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Mashup Score: 24
BACKGROUND: Despite over a century of clinical electrocardiographic studies showing that females exhibit a faster resting heart rate (HR), the mechanisms underlying sex differences in HR remain unresolved. Moreover, inappropriate sinus tachycardia primarily affects females, whereas males are at a higher risk for conduction block and atrial fibrillation. We hypothesized that the sexual dimorphism of genes responsible for sinoatrial node (SAN) pacemaking and signaling pathways may contribute to the sex differences in HR and susceptibility to arrhythmias. METHODS: Human SAN central pacemaker and right atrial tissue were isolated from nondiseased ex vivo donor hearts. Gene expressions were quantified and validated using the transcriptomic panel and quantitative polymerase chain reaction. Gene set enrichment analysis, Ingenuity Pathway Analysis, and human-specific SAN models were utilized to define regulatory mechanisms and functional impacts of sex-biased gene transcription. RESULTS: We id
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Mashup Score: 62
View all available purchase options and get full access to this article. Duytschaever M, De Potter T, Grimaldi M, Anic A, Vijgen J, Neuzil P, Van Herendael H, Verma A, Skanes A, Scherr D, et al; inspIRE Trial Investigators. Paroxysmal atrial fibrillation ablation using a novel variable-loop biphasic pulsed field ablation catheter integrated with a 3-dimensional mapping system: 1-year outcomes of the multicenter inspIRE study. Circ Arrhythm Electrophysiol. 2023;16:e011780. doi: 10.1161/CIRCEP.122.011780
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
The incidence and size of silent strokes after pulsed field ablation differ between the circular shaped ablation catheters @TAMA07120380 @TakuroNishimu @iwanari65284818 #AHAJournals #Epeeps https://t.co/tKpCtdSNtZ https://t.co/V01YtKVOch
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Mashup Score: 21
BACKGROUND: Despite over a century of clinical electrocardiographic studies showing that females exhibit a faster resting heart rate (HR), the mechanisms underlying sex differences in HR remain unresolved. Moreover, inappropriate sinus tachycardia primarily affects females, whereas males are at a higher risk for conduction block and atrial fibrillation. We hypothesized that the sexual dimorphism of genes responsible for sinoatrial node (SAN) pacemaking and signaling pathways may contribute to the sex differences in HR and susceptibility to arrhythmias. METHODS: Human SAN central pacemaker and right atrial tissue were isolated from nondiseased ex vivo donor hearts. Gene expressions were quantified and validated using the transcriptomic panel and quantitative polymerase chain reaction. Gene set enrichment analysis, Ingenuity Pathway Analysis, and human-specific SAN models were utilized to define regulatory mechanisms and functional impacts of sex-biased gene transcription. RESULTS: We id
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
Why faster heart rhythm in women? Sex-biased SAN genes link TBX3/HCN1 to female tachycardia, while inflammation genes promote male bradycardia & AF risk @jichaozhao #AHAJournals #Epeeps https://t.co/tyWKFhBMY3 https://t.co/hhcfKVv3y6
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Mashup Score: 9
View all available purchase options and get full access to this article. Ono K, Iwasaki YK, Akao M, Ikeda T, Ishii K, Inden Y, Kusano K, Kobayashi Y, Koretsune Y, Sasano T, et al; Japanese Circulation Society and Japanese Heart Rhythm Society Joint Working Group. JCS/JHRS 2020 guideline on pharmacotherapy of cardiac arrhythmias. Circ J. 2022;86:1790–1924. doi: 10.1253/circj.CJ-20-1212 Takahashi Y, Yamaguchi T, Otsubo T, Nakashima K, Shinzato K, Osako R, Shichida S, Kawano Y, Fukui A, Kawaguchi A, et al.
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Progression of atrial cardiomyopathy assessed by left atrial low-voltage areas predicts stroke after initial atrial fibrillation ablation #AHAJournals #Epeeps https://t.co/NbU0OyYp1A https://t.co/r7qWVtLgUS
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Mashup Score: 3Sudden Cardiac Death in Childhood: Peaks in Teenagers | Circulation: Arrhythmia and Electrophysiology - 3 month(s) ago
Request permissions for this article. CRY Centre for Cardiovascular Pathology, Cardiovascular Clinical Academic Group and Cardiology Research Section, Cardiovascular and Genomics Research Institute, St George’s University of London, United Kingdom. St George’s University Hospitals NHS Foundation Trust, London, United Kingdom. CRY Centre for Cardiovascular Pathology, Cardiovascular Clinical Academic Group and Cardiology Research Section, Cardiovascular and Genomics Research Institute, St George’s University
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Sudden cardiac death in children peaks in teens caused by heritable cardiomyopathy and SADS. Cardiological relative screening should be prior to 13. #AHAJournals #EPeeps https://t.co/yjSi1FGGDr
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Mashup Score: 50
BACKGROUND: Over the past decades, hypertrophic cardiomyopathy has become a contemporary treatable disease. However, limited data exist on the global trends of implantable cardioverter defibrillator (ICD) utilization and its impact on mortality/morbidity burden reduction. METHODS: Electronic databases were systematically searched up to March 2024 for studies reporting on ICD utilization rates in hypertrophic cardiomyopathy. A random effects model was used to pool study estimates across time-era, geographic region, and age group. Primary outcome was global trends in ICD utilization. Secondary outcomes included trends of sudden cardiac death, appropriate/inappropriate shocks, and ICD-related complications. RESULTS: In total, 234 studies (N=92 500, 514 748 patient-years) met inclusion criteria. Mean age was 46.2 (12.4) years and 37.49% were women. A total of 12 139 patients (16.43%) received an ICD over 429 766 person-years of follow-up, with an ICD implantation rate of 2.79%/y ([95% CI,
