Blurring Boundaries in Biophysics: A recent feature in the Biophysical Journal highlights the transformative potential of exascale supercomputers. Spearheaded by experts from Auburn University, the article highlights how high-performance computing is revolutionizing biophysical research. By harnessing the immense power of these revolutionary machines, scientists can now simulate complex biological processes, challenge established assumptions, and even design novel molecular structures. As the integration of computational and experimental biophysics accelerates, we stand on the verge of a new era of unparalleled discoveries that could profoundly change our perception of biology.