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Mashup Score: 96New Concepts on the Pathophysiology of Acute Coronary Syndrome - 15 day(s) ago
Acute coronary syndrome (ACS) is the most severe form of ischemic heart disease. Although it is caused by atherosclerotic plaque thrombosis or nonatherosclerotic causes, its pathophysiological mechanism of ACS is not fully understood, and its concept is constantly updated and developed. At present, the main pathophysiological mechanisms include plaque rupture, plaque erosion, calcified nodules (CN) and non-atherosclerotic causes such as coronary vasospasm and myocardial bridging (MB). These mechanisms may overlap and coexist in some ACS patients. Therefore, the pathophysiological mechanism of ACS is complex, and is of great significance for the diagnosis and treatment of ACS. This review will discuss the pathophysiological mechanisms of ACS to provide new thoughts on the pathogenesis, diagnosis and treatment of ACS.
Source: www.imrpress.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Efficacy and Safety of Deferred Stenting in Geriatric Patients with STEMI and High Thrombus Burden - 2 month(s) ago
Background: Deferred stenting has been recognized as beneficial for patients with acute ST-segment elevation myocardial infarction (STEMI) accompanied by a high thrombus burden. Nevertheless, its efficacy and safety specifically in geriatric STEMI patients remain to be elucidated. This study aims to bridge this knowledge gap and assess the potential advantages of deferred stenting in an older patient cohort. Methods: In this study, 208 geriatric patients (aged ≥80 years) with STEMI and a high thrombus burden in the infarct-related artery (IRA) were enrolled. They were categorized into two groups: the deferred stenting group, where stent implantation was conducted after 7–8 days of continuous antithrombotic therapy, and the immediate stenting group, where stent implantation was performed immediately. Results: In the deferred stenting group, the stents used were significantly larger in diameter and shorter in length compared to those in the immediate stenting group (p < 0.05). This group
Source: www.imrpress.comCategories: General Medicine News, CardiologistsTweet-
Deferred stenting for geriatric patients with STEMI and high thrombus burden demonstrates significant clinical benefits. It reduces distal embolism in the IRA, but also enhances myocardial tissue perfusion and preserves cardiac ejection function https://t.co/20DDiTnQ4q
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Mashup Score: 21Cardiac Sarcoidosis: A Comprehensive Clinical Review - 3 month(s) ago
Sarcoidosis is an inflammatory multisystemic disease of unknown etiology characterized by the formation of non-caseating granulomas. Sarcoidosis can affect any organ, predominantly the lungs, lymphatic system, skin and eyes. While >90% of patients with sarcoidosis have lung involvement, an estimated 5% of patients with sarcoidosis have clinically manifest cardiac sarcoidosis (CS), whereas approximately 25% have asymptomatic, clinically silent cardiac involvement verified by autopsy or imaging studies. CS can present with conduction disturbances, ventricular arrhythmias, heart failure or sudden cardiac death. Approximately 30% of <60-year-old patients presenting with unexplained high degree atrioventricular (AV) block or ventricular tachycardia are diagnosed with CS, therefore CS should be strongly considered in such patients. CS is the second leading cause of death among patients affected by sarcoidosis after pulmonary sarcoidosis, therefore its early recognition is important, because
Source: www.imrpress.comCategories: General Medicine News, Hem/OncsTweet-
RT @ZHeart11768530: 🔴 Cardiac Sarcoidosis: A Comprehensive Clinical #2024Review #openaccess https://t.co/0ubCj7Lch3 #cardiology #CardioTw…
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Mashup Score: 19Novel Targeted Therapies for Rheumatoid Arthritis Based on Intracellular Signalling and Immunometabolic Changes: A Narrative Review - 4 month(s) ago
Rheumatoid arthritis (RA) is a relatively common systemic autoimmune disease with an estimated prevalence of approximately 1% worldwide. Patients present predominantly with symmetrical small joint inflammatory arthritis, which involves dysregulated immune responses, leading to bone and cartilage deformities due to extensive erosive damage. The introduction of biological based therapies for the management of this life-altering condition, over the past three decades, has led to marked improvements in patients’ quality of life. A wide range of both innate and adaptive immune cells are involved in the pathogenesis of RA, with a complex interplay of cytokines, T-cells, B-cells, and dendritic cells. Some of these cells have been successfully targeted in the treatment of RA by the use of biologics-based therapies. For example, rituximab therapy blocks B cell activation and abatacept effectively blocks T cell activation in patients with RA. Despite these advances, there remain some patients wh
Source: www.imrpress.comCategories: General Medicine News, RheumatologyTweet-
🌟New!🌟 📢Novel targeted therapies for #RheumatoidArthritis based on intracellular signalling & immunometabolic changes Proud to be part of this collaborative paper on #rheumatoid 👉🏽https://t.co/Zjnived7DC via @Landmark_IMR https://t.co/pEIZndz8Nm
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Mashup Score: 12Closing the Gaps in Care of Dyslipidemia: Revolutionizing Management with Digital Health and Innovative Care Models - 5 month(s) ago
Although great progress has been made in the diagnostic and treatment options for dyslipidemias, unawareness, underdiagnosis and undertreatment of these disorders remain a significant global health concern. Growth in digital applications and newer models of care provide novel tools to improve the management of chronic conditions such as dyslipidemia. In this review, we discuss the evolving landscape of lipid management in the 21st century, current treatment gaps and possible solutions through digital health and new models of care. Our discussion begins with the history and development of value-based care and the national establishment of quality metrics for various chronic conditions. These concepts on the level of healthcare policy not only inform reimbursements but also define the standard of care. Next, we consider the advances in atherosclerotic cardiovascular disease risk score calculators as well as evolving imaging modalities. The impact and growth of digital health, ranging fro
