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Mashup Score: 90Scripps Research scientists discover chemical probes for previously “undruggable” cancer target - 1 month(s) ago
Structural models predict the small molecule-binding site on FOXA1 is proximal to DNA. Credit: Scripps Research Scientists uncover how small molecules interact with a cancer-related protein called FOXA1 and identify a crucial binding site on its surface. LA JOLLA, CA — Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 69NIH awards two Scripps Research fellows more than $1 million each for their high-risk, high-impact work - 2 month(s) ago
Shannon Miller, PhD (left) and Megan Ken, PhD (right). Credit: Scripps Research Fellows Shannon Miller and Megan Ken have both received NIH Director’s Awards from the NIH Common Fund’s High-Risk, High-Reward Research program. LA JOLLA, CA — In recognition of their innovative research trajectories, the National Institutes of Health (NIH) has granted NIH Director’s Awards to Scripps Research Fellows Shannon Miller, PhD, in the Department of Chemistry, and Megan Ken, MD, PhD, in the Department of Integrative
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Scripps Research Fellows @_ShannonMMiller and @Magnetic_Megan, are awarded $1M+ @NIH grants for innovative gene therapy & RNA research under the #NIHHighRisk, High-Reward program, supporting high-impact projects with breakthrough potential. More: https://t.co/FJanQEdFrr https://t.co/n9HABgg8vU
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Mashup Score: 24Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain - 2 month(s) ago
Stuart Lipton, MD, PhD. Credit: Scripps Research The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer’s disease. LA JOLLA, CA — Stuart Lipton, MD, PhD, professor and Step Family Foundation Endowed Chair, and Tomohiro Nakamura, PhD, Institute Investigator in the Neurodegeneration New Medicines Center and Department of Molecular Medicine at Scripps Research, have been awarded about $5 million from the National Institute on Aging (NIA) to study
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Backed by a $5M grant from the @NIHAging, Prof. Stuart Lipton, Tomohiro Nakamura, PhD and @JohnRYatesIII will examine how air pollution may contribute to Alzheimer’s, a study that could uncover new pathways for treating neurodegeneration. More at: https://t.co/NJyav98L0i https://t.co/F9dt9CiV77
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Mashup Score: 20Scripps Research scientist Ilia Droujinine receives over $3 million to reveal the body’s interorgan networks - 2 month(s) ago
(Left to right) Sourav Ghosh, Lily Wang, Ricard Garcia-Carbonell, Emily Huynh, Assistant Professor Ilia Droujinine (center front), Yifan Wang, Lauren Hoffner, Michael Banki, Laura Long, Rama Aldakhlallah. Credit: Scripps Research. The awards from the NIDDK and the LLHF will let Droujinine uncover how interorgan communication goes awry in metabolic disease and aging, paving the way for new treatments. LA JOLLA, CA — Ilia Droujinine, PhD, assistant professor at the Department of Molecular Medicine at
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Scripps Research assistant professor Ilia Droujinine receives $3.2M from @NIDDKgov & Larry L. Hillblom Foundation to study interorgan networks in metabolic & age-related diseases. @DroujinineLab’s work could reveal new therapies for obesity & #diabetes. https://t.co/ynQJ4z9pmf https://t.co/Bhy6nLB4so
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Mashup Score: 119Eight new faculty join Scripps Research - 2 month(s) ago
The newly appointed faculty are making transformative discoveries in areas ranging across drug discovery, neuroscience, chemistry, immunity and more. LA JOLLA, CA — Scripps Research is welcoming eight new scientists who bring their expertise to advance crucial discoveries in human health. They aim to make significant strides in areas including HIV, cancer, inflammatory bowel disease, autoimmune disorders and much more. “This enormously talented group of scientists brings a diverse array of cutting-edge
Source: www.scripps.eduCategories: General Medicine News, NeurologyTweet-
8 new colleagues are joining the @scrippsresearch faculty! This includes current @HHMINEWS investigators Doro Kern & Darrell Irvine, Meng Zhang from Xiaowei Zhuang's lab, and Ann Kennedy @Antihebbiann in Neuroscience. Exciting times ahead! 🚀 https://t.co/ErVZYnaKEn https://t.co/YhYAXDikid
