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Mashup Score: 275
Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS-1, self-reactive T cells escape thymic …
Source: www.nejm.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 1
Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes amon…
Source: www.nejm.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2
One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from lef…
Source: www.nejm.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 284
The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical even…
Source: www.nejm.orgCategories: General Medicine News, CardiologistsTweet-
Very honored to write the editorial for the trials of two siRNA therapeutics advancing genetically-informed therapeutic hypotheses for lipids and coronary artery disease https://t.co/h1SBe2h4N3 @NEJM Ballantyne et al (plozasiran) https://t.co/zVi9m7x1Jl Rosenson et al… https://t.co/q7Tx9i1eiq https://t.co/ymOmmlrAl6
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Mashup Score: 45
A data survey of 1.8 million people in Nebraska showed that XBB.1.5 vaccine effectiveness was 52% against infection and 67% against hospitalization, despite a decline in circulating XBB.1.5 during …
Source: www.nejm.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 101
The U.S. Supreme Court is considering a case involving penalties targeting involuntary homelessness. Enabling the criminalization of homelessness could undermine individual and population health.
Source: www.nejm.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 24Learning to Say Goodbye | NEJM - 2 day(s) ago
A pediatrician caring for patients with a rare and life-limiting disease learns from his mentor the benefits of acknowledging that his story and his patients’ stories are inextricably intertwined.
Source: www.nejm.orgCategories: General Medicine News, PediatricsTweet
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Mashup Score: 44Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia | NEJM - 2 day(s) ago
Persons with mixed hyperlipidemia are at risk for atherosclerotic cardiovascular disease due to an elevated non–high-density lipoprotein (HDL) cholesterol level, which is driven by remnant choleste…
Source: www.nejm.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3To Preround or Not to Preround | NEJM - 2 day(s) ago
This feature about an attending preparing for her upcoming week of service offers a case vignette accompanied by two essays, one supporting visiting patients early in the morning, before rounds, an…
Source: www.nejm.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 35
The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical even…
Source: www.nejm.orgCategories: General Medicine News, Expert PicksTweet
In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and led to a trial of ruxolitinib in five patients, who had dramatic responses. Read the full study results: https://t.co/tWXykOMI59 https://t.co/f05fK0FZvF