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Mashup Score: 3The cereblon-AMPK (AMP-activated protein kinase) axis in chondrocytes regulates the pathogenesis of osteoarthritis - 3 month(s) ago
AMP-activated protein kinase (AMPK) dysregulation is implicated in osteoarthritis (OA), but the mechanisms underlying this dysregulation remain unclear. We investigated the role of cereblon, a substrate-recognition protein within the E3-ligase ubiquitin complex, in AMPK dysregulation and OA pathogenesis.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 7
Loading is invariably an important factor of consideration for understanding the causality flow and parallel existence of articular cartilage and subchondral bone changes. The goal of this study was to investigate the patterns of subregional 18NaF-SUV vs. T1p-T2 associations and vertical ground reaction force loading rates; in isolated patellofemoral-joint-osteoarthritis (PFJ-OA) patients.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Association patterns were identified in PFJ-OA subjects between subchondral bone SUV, cartilage, T1p and T2 in trochlear and patellar, medial, and lateral regions and vertical GRF loading rates. @Rupsa_B @sharmilamajumda @PedoiaValentina @richsouza_ucsf 🔗 https://t.co/eia5zx2qUk https://t.co/IzV5H8HSNL
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Mashup Score: 5
To determine if subtypes of cam morphology on anteroposterior radiographs exist using statistical shape modeling (SSM), and to assess their association with incident radiographic hip osteoarthritis (RHOA) within 10 years.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
4⃣ distinct cam morphology subtypes identified in the CHECK study👇 Read more about their r'ship with future hip #osteoarthritis in this large study (10y f/u, n=1002) by Tang et al. @JosRunhaar @RintjeAgricola @ErasmusMC in this month's @OACJournal issue! https://t.co/wShnUrh3eV https://t.co/M6rf8DEmGc
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Mashup Score: 9Frequent use of prescription NSAIDs among people with knee or hip osteoarthritis despite contraindications to or precautions with NSAIDs - 3 month(s) ago
To describe the use of non-steroidal anti-inflammatory drugs (NSAID), opioids, and physiotherapy (PT) among persons with newly diagnosed knee or hip osteoarthritis (OA) with and without NSAID contraindications or precautions.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
In people (n=35173) with newly dx #osteoarthritis: 27% used oral NSAIDs 10% used opioids 57% attended #physiotherapy What about those with contraindications to oral NSAIDs? Read in DEC's @OACJournal from @Tuhina_Neogi @Andre_Dellisola @dr_englund https://t.co/aJ8RJ1ls4z https://t.co/Xe3u7Hyxhw
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Mashup Score: 27
To investigate whether duration of knee symptoms influenced the magnitude of the effect of exercise therapy compared to non-exercise control interventions on pain and physical function in people with knee osteoarthritis (OA).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
🎄 New in this month's @OACJournal 🤔Which subset of knee #osteoarthritis patients would benefit the most from #exercisetherapy? 🤩 Those with shorter symptom duration! 🆓from Middelkoop @dschiphof @JoannaSimkins @KimBennell @HinmanRana @KelliAllenPhD https://t.co/2izwIgK2Bd https://t.co/9NkCMVVM7Q
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Mashup Score: 1The impact of an illness perception conversation on open-label placebo response in knee osteoarthritis: A randomised controlled trial - 3 month(s) ago
To compare the effect of an illness perception conversation (IPC), relative to a research participation conversation (RPC), on 2-week changes in knee pain in patients with knee osteoarthritis.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
NEW in this month's @OACJournal Real all about placebo effects and #illnessperception in this excellent RCT from Odense and @AarhusUni_int Open access from Ginnerup-Nielsen et al @DrRChristensen @AnnaDossing @henriksen_mh @kristensen - https://t.co/RzE620qUmb
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Mashup Score: 19High frequency of BCP, but less CPP crystal-mediated calcification in cartilage and synovial membrane of osteoarthritis patients - 3 month(s) ago
Ectopic articular calcification is a common phenomenon of osteoarthritic joints, and closely related to disease progression. Identification of the involved calcium crystal types represents an important topic in research and clinical practice. Difficulties in accurate detection and crystal type identification have led to inconsistent data on the prevalence and spatial distribution of Basic calcium phosphate (BCP) and calcium pyrophosphate (CPP) deposition.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
The #BasicScience #EditorsChoice for #December is this work by Stücker et al. Read about OA related calcifications here: https://t.co/VpcrqJM0u2 https://t.co/q682GxCLpF
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Mashup Score: 37
To examine the prevalence of preexisting articular bone pathology in patients with hip or knee pain due to osteoarthritis (OA) screened for fasinumab clinical trials.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
This month's Editor's Choice is out! How common is severe bone damage in #osteoarthritis patient presenting to a phase-3 Nerve Growth Factor #NGF inhibitor (fasinumab) clinical trial?🧪 Read for free from DiMartino et al. @Tuhina_Neogi at https://t.co/dtZ5yFLr3J https://t.co/pgr1s2dXGF
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Mashup Score: 12
Patellofemoral osteoarthritis (OA) may be more common in females than males. Reasons for this are not fully understood, but sex differences in patellar morphology may help explain this phenomenon. We quantified differences in patellar morphology between males and females in healthy and patellofemoral OA populations.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Wilson et al. identify sex differences in patella bone shape, and suggest that lateral facet shape may be of interest in future models of OA risk in the patellofemoral joint. Read more 📖 : https://t.co/AmdxN4NLTY. @Lwilso9 @joelynch81 https://t.co/jGZaKOPOdv
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Mashup Score: 3Evaluation of circulating microRNA signature in patients with erosive hand osteoarthritis: The HOAmiR study - 3 month(s) ago
To identify circulating micro-RNAs differentially expressed in patients with erosive hand osteoarthritis (HOA) compared to patients with non-erosive HOA and patients without HOA.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
In this work, Auroux et al. aim to identify circulating micro-RNAs differentially expressed in patients with erosive hand osteoarthritis (HOA) compared to patients with non-erosive HOA and patients without HOA. Read more📑: https://t.co/BWpwN1y5MS https://t.co/Wbys4ttRPh
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This month in #OAC #BasicScience Lee et al. found that the Cereblon-AMPK (AMP-Activated Protein Kinase) Axis in Chondrocytes Regulates Osteoarthritis Read more🔗 : https://t.co/fP4gX0MJZX https://t.co/iHJAtbZlNE