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Mashup Score: 23Reversal of Direct Oral Anticoagulants (DOACs) for Critical Bleeding or Urgent Procedures - 18 day(s) ago
The advent of direct-acting oral anticoagulants (DOACs) has transformed the care of patients requiring prevention and treatment for thrombotic disease. Many randomized clinical trials have demonstrated the efficacy and safety of these agents and their comparative advantages over conventional anticoagulants such as vitamin K antagonists (VKAs). While historically clinicians and patients raised questions about the reversal of DOAC-associated bleeding, federal approval in recent years of targeted DOAC reversal agents, along with adjunctive modalities, has given clinicians reliable pharmacologic options. Yet, optimal reversal strategies for bleeding at specific anatomic locations and in specific clinical scenarios remains uncertain. We present here a narrative review of the literature on the reversal of DOAC-associated bleeding or for urgent procedures. The totality of the reversal literature synthesized here yields several clear conclusions: (1) targeted DOAC reversal with specific agents
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 13Investigating the Relationship Between Ultra-Processed Food Consumption and Academic Performance in the Adolescent Population: The EHDLA Study - 18 day(s) ago
Background: Previous studies have tested the link between diet quality and academic performance in the young population. However, no study has analyzed the specific relationship between ultra-processed food (UPF) consumption and academic performance in adolescents. The aim of the present study was to test the link of UPF consumption with academic performance in a sample of adolescents from Spain. Methods: This secondary cross-sectional analysis utilized information from 788 youths aged 12–17 participating in the Eating Healthy and Daily Life Activities study. The sample comprised 44.7% boys and 55.3% girls, with a median age of 14.0 years (interquartile range [IQR]: 13.0 to 15.0). The UPF consumption was measured through a self-completed food frequency survey. Academic performance was determined using end-of-year academic records provided by each educational institution. To examine the relationships between these variables, generalized linear models were employed. The models were adjus
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Investigating the Relationship Between Ultra-Processed Food Consumption and Academic Performance in the Adolescent Population: The EHDLA Study https://t.co/DwPc6Mxua9
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Mashup Score: 40Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice - 19 day(s) ago
Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were previously clarified in model mice [Ednrb(+/−);RET-mice]. External treatment with luteolin, but not that with hesperetin or diosmetin, alleviated hair graying in Ednrb(+/−);RET-mice. Internal treatment with luteolin also mitigated hair graying in the mice. Although both luteolin treatments had very limited effects on hair cycles, the treatments suppressed the increase in p16ink4a-positive cells in bulges [senescent keratinocyte stem cells (KSCs)]. Both of the treatments also suppressed decreases in the expression levels of endothelins in KSCs and their receptor (Ednrb) in melanocyte stem cells (MSCs) and alleviated hair graying in the mice. Luteolin is a special antioxidant with an anti-graying potency through improvement of age-related dysfun
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
#Luteolin, an antioxidant in vegetables like celery and broccoli, shows potential in preventing hair graying by preserving melanocyte activity, offering a promising avenue for anti-aging hair care solutions. @NagoyaUniv_info https://t.co/RQb2WshZYb https://t.co/CyEz5I0nfF
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Mashup Score: 19
Background: In recent years, juicing has often been promoted as a convenient way to increase fruit and vegetable intake, with juice-only diets marketed for digestive cleansing and overall health improvement. However, juicing removes most insoluble fiber, which may diminish the health benefits of whole fruits and vegetables. Lower fiber intake can alter the microbiota, affecting metabolism, immunity, and mental health, though little is known about juicing’s specific effects on the microbiota. This study addresses this gap by exploring how juicing impacts gut and oral microbiome composition in an intervention study. Methods: Fourteen participants followed one of three diets—exclusive juice, juice plus food, or plant-based food—for three days. Microbiota samples (stool, saliva, and inner cheek swabs) were collected at baseline, after a pre-intervention elimination diet, immediately after juice intervention, and 14 days after intervention. Moreover, 16S rRNA gene amplicon sequencing was us
