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Mashup Score: 12Early microRNA and metabolite changes after anterior cruciate ligament reconstruction surgery - 1 month(s) ago
Anterior cruciate ligament (ACL) reconstruction after injury does not prevent post-traumatic osteoarthritis (PTOA). Circulating microRNA (miRNA) and metabolite changes emerging shortly after ACL injury and reconstruction remain insufficiently defined, potentially harbouring early cues contributing to PTOA evolution. Moreover, their differential expression between females and males also may influence PTOA’s natural trajectory. This study aims to determine alterations in plasma miRNA and metabolite levels in the early stages following ACL reconstruction and between females and males.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 7The mediation effects of malalignment on the relation of sex to the risk of incidence tibiofemoral osteoarthritis - 2 month(s) ago
To investigate to what extent the higher risk of tibiofemoral radiographic osteoarthritis (TFROA) in females vs. males can be explained by knee malalignment.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
🙋 New @OACJournal Females had a higher risk of developing lateral tibiofemoral radiographic #OA than males But, valgus #malalignment only modestly explained such a difference #sex #gender Xin et al - https://t.co/LiGOYa52Xg https://t.co/enGllad9bf
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Mashup Score: 2DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy - 2 month(s) ago
DNA damage-inducible transcript 3 (DDIT3), as a downstream transcription factor of endoplasmic reticulum stress, is reported to regulate chondrogenic differentiation under physiological and pathological state. However, the specific involvement of DDIT3 in the degradation of condylar cartilage of temporomandibular joint osteoarthritis (TMJOA) is unclarified.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
New Study on TMJOA in @OACJournal Interested in learning about OA in the TMJ? Checkout this awesome work identifying the crucial role of DDIT3-inhibited autophagy in condylar cartilage degradation during the development of TMJOA. Read more: 📑 https://t.co/4iDUUNH7Vh https://t.co/wIp6QGcwfk
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Mashup Score: 11HSP70—A key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli - 2 month(s) ago
During physical activities, chondrocytes experience coupled stimulation of hydrostatic pressure (HP) and a transient increase in temperature (T), with the latter varying within a physiological range from 32.5 °C to 38.7 °C. Previous short-term in vitro studies have demonstrated that the combined hydrostatic pressure-thermal (HP-T) stimuli more significantly enhance chondroinduction and chondroprotection of chondrocytes than isolated applications. Interestingly, this combined benefit is associated with a corresponding increase in HSP70 levels when HP and T are combined.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
New Basic Science #AugustEdition @OACJournal Learn more about the role HSP70 and the combined benefits of hydrostatic and temperature changes in chondrocytes during #PhysicalAcivity. 🔗 https://t.co/Cm8HQcz1nY https://t.co/MH7i5oQ9an
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Mashup Score: 20Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain - 3 month(s) ago
Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
✨ NEW ✨ AUG #EditorsChoice Paper Hand ✋ #OA phenotypes based on a #biopsychosocial approach confirming the symptom-structure discordance of hand OA pain Mulrooney et al @IdaBosHaugen @Tuhina_Neogi @REMEDY_center | @ProfDavidHunter 🔓 Read free @ https://t.co/Yh2LMD3BuF https://t.co/KMxYWiM7Bj
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Mashup Score: 19Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST) - 3 month(s) ago
Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
⚠️ NEW @OACJournal Results from a large trial (n ~1900) exploring the link between osteoarthritic pain & physical activity 🏃 #centralsensitization #stepcount 👏 Led by @Soyoung___Lee @ProfDeepakKumar @bu_movelab @BU_BMC_Rheum Read more @ https://t.co/vJe941D820 👀
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Mashup Score: 3Osteoarthritis Year in Review 2024: Rehabilitation and Outcomes - 3 month(s) ago
This Year in Review presents key highlights from recent research relating to osteoarthritis rehabilitation and its outcomes, defined as any non-pharmacological and non-surgical treatment that aims to improve osteoarthritis symptoms at any joint. Three databases (Medline, Embase, and CINAHLplus) were searched between 1 March 2023 to 12 March 2024. Relevant studies were chosen based on the predefined inclusion/exclusion criteria, perceived clinical importance, quality, controversy in the field, or personal interest, and organised into four overarching themes (with 1-5 sub-themes each).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
RT @LifetimeHip: Osteoarthritis Rehabilitation Year in Review 4 themes: @OACJournal via @Mattjones0203 🧵 https://t.co/tSGUQNqThe https:/…
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Mashup Score: 2Repurposing drugs for the treatment of osteoarthritis - 3 month(s) ago
Currently, no disease-modifying therapies for osteoarthritis (OA) exist, and attempts to identify novel cellular targets have been challenging. Risk factors for OA include advanced age, obesity, and metabolic syndrome. This creates an attractive opportunity to repurpose existing drugs that are used to treat comorbidities commonly encountered in patients with OA, if those drugs possess OA disease modifying properties.
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
Edit: link to paper should be https://t.co/KK0XbCv9HW
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Mashup Score: 14SOARing towards new heights in post-traumatic knee osteoarthritis — New opportunities for prevention - 3 month(s) ago
Ask anyone to paint the picture of a patient with osteoarthritis (OA) and you will likely see an older person looking back at you. While OA is traditionally considered a disease of older people, a distinct form of OA can affect younger adults — post-traumatic OA. We have known for more than two decades that OA affects people aged <40 years at an alarming rate after a traumatic knee injury.1
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
⚠️ NEW @OACJournal #DrugRepurposing Can repurposing existing drugs 💊 for #osteoarthritis treatment improve existing outcomes? #diseasemodification #DMOAD #rheumatology Read more from @mbake013 @WKuswanto @StanfordRheum @StanfordMed 👇 https://t.co/Y6rZwhyVLo https://t.co/yepvkW6tct
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Mashup Score: 20
Assess the efficacy of an 8-week virtual, physiotherapist (PT)-guided knee health program (Stop OsteoARthritis (SOAR)) to improve knee extensor strength in individuals at risk of post-traumatic knee osteoarthritis (PTOA).
Source: www.oarsijournal.comCategories: General Medicine News, RheumatologyTweet-
⚠️ NEW @OACJournal Read about an 8-week virtual, PT-guided knee health program (SOAR) to improve outcomes of post-traumatic knee #OA @JayLos18 @jwhittak_physio @LKTphysio @yegphysio @PhysioKTBroker @LLi_1 @MaxiMiciak @ewa_roos @Arthritis_ARC 👀 https://t.co/AzCAdH8f3m https://t.co/IEltYBRgb5
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⏰ More #Basic #Science in the #Special edition of #OAC⏰ Sandhu et al found that MiRNA and #metabolite profiles were modified by time and by sex early after #ACL reconstruction surgery. @SchroederInst @SandhuAmit90 @jaschahal 🔗 https://t.co/R6PNnROTiB https://t.co/PWSUv4zJcG