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Mashup Score: 0Will we need water in the hospitals of the future? The role of water vs. waterless systems - 6 hour(s) ago
Healthcare is one of the largest users of water in the UK and treats those most likely to acquire infection from environmental sources. With strict environmental controls in place healthcare-acquired Legionella pneumophila is rare in the UK, 14 cases in England and Wales in 20201. However, Gram-negative bacteria, such as Pseudomonas aeruginosa, some multiresistant, are often present in sink and shower drains and may be spread via staff or patient contact to other patients. Other organisms such as Stenotrophomonas sp, Burkholderia sp, Cupravidus sp and nontuberculous mycobacteria are emerging as waterborne pathogens.
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Mashup Score: 3Effect of prolonged exposure to disinfectants in the antimicrobial resistance profile of relevant microorganisms: a systematic review - 11 hour(s) ago
Antimicrobial resistance (AMR) constitutes a major global health threat, to a very large extent due to the inadequate use of antibiotics. Additionally, the misuse of disinfectants can also trigger the selection of resistant clones, where microorganisms develop an adaptative response and progress to resistance mechanisms. Cross-resistance may occur when biocides selective pressure induce antimicrobial resistance. This study intends to acknowledge the potential relationship between repeated and/or prolonged exposure to disinfectants and antimicrobial resistance profile adjustment.
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Mashup Score: 1Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy - 2 day(s) ago
Standardised efficacy surface tests for disinfectants are performed on pristine surfaces. There is a growing interest in understanding the impact of surface ageing on disinfectant activity, owing for example to the increased usage of UV radiation and oxidative chemistries for surface decontamination. This acknowledges that general surface “wear and tear” following UV radiation and oxidative biocide exposure may impact biocidal product efficacy.
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Mashup Score: 13
The role of the healthcare environment in the transmission of clinical pathogens is well established. We investigated the chemical stability and sporicidal efficacy of oxidising disinfectant products in the presence of simulated clean and medical dirty conditions.Performance of chlorine-releasing agents (sodium dichloroisocyanurate, chlorine dioxide and hypochlorous acid) was concentration-dependent, with 1000 ppm chlorine showing reduced stability and efficacy in dirty conditions. In contrast peracetic acid product demonstrated stability and consistently achieved efficacy in dirty conditions.
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Mashup Score: 7Qualitative research methods: Powerful tools for understanding practice and informing change - 7 day(s) ago
We currently exist in an era of unprecedented and increasing data. This era of data proliferation is particularly acute for health and medicine, which, as critical aspects of social funding, are saturated with knowledge. Yet much of the data produced is not actually utilised in service of better care. With the rise of AI, our ability to access information generated globally and examine large sets of data has never been greater. However, data volume versus data depth has become an emerging problem, and so too has the local relevance and authenticity of data.
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Mashup Score: 3
Healthcare associated infections (HAI) remain a global health challenge and have elevated rates in Sub-Saharan Africa. HAIs impact patients and their families by causing illness, prolonged hospital stay, potential disability, excess costs and sometimes death. The costs of HAI are increasing due to spreading antimicrobial resistance. A major risk factor for HAIs is lack of water, sanitation, and hygiene (WASH), environmental cleaning and healthcare waste management. In Sub-Saharan Africa these services are lacking in at least 50% of healthcare facilities.
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Mashup Score: 7ML-based risk assessment tool to rule out empiric use of ESBL-targeted therapy in endemic areas - 9 day(s) ago
Antimicrobial stewardship focuses on identifying patients who require ESBL-targeted therapy. Rule-in tools have been extensively researched in areas of low endemicity; however, such tools are inadequate for areas with high rates of ESBL, as almost all patients will be selected.
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Mashup Score: 6
The first British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS)-endorsed faecal microbiota transplant (FMT) guidelines were published in 2018. Over the past 5 years, there has been considerable growth in the evidence base (including publication of outcomes from large national FMT registries), necessitating an updated critical review of the literature and a second edition of the BSG/HIS FMT guidelines. These have been produced in accordance with National Institute for Health and Care Excellence-accredited methodology, thus have particular relevance for UK-based clinicians, but are intended to be of pertinence internationally.
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Mashup Score: 8Development and Evaluation of Test Methods for the Detection and Enumeration of Opportunistic Waterborne Pathogens from the Hospital Environment - 12 day(s) ago
Many Gram -negative bacteria other than Pseudomonas aeruginosa have been implicated in waterborne outbreaks but standardised laboratory detection methods for these organisms have not been established.
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Mashup Score: 3Short Versus Prolonged Duration of Therapy for Pseudomonas aeruginosa Bacteremia: A Systematic Review and Meta-analysis - 13 day(s) ago
The optimal duration of therapy for Pseudomonas aeruginosa bloodstream infection (PSA-BSI) is unknown, with prolonged therapy frequently favored due to severity of infection, patient complexity, risk of multi-drug resistance, and high mortality. We therefore conducted a systematic review and meta-analysis of studies with head-to-head comparison of short versus prolonged therapy for PSA-BSI.
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Will we need water in the hospitals of the future? The role of water vs. waterless systems https://t.co/EosM8iruPl