Source: www.mdpi.comCategories: General Medicine News, General NewsTweet-
#A three-day #Juice-only diet may disrupt gut and oral microbiomes, increasing inflammation-linked bacteria. Including fiber is crucial for maintaining microbial balance and overall health. @northwesternu https://t.co/y9urPFtrY3 https://t.co/MtLzceNith
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Mashup Score: 0Frequency of Common and Uncommon BRAF Alterations among Colorectal and Non-Colorectal Gastrointestinal Malignancies - 19 day(s) ago
Background: The predictive and prognostic role of BRAF alterations has been evaluated in colorectal cancer (CRC); however, BRAF alterations have not been fully characterized in non-CRC gastrointestinal (GI) malignancies. In the present study, we report the frequency and spectrum of BRAF alterations among patients with non-CRC GI malignancies. Methods: Patients with CRC and non-CRC GI malignancies who underwent somatic tumor profiling via a tissue-based or liquid-based assay were included in this study. Gain-of-function BRAF alterations were defined as pathogenic/likely pathogenic somatic short variants (SVs), copy number amplifications ≥8, or fusions (RNA or DNA). Results: Among 51,560 patients with somatic profiling, 40% had CRC and 60% had non-CRC GI malignancies. BRAF GOF alterations were seen more frequently in CRC (8.9%) compared to non-CRC GI malignancies (2.2%) (p < 0.001). Non-CRC GI malignancies with the highest prevalence of BRAF GOF alterations were bile duct cancers (4.1%)
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Frequency of Common and Uncommon BRAFAlterations among Colorectal and Non-Colorectal Gastrointestinal Malignancies [May 10, 2024] @Amitmahipal79 et al. Cancers https://t.co/xONNaih4nc #PrecisionMedicine #crcsm #esocsm #hpbcsm #pancsm #sbcsm #stcsm https://t.co/yLlU6NFS1J
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Mashup Score: 84
Fibromyalgia (FM) is a chronic condition characterized by generalized musculoskeletal pain associated with other symptoms, especially sleep and mood disorders, fatigue, and cognitive dysfunctions. The etiopathogenesis of FM is not sufficiently known, and regardless of numerous research, the clinical presentation is nonspecific, which makes it difficult to approve a timely diagnosis and, subsequently, an adequate therapeutic approach. Genetic, hormonal, immunological, and environmental factors are cited as potential factors in the development of this condition. Diagnosis is based on a clinical approach and known diagnostic criteria, while additional methods, such as radiographic, magnetic resonance, or laboratory analyses, can be useful to exclude other conditions. The heterogeneity of FM significantly impacts both diagnosis and treatment, as it presents a wide spectrum of symptoms that vary in severity, combinations, and underlying contributing factors. This variability is a challenge
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Full read review and overview of Fibromyalgia - manifestations, pathophysiology, treatments and guidelines. Multidisciplinary, patient-centered treatment should includes a combination of pharmacological and nonpharmacological options. https://t.co/Go5T9pN6wH https://t.co/CIXai9OhZd
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Mashup Score: 11Venous Thromboembolism in Patients with Neuroendocrine Neoplasms: A Systematic Review of Incidence, Types, and Clinical Outcomes - 23 day(s) ago
Background: Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors with unique biological characteristics and complications, including thromboembolism. This systematic review evaluates the incidence, types, and clinical outcomes of venous thromboembolic events (VTEs) in NEN patients. Methods: A systematic search of PubMed, Scopus, and Embase was conducted to identify studies on TEs in NENs. Eligible studies included case reports, case series, and retrospective cohort studies reporting VTEs, including deep vein thrombosis (DVT), pulmonary embolism (PE), and visceral vein thrombosis (VVT). Data were extracted on tumor site, functionality, differentiation grade, and VTE type. Results: In total, 33 studies were included, comprising 26 case reports, 2 case series, and 5 retrospective cohort studies. VTE prevalence ranged from 7.5% to 33% across studies. The most common VTEs were DVT, PE, and portal vein thrombosis (PVT). A meta-analysis revealed a pooled VTE prevalence of 11.1%
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Want to know more about venous thromboembolism in patients with neuroendocrine neoplasms...? If so, @saramassironi and @GervasoLorenzo have you covered... https://t.co/Uv0ReL5Cvl
