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Mashup Score: 26Early Recanalization Among Patients Undergoing Bridging Therapy With Tenecteplase or Alteplase - 8 month(s) ago
BACKGROUND: Intravenous thrombolysis (IVT) with alteplase or tenecteplase before mechanical thrombectomy is the recommended treatment for large-vessel occlusion acute ischemic stroke. There are diver
Source: www.ahajournals.orgCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
In a post hoc analysis, researchers assessed the health-related quality of life of patients who received alteplase after an acute ischemic stroke.
Source: Neurology AdvisorCategories: Latest Headlines, NeurologyTweet-
Patient health-related quality of life may benefit from intravenous #alteplase after an acute ischemic #stroke. #NeuroTwitter https://t.co/oVCxYGvUz8
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Mashup Score: 3Alteplase for Stroke With Unknown Onset Time in Chronic Kidney Disease: A Pooled Analysis of Individual Participant Data - 1 year(s) ago
Background: Although chronic kidney disease (CKD) is associated with worse stroke outcomes, data regarding the influence of CKD on intravenous thrombolysis outcomes are scarce. We sought to assess th
Source: StrokeCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#STROKE #ChronicKidneyDisease did not modify the benefit seen with IV #Alteplase in stroke patients with unknown onset time: #EOS trial https://t.co/KF8VsiBi9C @mkaori0612 @Braindoc_MGH @warach_steven @sohei_y @GeoffreyDonnan https://t.co/mLisn2QOz4
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Mashup Score: 2Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice - 2 year(s) ago
This cohort study investigates the outcomes of combination endovascular thrombectomy with alteplase compared with endovascular thrombectomy alone for the treatment of patients with acute ischemic stroke attributable to large vessel occlusion.
Source: jamanetwork.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Combination IV thrombolysis + Thrombectomy in Practice: Outcomes @JAMANeuro #thrombectomy #alteplase https://t.co/sUQ0mZUExA
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Mashup Score: 1Alteplase after thrombectomy improves neurological outcomes in acute ischemic stroke - 2 year(s) ago
Intra-arterial alteplase after successful reperfusion with mechanical thrombectomy for large vessel occlusion acute ischemic stroke conferred better neurological outcomes compared with placebo, a speaker reported. Despite the early termination of the trial, the positive results of the CHOICE trial presented at the International Stroke Conference and published in JAMA indicated that intra-arterial
Source: www.healio.comCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Intra-arterial #alteplase after reperfusion with mechanical thrombectomy for LVO acute ischemic stroke conferred better neurological outcomes vs placebo @angelchamorro1 @hospitalclinic #ISC2022 @StrokeAHA_ASA @AHAMeetings @healioneurology #CardioTwitter https://t.co/ahwzFt5Yn7
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Mashup Score: 6Rebellion21: Alteplase for Stroke of Unknown Time of Onset - REBEL EM - Emergency Medicine Blog - 3 year(s) ago
In this 9 minute video from day 2 of Rebellion in EM 2021, I go over the evidence for advanced imaging use in acute ischemic stroke of unknown time of onset to help guide treatment with intravenous alteplase.
Categories: Healthcare Professionals, Latest HeadlinesTweet-
RT @srrezaie: Rebellion21: Alteplase for Stroke of Unknown Time of Onset? https://t.co/sX552lDRBs #FOAMed #Rebellion21 #Stroke #alteplase…
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Mashup Score: 11Switching to Tenecteplase for Stroke Thrombolysis: Real-World Experience and Outcomes in a Regional Stroke Network - 3 year(s) ago
Background and Purpose: Due to practical advantages, increasing trial safety data, recent Australian Guideline endorsement and local population needs we switched to tenecteplase for stroke thrombolys
Source: StrokeCategories: Cardiology News and Journals, Latest HeadlinesTweet-
#STROKE #ESOC2021 Real-world experience after #Alteplase to #Tenecteplase switch implementation in New Zealand showed #Tenecteplase is associated with better functional outcomes (mRS 0-2 OR=2.2) and shorter door-to-needle time @Anna_Ranta https://t.co/4oXIvdHq7x https://t.co/I0xwjEFgBR
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Mashup Score: 5
Background Intravenous alteplase improves outcome after acute ischemic stroke without a benefit in 90‐day mortality. There are limited data on whether alteplase is associated with reduced mortality…
Categories: Latest Headlines, NeurologyTweet-
#Alteplase associated w ⬇️ mortality in patients with ischemic #stroke & #AF not undergoing thrombectomy. Thankful for another IAC group collaboration! @eva_mistry @brianmacgrory @ImanMoeiniMD @Teddyyhwu @neurogiles @AmreNouh @daniyal_asad @StrokeAHA_ASA https://t.co/BJ1Y1jBtVY
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Mashup Score: 6Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke - 3 year(s) ago
The drug nerinetide exerts neuroprotective effects in stroke by interfering with the postsynaptic density protein PSD-95. However, in patients, nerinetide lost the therapeutic effects when administered with (or after) the tissue plasminogen activator alteplase. Here, Mayor-Nunez et al. investigated the interaction between nerinetide and alteplase in rodents and showed that plasmin, activated by…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet-
Why does #nerinetide fail to protect the brain after #stroke alongside #alteplase? A new @ScienceTM study now might have the answer, and shows separating doses or using a peptide derivative of nerinetide restores efficacy in rat models. ($) https://t.co/OGiu9Ij9fG https://t.co/IK7Z5YkCSq
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Mashup Score: 20Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke - 3 year(s) ago
The drug nerinetide exerts neuroprotective effects in stroke by interfering with the postsynaptic density protein PSD-95. However, in patients, nerinetide lost the therapeutic effects when administered with (or after) the tissue plasminogen activator alteplase. Here, Mayor-Nunez et al. investigated the interaction between nerinetide and alteplase in rodents and showed that plasmin, activated by…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet-
Why does #nerinetide fail to protect the brain after #stroke alongside #alteplase? A new @ScienceTM study now might have the answer, and shows separating doses or using a peptide derivative of nerinetide restores efficacy in rat models. ($) https://t.co/OGiu9Ij9fG https://t.co/T7EosUHJXc
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#STROKE Intravenous #alteplase and #tenecteplase achieved early recanalization in one-fifth of LVO patients. Compared to #alteplase, #tenecteplase was associated with 2-fold higher likelihood of early recanalization in larger thrombi. #AHAJournals https://t.co/9tzxB4Wdn1 @jildazz https://t.co/Q87Ih0UUU8