• Mashup Score: 2

    New data show TDP-43 levels in the brain start to decline almost 20 years before death in Alzheimer’s disease and are linked to the rate of hippocampal atrophy, independently of other biomarkers.

    Tweet Tweets with this article
    • Brain levels of TDP-43, a key factor in neurodegeneration that occurs with #Alzheimers disease, declines nearly 2 decades prior to the end of life. https://t.co/AKvAKasShM #ANA2020 https://t.co/sZ3RDKsfvC

  • Mashup Score: 7

    Despite failed primary cognitive outcomes, secondary measures from the DIAN-TU trial show significant effects on amyloid, other biomarkers; dose escalation may be key.

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    • New data from the phase 2/3 DIAN-TU trial shows notable improvements in key Alzheimer's biomarkers with gantenerumab, despite trial failure to meet its primary endpoint of slowing cognitive decline. https://t.co/Ce0X1BHvh9 #ANA2020

  • Mashup Score: 1

    Despite failed primary cognitive outcomes, secondary measures from the DIAN-TU trial show significant effects on amyloid, other biomarkers; dose escalation may be key.

    Tweet Tweets with this article
    • New data from the phase 2/3 DIAN-TU trial shows notable improvements in key #Alzheimers biomarkers with gantenerumab, despite trial failure to meet its primary endpoint of slowing cognitive decline. https://t.co/sJ5k6GxDCy #ANA2020

  • Mashup Score: 1

    Despite failed primary cognitive outcomes, secondary measures from the DIAN-TU trial show significant effects on amyloid, other biomarkers; dose escalation may be key.

    Tweet Tweets with this article
    • New data from phase 2/3 DIAN-TU trial shows notable improvements in key Alzheimer's biomarkers with gantenerumab, despite trial failure to meet its primary endpoint of slowing cognitive decline. https://t.co/Ya5xXBnTEb #ANA2020