Source: www.imrpress.comCategories: General Medicine News, CardiologistsTweet-
Closing the Gaps in Care of Dyslipidemia: Revolutionizing Management with Digital Health and Innovative Care Models - neat article @HopkinsMedicine @CiccaroneCenter @SethShayMartin @khurramn1 https://t.co/k4Ni371GxE
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Mashup Score: 1
Background: Biventricular pacing (BVP) is recommended for patients with heart failure (HF) who require cardiac resynchronization therapy (CRT). Left bundle branch area pacing (LBBAP) is a novel pacing strategy that appears to ensure better electrical and mechanical synchrony in these patients. Our aim was to systematically review and meta-analyze the existing evidence regarding the clinical outcomes of LBBAP-CRT compared with BVP-CRT. Methods: Medline, Embase, Cochrane Central Register of Controlled Trials and Web of Science databases were searched for studies comparing LBBAP-CRT with BVP-CRT. Outcomes were all-cause mortality, heart failure hospitalizations (HFH) and New York Heart Association (NYHA) class improvement. We included randomized controlled trials (RCTs) and observational studies with participants that had left ventricular ejection fraction (LVEF) ≤40% and (i) symptomatic HF or (ii) expected ventricular pacing >40%. Random and fixed effects models pairwise meta-analysis wa
Source: www.imrpress.comCategories: General Medicine News, CardiologistsTweet-
Sparse robust evidence I’m afraid, but we suggest that compared with BVP-CRT, receipt of LBBAP-CRT in patients with #heartfailure is associated with ⬇️ risk of mortality & heart failure hospitalisation, & ⬆️ NHYA class. Please be mindful of limitations. https://t.co/cf3SfJoqCf
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Mashup Score: 23
Takotsubo Syndrome (TS) is an acute, reversible cardiac dysfunction, with complex, not entirely understood pathophysiology and heterogeneous clinical picture. Imaging methods each have a crucial role in the diagnosis, in-hospital management, short term and long term follow up. Coronary angiography needs to be performed, especially in the setting of a suspected acute coronary syndrome, in order to rule out coronary artery disease. Echocardiography plays a central role both in the acute and the chronic phase. It is the first imaging investigation performed in patients with TS, valuable to diagnose systolic dysfunction, the wall motion pattern and early complications. Cardiac magnetic resonance tissue characterization provides an essential role in the differential diagnosis of TS with other non-ischemic causes of systolic dysfunction. This review focuses on the imaging methods and the important part they play in the complex management of the disease.
Source: www.imrpress.comCategories: General Medicine News, CardiologistsTweet-
RT @ZHeart11768530: 🧩Review on Imaging Diagnosis Methods in Takotsubo Syndrome🖍️ https://t.co/qV8Chg6HJi #Takotsubo_Syndrome #Imaging #ACS…
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Mashup Score: 16Amiodarone in ventricular arrhythmias: still a valuable resource? - 6 month(s) ago
Ventricular arrhythmias still represent an important cause of morbidity and mortality, especially in patients with heart failure and reduced left ventricular ejection fraction. Amiodarone is a Class III Vaughan-Williams anti-arrhythmic drug widely used in ventricular arrhythmias for its efficacy and low pro-arrhythmogenic effect. On the other hand, a significant limitation in its use is represented by toxicity. In this review, the pharmacology of the drug is discussed to provide the mechanistic basis for its clinical use. Moreover, all the latest evidence on its role in different clinical settings is provided, including the prevention of sudden cardiac death, implanted cardioverter defibrillators, ischemic and non-ischemic cardiomyopathies. A special focus is placed on everyday clinical practice learning points, such as dosage, indications, and contraindications from the latest guidelines.
Source: www.imrpress.comCategories: General Medicine News, CardiologistsTweet-
RT @ZHeart11768530: Amiodarone in ventricular arrhythmias: still a valuable resource?@RCMjournal https://t.co/ZSn0HIVoIZ #cardiology #Cardi…
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Mashup Score: 4Cardiovascular Imaging in the Evaluation of Athletes with Physiological Cardiac Remodelling and Cardiovascular Diseases - 1 year(s) ago
Cardiovascular Imaging in the Evaluation of Athletes with Physiological Cardiac Remodelling and Cardiovascular Diseases
Source: www.imrpress.comCategories: Cardiologists, Latest HeadlinesTweet-
Dear colleagues, our Special Issue "Cardiovascular Imaging in the Evaluation of Athletes with Physiological Cardiac Remodelling and Cardiovascular Diseases" is open. The deadline for submitting your paper is: 30 June! For more information: https://t.co/gwy0qJ5lSe @El_Cavarretta https://t.co/FgxgqrlX54
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Mashup Score: 14
IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to making positive contributions to academics, corporate libraries as well as to readers and authors. All the editors in IMR Press…
Source: www.imrpress.comCategories: Expert Picks, Latest HeadlinesTweet-
Please consider submitting an article to our special Global Go Red edition on global differences in ACS #Cardiotwitter @ShrillaB @aayshacader IF=4.4 @drsonyaburgess @cardioPCImom @iamritu @mirvatalasnag @cpachecoMD @Hragy @mmamas1973 @AnastasiaSMihai https://t.co/pA9rukxQL1
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RT @ZHeart11768530: 🔴New Concepts on the Pathophysiology of Acute Coronary Syndrome #OpenAccess #Review https://t.co/0uNkrDKQHW #CardioEd…