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Mashup Score: 2Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo - 2 year(s) ago
Flavivirus vaccine development is complicated by the risk of antibody-dependent enhancement (ADE), which is mediated by non-neutralizing antibodies. Georgiev et al. use structure-guided phage display to mask epitopes in the ZIKV EDIII subunit that are targeted by non-neutralizing antibodies. The resurfaced rsZDIII immunogens elicit protective but immune-focused responses in mice.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 5New interpretable machine-learning method for single-cell data reveals correlates of clinical response to cancer immunotherapy - 2 year(s) ago
A novel interpretable machine-learning method is developed and applied to discover and visualize candidate biomarkers of response to immunotherapy in single-cell data from a Merkel cell carcinoma clinical trial. We provide demonstrations of how to validate findings on independent cytometry datasets, simulation and benchmark studies comparing our method with existing approaches, and illustrations…
Source: PatternsCategories: General Medicine News, Latest HeadlinesTweet-
"New interpretable machine-learning method for single-cell data reveals correlates of clinical response to cancer immunotherapy" - read the full article by @raphg in @Patterns_CP #AAI2022 https://t.co/VoE4BkNFIn
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Mashup Score: 2An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity - 2 year(s) ago
Zhang et al. use a proximity labeling technology to identify human proximal proteins of SARS-CoV-2. They show that SARS-CoV-2 manipulates key cellular processes in antiviral and immune responses. They provide a resource for elucidating the mechanisms of SARS-CoV-2 infection and developing drugs for COVID-19 treatment.
Source: Cell Chemical BiologyCategories: General Medicine News, Latest HeadlinesTweet-
An antibody-based proximity labelling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity - check out the full article by Jian Wang of Beijing Institute of Lifeomics, CAS & others in @CellChemBiol #AAI2022 https://t.co/Di7s9qTnmq
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Mashup Score: 2SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals - 2 year(s) ago
Richardson et al. show that SARS-CoV-2 Omicron infection in unvaccinated individuals triggers potent antibody responses; however, cross-reactivity against variants of concern is poor. In contrast, Omicron BA.1 breakthrough infection in vaccinated individuals elicits high titer cross-reactive antibodies. Omicron-based vaccines are thus unlikely to be superior immunogens in SARS-COV-2-naive…
Source: Cell Host & MicrobeCategories: General Medicine News, Latest HeadlinesTweet-
SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals - full article by Penny L. Moore @nicd_sa in @cellhostmicrobe #AAI2022 https://t.co/lhWYT7fATB
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Mashup Score: 1Effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes - 2 year(s) ago
Allergic contact dermatitis, Atopic dermatitis, Interleukin-22, Dipeptide, L-Glu-L-Trp.
Source: HeliyonCategories: General Medicine News, Latest HeadlinesTweet-
Discover the effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes. Out now in @HeliyonJournal #AAI2022 https://t.co/rAx4tUxa7s
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Mashup Score: 0Editors' Choice Anniversary Collection - 2 year(s) ago
Immunotherapy Advances is proud to mark its first anniversary. Join us in celebrating this milestone by enjoying a collection of articles hand-picked by our Edi
Source: Oxford AcademicCategories: General Medicine News, Latest HeadlinesTweet-
OUP and @britsocimm invite all #AAI2022 attendees to enjoy the Editors’ Choice Anniversary Collection from @IMTadvances, with impactful immunotherapy articles hand-selected by Editor-in-Chief @tim_tje. Start reading now. https://t.co/XvY6Z9lDYv https://t.co/r3oxPJ4yYD
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Mashup Score: 5
Through comprehensive cellular and molecular analysis of virus-specific T cells in circulation and across multiple lymphoid and mucosal tissues, Poon et al. elucidate how maintenance and function of the human anti-viral immune response against ubiquitous viruses influenza and cytomegalovirus are shaped by virus, tissue, age, and sex.
Source: Cell ReportsCategories: General Medicine News, Latest HeadlinesTweet-
Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex - read the full article by @DonnaFarber3 & colleagues @CellReports #AAI2022 https://t.co/pbPVGSRnSp
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Mashup Score: 5Primary B cell engineering for therapeutic research - 2 year(s) ago
Peripheral blood mononuclear cells (PBMCs) are harvested from patients and purified for CD19+ B cells. B cells can also be derived from iPSCs. Purified B cells are activated/expanded in culture to prime them for genome engineering. Lentivirus, transposons, and CRISPR/Cas9 together with recombinant adeno-associated viral vector (rAAV) carrying DNA donor template for homology directed repair (HDR)…
Source: Trends in Molecular MedicineCategories: General Medicine News, Latest HeadlinesTweet-
Check out this strategy of the month: Primary B cell engineering for therapeutic research, by Branden S. Moriarity @mw_umn_labs & others@TrendsMolecMed #AAI2022 https://t.co/7yumAMbJHr
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Mashup Score: 1
Anaphylaxis; Anesthesia; Hypersensitivity reactions; Intraoperative; Perioperative period.
Source: HeliyonCategories: General Medicine News, Latest HeadlinesTweet-
Check out this case report on the successful identification of culprit drugs of perioperative anaphylaxis by Orathai Theankeaw @MahidolU et al.@HeliyonJournal #AAI2022 https://t.co/DFmraMNcXx
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Mashup Score: 2Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection - 2 year(s) ago
Interactions with the microbiota alter host defense against pathogens. Woo et al. report that commensal bacteria, including segmented filamentous bacteria, can express aldehyde dehydrogenase (aldh) enzymes, producing retinoic acid in the intestine. Bacterial-derived retinoic acid primes epithelial defense and promotes innate protection against intestinal infection.
Source: Cell Host & MicrobeCategories: General Medicine News, Latest HeadlinesTweet-
Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection Theresa Alenghat @AlenghatLab et al. @cellhostmicrobe #AAI2022 https://t.co/hmnIkDfIFk
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Online now: Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo - read the full article by Jonathan R. Lai @EinsteinMed & colleagues @CellChemBiol #AAI2022 https://t.co/sVJGQn6VVH