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Mashup Score: 1
The visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. We performed spatial transcriptomic profiling of over 100,000 cells from the mouse retia, uncovering the spatial distribution of all major retina cell types with over 100 cell subtypes. Our data revealed that the retina is organized in a laminar structure at the major cell…
Source: bioRxivCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 4Hippocampal Place-like Signal in Latent Social Space - 2 year(s) ago
During navigation, the hippocampus represents physical places like coordinates on a map; similar location-like signals have been seen in sensory and concept spaces. It is unclear just how general this hippocampal place code is, however: does it map places in wholly non-perceivable spaces, without locations being instructed or reinforced and during navigation-like behavior? To search for such a…
Source: bioRxivCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 3
The posterior parietal cortex (PPC) exhibits choice-selective activity during perceptual decision-making tasks. However, it is not known how this selective activity arises from the underlying synaptic connectivity. Here, we combined virtual reality behavior, two-photon calcium imaging, high throughput electron microscopy, and circuit modeling to analyze how synaptic connectivity between neurons…
Source: bioRxivCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 1Neural heterogeneity promotes robust learning - 3 year(s) ago
The brain has a hugely diverse, heterogeneous structure. By contrast, many functional neural models are homogeneous. We compared the performance of spiking neural networks trained to carry out difficult tasks, with varying degrees of heterogeneity. Introducing heterogeneity in membrane and synapse time constants substantially improved task performance, and made learning more stable and robust…
Source: bioRxivCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 2
Sensory systems constantly compare external sensory information with internally generated predictions. While neural hallmarks of prediction errors have been found throughout the brain, the circuit-level mechanisms that underlie their computation are still largely unknown. Here, we show that a well-orchestrated interplay of three interneuron types shapes the development and refinement of negative…
Source: bioRxivCategories: Future of MedicineTweet
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Mashup Score: 5
A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain areas receiving known sensory inputs. This strategy, as demonstrated…
Source: bioRxivCategories: Future of MedicineTweet
RT @biorxiv_neursci: Spatial organization of the mouse retina at single cell resolution https://t.co/kIMEe2z70S #biorxiv_neursci