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Mashup Score: 0Frequency of Common and Uncommon BRAF Alterations among Colorectal and Non-Colorectal Gastrointestinal Malignancies - 24 day(s) ago
Background: The predictive and prognostic role of BRAF alterations has been evaluated in colorectal cancer (CRC); however, BRAF alterations have not been fully characterized in non-CRC gastrointestinal (GI) malignancies. In the present study, we report the frequency and spectrum of BRAF alterations among patients with non-CRC GI malignancies. Methods: Patients with CRC and non-CRC GI malignancies who underwent somatic tumor profiling via a tissue-based or liquid-based assay were included in this study. Gain-of-function BRAF alterations were defined as pathogenic/likely pathogenic somatic short variants (SVs), copy number amplifications ≥8, or fusions (RNA or DNA). Results: Among 51,560 patients with somatic profiling, 40% had CRC and 60% had non-CRC GI malignancies. BRAF GOF alterations were seen more frequently in CRC (8.9%) compared to non-CRC GI malignancies (2.2%) (p < 0.001). Non-CRC GI malignancies with the highest prevalence of BRAF GOF alterations were bile duct cancers (4.1%)
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Frequency of Common and Uncommon BRAFAlterations among Colorectal and Non-Colorectal Gastrointestinal Malignancies [May 10, 2024] @Amitmahipal79 et al. Cancers https://t.co/xONNaih4nc #PrecisionMedicine #crcsm #esocsm #hpbcsm #pancsm #sbcsm #stcsm https://t.co/yLlU6NFS1J
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Mashup Score: 4Combining Colchicine and Antiplatelet Therapy to Tackle Atherothrombosis: A Paradigm in Transition? - 26 day(s) ago
Atherothrombosis, the primary driver of acute cardiovascular (CV) events, is characterized by the activation of three key pathophysiological pathways: platelets, coagulation, and inflammation. Dual antiplatelet therapy (DAPT) is the current standard of care for patients with acute coronary syndrome, providing significant reductions in cardiovascular (CV) events, albeit with an associated increased risk of bleeding. However, the high residual risk of recurrent events among these patients highlights the need for alternative strategies to treat and prevent atherothrombosis. To this extent, several approaches aimed at targeting atherothrombosis have been proposed. Among these, a strategy of dual-pathway inhibition simultaneously targeting platelets, using single or DAPT, and coagulation, using a low-dose anticoagulant such as rivaroxaban 2.5 mg twice daily, has shown to reduce CV events but at the expense of increased bleeding. Targeting inflammatory pathways has the potential to be a high
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet-
Combining Colchicine and Antiplatelet Therapy to Tackle Atherothrombosis: A Paradigm in Transition? by Salvatore Giordano et al https://t.co/IT89nTcEjn https://t.co/SAnb5Rw8TZ
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Mashup Score: 17Heterogeneity in Cancer - 26 day(s) ago
Cancer heterogeneity is a major challenge in oncology, complicating diagnosis, prognostication, and treatment. The clinical heterogeneity of cancer, which leads to differential treatment outcomes between patients with histopathologically similar cancers, is attributable to molecular diversity manifesting through genetic, epigenetic, transcriptomic, microenvironmental, and host biology differences. Heterogeneity is observed between patients, individual metastases, and within individual lesions. This review discusses clinical implications of heterogeneity, emphasizing need for personalized approaches to overcome challenges posed by cancer’s diverse presentations. Understanding of emerging molecular diagnostic and analytical techniques can provide a view into the multidimensional complexity of cancer heterogeneity. With over 90% of cancer-related deaths associated with metastasis, we additionally explore the role heterogeneity plays in treatment resistance and recurrence of metastatic les
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Pleased to share latest review manuscript by @BrownUniversity alum, former #eldeirylab member William J. MacDonald et al. on Heterogeneity in Cancer https://t.co/fvGSbBvgC0 #LegorretaCancerCenter @BrownUCancer @BrownMedicine @BrownUniversity @BrownUnivHealth @connorfpurcell
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Reversal of Direct Oral Anticoagulants (DOACs) for Critical Bleeding or Urgent Procedures https://t.co/nO4UccEUXU #mdpijcm via @JCM_MDPI @Vasculearn @AnticoagForum @ThrombosisCan @canvector @EuropeanTHA @ThrombosisUK @TromboseLeiden @PERTConsortium @thrombosisday @escardio https://t.co/CQAKY7KU23