Cardiovascular disease (CVD) is the leading cause of death in women.1 Alarmingly, CVD rates are increasing among younger women ≤ 55 yr.2–4 Increased rates of disease track with a worrisome trend of an increasing prevalence of CVD risk factors among young adults over the past decade.5,6 Given the overwhelming evidence from genetic, observational, and interventional studies that low-density lipoprotein cholesterol (LDL-C) and other apolipoprotein B (apoB)-containing particles are causally related to atherosclerotic CVD (ASCVD) pathogenesis,7 lipid management remains a central tenet for ASCVD prevention across major professional society guidelines.