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Over 4 decades, ICD utilization rates in HCM have increased by 4 fold worldwide, in parallel with a 3 fold reduction in SCD rates. Geographical disparities in ICD utilization were evident #AHAJournals #EPeeps @AbdelfattahMD @ahmed_sayed_98 https://t.co/vJq0g1iLPE https://t.co/1YpiqyM5uU
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Mashup Score: 58
BACKGROUND: Current clinical guidelines emphasize the significance of rhythm control with catheter ablation but lack guidance on the timing of atrial fibrillation (AF) ablation relative to the diagnosis time. We aim to investigate the latest evidence on the impact of diagnosis to ablation time (DAT) on clinical outcomes after AF ablation. METHODS: We searched PubMed, Web of Science, Scopus, Embase, and Cochrane Central Register of Controlled Trials through August 2024. Pairwise, prognostic, and reconstructed time-to-event data meta-analyses were conducted using R V. 4.3.1. Our primary end point was time to first AF recurrence, with secondary end points of all-cause mortality, tamponade, stroke, and heart failure. RESULTS: Our cohort included 23 studies with 43 711 patients. Shorter DAT was significantly associated with reduced AF recurrence across both paroxysmal and persistent AF subgroups (P<0.01). There was a significant decrease in benefit for paroxysmal AF over time and a slight d
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Early ablation after initial AF diagnosis is associated with lower AF recurrence (esp. paroxysmal AF), lower mortality, and a trend for lower strokes #AHAJournals #EPeeps https://t.co/kDskqHraFv
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Mashup Score: 25
BACKGROUND: QT correction (QTc) formulae are widely used in clinical and research settings but often underperform, possibly due to demographic influences on the QT–heart rate (HR) relationship. To address this limitation, we developed an adaptive QTc (QTcAd) formula, which adjusts for demographic factors like age, and compared its efficacy to other standard formulae. METHODS: The QTcAd formula was tested across diverse age groups with different HR in both humans and guinea pigs. Using retrospective ECG data from 1819 pediatric patients at Children’s National Hospital and 2400 subjects from the Pediatric Heart Network database, alongside in vivo (n=55) and ex vivo (n=66) guinea pig ECG recordings, we evaluated the formula’s effectiveness. Linear regression fit parameters of QTc-HR (slope and R²) were utilized for performance assessment. To evaluate the accuracy of the predicted QTc, we acquired epicardial electrical and optical voltage data from Langendorff-perfused guinea pig hearts. R
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Novel QTc (adaptive) formula adjusts for demographics using human and guinea pig data. This formula outperformed standard QT correction formulae in both accuracy and efficacy #AHAJournals #EPeeps https://t.co/3sVZP12Yt6 https://t.co/JdZkptkv9n
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Mashup Score: 20Complete Left Bundle Branch Block With V5/V6: RS/Rs/rS Pattern and Long-Term Outcomes | Circulation: Arrhythmia and Electrophysiology - 3 month(s) ago
View all available purchase options and get full access to this article. Request permissions for this article. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Xi’an Medical University, China (S.H.). Xinjiang Key Laboratory of Medical Animal Model Research, Clinical Medical Research Inst of Xinjiang Medical University, Ürümqi, China (S.H.). Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital
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Complete left bundle branch block with V5/V6: RS/Rs/rS (+) pattern was associated with poor long-term outcomes including mortality and hospitalization for heart failure #AHAJournals #Epeeps https://t.co/JoG2v9FArG
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Mashup Score: 28
BACKGROUND: Pulmonary vein isolation (PVI) alone is less effective in patients with persistent atrial fibrillation (AF) compared with those with paroxysmal AF. We investigate whether additional linear ablation from the superior vena cava to the right atrial septum and cavotricuspid isthmus ablation improves the rhythm outcome of patients with persistent AF undergoing cryoballoon PVI (Cryo-PVI). METHODS: In this investigator-initiated, multicenter, randomized clinical trial, 289 patients with persistent AF refractory to antiarrhythmic drug therapy were randomized 1:1 to either Cryo-PVI with additional right atrium (RA) linear ablation or Cryo-PVI alone. The primary end point was any documented atrial arrhythmia lasting ≥30 seconds after a 3-month blanking period after ablation. The secondary end points were atrial arrhythmia recurrence or antiarrhythmic drug use after a 3-month blanking period, complications, and total procedure time. RESULTS: During the median follow-up of 24 months (m
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Adding right atrial ablation targeting the third fat pad and cavotricuspid isthmus to cryoballoon PV isolation reduces atrial arrhythmia recurrence by 34% in persistent AF #AHAJournals #Epeeps https://t.co/3V4SUZFZ0z https://t.co/0wE76Ec2uz
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Why faster heart rhythm in women? Sex-biased SAN genes link TBX3/HCN1 to female tachycardia, while inflammation genes promote male bradycardia & AF risk @jichaozhao #AHAJournals #Epeeps https://t.co/tyWKFhBMY3 https://t.co/hhcfKVv3y6