose control among people with type 2 diabetes.
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Mashup Score: 34Article Commentary: “Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke” - 2 month(s) ago
Non-contrast computed tomography (CT) is the standard imaging modality for identifying an intracerebral hemorrhage (ICH) in the acute setting. Standard magnetic resonance imaging (MRI) is not used in the acute setting, because it is a longer study and requires screening. Furthermore, conventional MRI machines are not accessible in many low-income countries. However, MRI is more able than CT to identify different types of hemorrhage and age the hemorrhage and can also identify acute ischemia. Newer
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Mashup Score: 12Article Commentary: “Early Intubation in Endovascular Therapy for Basilar Artery Occlusion” - 2 month(s) ago
The research available to guide posterior circulation large vessel occlusion management is limited. With posterior circulation strokes accounting for approximately 10% of ischemic strokes, trials to guide management are limited by sample size and overall poor prognosis. Many factors may influence endovascular therapy (EVT) outcomes in this unique stroke population, including the optimal anesthetic approach in acute management. Posterior circulation EVT historically had mixed results in outcomes when
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Mashup Score: 42Time is Brain With Tenecteplase, Too - 2 month(s) ago
Tenecteplase (TNK) is rapidly replacing (alteplase) tPA in hospitals around the world after multiple phase III trials found it to be noninferior to tPA for acute thrombolysis. It is well-described that longer time to treatment with tPA is associated with worse outcomes. Pharmacokinetic differences between TNK and tPA, along with recent trial data suggesting potentially higher early recanalization rates with TNK, raise the question of whether the same time to treatment effect is seen with TNK. In this
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Mashup Score: 10To Bypass or Not to Bypass: Triage for Suspected LVO Stroke - 2 month(s) ago
Debate continues regarding the optimal prehospital transport strategy in patients with suspected acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Behrndtz et al. present results from the TRIAGE-STROKE trial that investigated the effects of direct transport to a comprehensive stroke center (CSC) by bypassing the closest primary stroke center (PSC) on functional outcomes for patients with suspected LVO AIS eligible for intravenous thrombolysis (IVT). This was a multicenter, randomized,
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To Bypass or Not to Bypass: Triage for Suspected LVO Stroke https://t.co/69141No73V In this #BloggingStroke post, @wechsler_paul discusses #Stroke article "Transport Strategy in Patients With Suspected Acute Large Vessel Occlusion Stroke" by @BehrndtzAnne et al. @clauszsimonsen https://t.co/bwyuBjKZsp
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Mashup Score: 19Could Robot-Assisted Transcranial Doppler Replace Transthoracic Echocardiography as Screening for Right to Left Shunt After Cryptogenic Stroke? - 2 month(s) ago
Secondary stroke prevention is often directly tied to the presumed etiology. Given that 45% of non-lacunar ischemic strokes are classified as cryptogenic, there is still a strong need for better screening and diagnostic tools. 1 Finding a right to left shunt (RLS) due to a patent foramen ovale (PFO) could potentially lead to surgical closure, but most stroke patients only receive screening with transthoracic echocardiography (TTE), which has poor sensitivity compar ed to the nonsurgical gold standard,
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Mashup Score: 79
Cervical artery dissection is an uncommon stroke etiology and mostly affects a younger patient population. The treatment of cervical artery dissection varies across different practices and is based on the treating clinician’s experience. Since the mechanism of stroke is deemed to be artery-to-artery emboli, treating it with antithrombotic is an important decision to make. The TREAT-CAD trial concluded non-inferiority of aspirin compared to vitamin K antagonist (VKA) while reporting less ischemic events
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Mashup Score: 11
Qinglan “Priscilla” Ding, MBBS, AGNP, PhD @QDing3 The relationship between psychological stress and its role in acute stroke has long been a subject of discussion. But what about lifetime stress? Does it have any bearing on how one recovers after suffering a stroke? This is precisely what Holman et al. delved into in their recent study. The study utilized data from the multicenter longitudinal STRONG (Stroke, Stress, Rehabilitation, and Genetics) study, which was developed to help understand genetic
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Mashup Score: 1
In the first 72 hours after intracerebral hemorrhage (ICH), secondary injury occurs through several pathways, including cytotoxicity and generation of reactive oxygen species. A major component of the secondary injury pathway is free iron: Heme is released from lysed red blood cells, which is then broken down into iron, carbon monoxide, and biliverdin. Iron catalyzes the formation of free radicals and reactive oxygen species, which, in turn, can cause cell death. Intracellular iron regulation may,
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Mashup Score: 11Article Commentary: “Functional Lesion Network Mapping of Sensory Deficits After Ischemic Stroke” - 3 month(s) ago
The somatosensory system is often affected after an acute ischemic stroke. Schlemm et al. performed an indirect lesion network mapping of somatosensory deficits in patients with an acute ischemic stroke to characterize and identify functional hubs of sensory processing. A retrospective analysis of clinical and imaging data from a prospective observational cohort study, TOPOS (Topological and Clinical Prospective Study About Somatosensation in Stroke), was performed. Patients with a first-ever acute
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New Horizons in Poststroke Hyperglycemia Management: The Promise of Exenatide https://t.co/9V2ertRDGp In this #BloggingStroke post, @QDing3 discusses #Stroke article "Management of Poststroke Hyperglycemia: Results of the TEXAIS Randomized Clinical Trial" by Bladin et al. https://t.co/TWCEXx8GYB