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Mashup Score: 93Seeing double: Designing drugs that target “twin” cancer proteins - 2 month(s) ago
A drug candidate (pink) found to bind to the pocket between the cancer-related protein CCNE1 (green) and its partner CDK2 (blue) using the new paralog-hopping approach. Credit: Scripps Resear ch Scripps Research scientists used knowledge about a protein to characterize drugs that selectively bind to its “twin,” or paralog. LA JOLLA, CA — Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
A study in @nchembio by Prof. Benjamin Cravatt and @YuanjinZhang1 developed “‘paralog-hopping”’ to target the #cancer protein CCNE1 by pinpointing a druggable site on its twin CCNE2. Targeting cryptic drug-binding pockets could advance cancer therapies. https://t.co/wzNrzr6L1Q https://t.co/DcMZ1taAxu
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Mashup Score: 21Scripps Research on Threads - 2 month(s) ago
August 2024 | 27 min 11 sec Four years after the onset of the COVID-19 pandemic, another virus threatens to reach pandemic potential: the H5N1 bird flu. We sit down with Arnab Chatterjee, vice president of medicinal chemistry at Calibr-Skaggs, who explains the need to invest in the best science to make sure we’ re more prepared than we were for the SARS-CoV-2 outbreak. Chatterjee breaks down how likely it is for H5N1 to become transmitted between humans, and the steps we can take now to better protect
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Can we rewrite the building blocks of life? In our latest Science Changing Life podcast episode, @_ShannonMMiller, PhD, discusses #CRISPR's potential to reverse diseases and the ethics of gene editing. 🧬 🎧 Listen now: https://t.co/O7M7dUHAHR https://t.co/FAkaQWzjou
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Mashup Score: 202
An international collaboration between Scripps Research, University of Arizona, CNRS and others provides additional analysis of how the pandemic began. Press release courtesy of Cell Press, with light edits for stylistic purposes. LA JOLLA, CA — A new international collaborative study from scientists at Scripps Research, the University of Arizona, the French National Centre for Scientific Research (CNRS), and others provides a list of the wildlife species present at the market from which SARS-CoV-2, the
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Genetic evidence from the Huanan Seafood Market strengthens the #COVID19 animal origin hypothesis. Scripps Research, @CNRS and @uarizona identified raccoon dogs and civet cats in stalls with positive samples of #SARSCoV2. More at: https://t.co/OCSXv5VH00 https://t.co/ch0Tu7nryO
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Mashup Score: 19
Examples of the > 100 macrocycles generated in this study. Colored components represent new-to-nature amino acids that were incorporated into either peptide. Credit: Scripps Research The novel method uses sets of four RNA nucleotides — rather than the natural three — to encode new, synthetic building blocks into proteins. LA JOLLA, CA — It’s a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words.
Source: www.scripps.eduCategories: General Medicine News, Future of MedicineTweet-
@AhmedHBadran @scrippsresearch @PrincetonMolBio @yestello .@scrippsresearch scientists expand the genetic alphabet to create new proteins #NBTintheNews https://t.co/zqapNzUkHx https://t.co/agfzjJZNTw
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Mashup Score: 17
Examples of the > 100 macrocycles generated in this study. Colored components represent new-to-nature amino acids that were incorporated into either peptide. Credit: Scripps Research The novel method uses sets of four RNA nucleotides — rather than the natural three — to encode new, synthetic building blocks into proteins. LA JOLLA, CA — It’s a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words.
Source: www.scripps.eduCategories: General Medicine News, Future of MedicineTweet-
@AhmedHBadran @scrippsresearch @PrincetonMolBio @yestello .@scrippsresearch scientists expand the genetic alphabet to create new proteins #NBTintheNews https://t.co/zqapNzUkHx https://t.co/agfzjJZNTw
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New findings in @MolecularCell by Ben Cravatt and @Michael_A_Erb identify a ligandable site on the “undruggable” FOXA1 transcription factor in hormone-driven cancers. Dual ABPP maps FOXA1-small molecule interactions, guiding therapeutic design. More at: https://t.co/1sHz04KtgP https://t.co/QAnTGAwEQC