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Mashup Score: 0Slit2 Inhibits Breast Cancer Metastasis by Activating M1-Like Phagocytic and Antifibrotic Macrophages - 3 year(s) ago
Tumor-associated macrophages (TAM) are heterogeneous in nature and comprise antitumor M1-like (M1-TAM) or pro-tumor M2-like (M2-TAM) TAMs. M2-TAMs are a major component of stroma in breast tumors and enhance metastasis by reducing their phagocytic ability and increasing tumor fibrosis. However, the molecular mechanisms that regulate phenotypic plasticity of TAMs are not well known. Here we report…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 6Slit2 inhibits breast cancer metastasis by activating M1-like phagocytic and anti-fibrotic macrophages - 3 year(s) ago
Tumor-associated macrophages (TAM) are heterogeneous in nature and comprise anti-tumor M1-like (M1-TAMs) or pro-tumor M2-like (M2-TAMs) TAMs. M2-TAMs are a major component of stroma in breast tumors and enhance metastasis by reducing their phagocytic ability and increasing tumor fibrosis. However, the molecular mechanisms that regulate phenotypic plasticity of TAMs are not well known. Here we…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Slit2 inhibits #BreastCancer #metastasis by enhancing #AntiTumorImmunity through activation of M1-like tumor associated macrophage phagocytic activity against tumor cells and diminishing fibrosis. https://t.co/xI7bA1dLHl https://t.co/Po5vcaFzZA
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Mashup Score: 32ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer - 3 year(s) ago
Wong and colleagues show that LKB1-deficient lung tumors are sensitive to autophagy inhibition, which can restore impaired antigen presentation and antitumor immune responses, and propose dual targeting of ULK1 and PD-1 for these tumors.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
⭐️ONLINE NOW @NatureCancer: "ULK1 inhibition overcomes compromised #AntigenPresentation and restores #AntitumorImmunity in LKB1-mutant lung cancer", a fantastic study by Kwok-Kin Wong and Co Find it here https://t.co/LzGUVybkHm https://t.co/kVNgkWZQyP #Immunotherapy #LungCancer https://t.co/31FejHO6Hd
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Mashup Score: 6Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity - 3 year(s) ago
Alonso and colleagues develop immune-stimulating antibody conjugates capable of specific delivery of TLR7/8 agonists to tumors, which induces durable antitumor immunity.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
ONLINE NOW @NatureCancer: Immune-stimulating antibody conjugates elicit robust myeloid activation and durable #AntitumorImmunity -by Alonso @ShelleyAckPhD Find it at: https://t.co/g6al70zEUz https://t.co/nyXjbwWnZy NVs by @EricVivier1 & @demariaolivier https://t.co/l7Brze9mqg https://t.co/JnHNU9h9tJ
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Slit2 inhibits #BreastCancer #metastasis by enhancing #AntiTumorImmunity through activation of M1-like tumor associated macrophage phagocytic activity against tumor cells and diminishing #fibrosis https://t.co/CTkub1Gngl https://t.co/HkVSWjg8uc