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    These 2 randomized clinical trials compare the efficacy and safety of renin-angiotensin system (RAS) modulation using 2 investigational RAS agents, TXA-127 vs placebo and TRV-027 vs placebo, in adults hospitalized with severe COVID-19.

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    • #Renin-Angiotensin System Modulation With #Synthetic #Angiotensin (1-7) and Angiotensin II Type 1 #Receptor–Biased Ligand in Adults With #COVID19 https://t.co/vX87EOeYtD https://t.co/TCcIFgKhJZ

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    The renin-angiotensin-aldosterone system (RAAS), whose major vasopressor effector is angiotensin II (ATII), has multiple activities and regulates sodium-water homeostasis and fluid and blood pressure homeostasis. RAAS plays a crucial role in cardiocirculatory shock because it counteracts hypotension and hypovolemia by activating different physiologic responses. Based on the encouraging results of…

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    • The use of #angiotensin II in patients with #COVID19 showed promising results because its administration was associated with the achievement and maintenance of target mean arterial pressure, increased PaO2/FIO2 ratio, and decreased FIO2. https://t.co/ThYWG4IqUp https://t.co/OY4IvtG6pO

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    Up to one-third of all patients admitted to intensive care units carry a diagnosis of shock. The use of angiotensin II is becoming widespread in all forms of shock, including cardiogenic, after the U.S. Food and Drug Administration’s (FDA’s) initial approval for vasoplegic shock in 2017. Here, the authors review the literature on angiotensin II’s mechanism of action, benefits, and future…

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    • ✅1/3 of all patients admitted to ICU carry a diagnosis of shock. The use of angiotensin II is becoming widespread in all forms of #shock. ✅Reviewed the literature on #angiotensin II's mechanism of action, benefits, and future therapeutic opportunities. https://t.co/uG9YDTBhb4 https://t.co/q34GnkWwfZ

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    Wolters Kluwer Health - 3 year(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable…

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    • Check out another article from the #neuroimmune interactions special issue: #Angiotensin receptors and #neuropathicpain. @AndrewShep82 https://t.co/Szj0uOcLMU #PAINReports https://t.co/nriEuvYUn1