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Mashup Score: 35
Background Following the 2022–2023 mpox outbreak, crucial knowledge gaps exist regarding orthopoxvirus-specific immunity in risk groups and its impact on future outbreaks. Aim We combined cross-sectional seroprevalence studies in two cities in the Netherlands with mathematical modelling to evaluate scenarios of future mpox outbreaks among men who have sex with men (MSM). Methods Serum samples were obtained from 1,065 MSM attending Centres for Sexual Health (CSH) in Rotterdam or Amsterdam following the peak of the Dutch mpox outbreak and the introduction of vaccination. For MSM visiting the Rotterdam CSH, sera were linked to epidemiological and vaccination data. An in-house developed ELISA was used to detect vaccinia virus (VACV)-specific IgG. These observations were combined with published data on serial interval and vaccine effectiveness to inform a stochastic transmission model that estimates the risk of future mpox outbreaks. Results The seroprevalence of VACV-specific antibodies wa
Source: www.eurosurveillance.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 98Neonatal Elizabethkingia anophelis meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024 - 8 month(s) ago
Elizabethkingia anophelis is a multidrug-resistant pathogen causing high mortality and morbidity in adults with comorbidities and neonates. We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family’s residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.
Source: www.eurosurveillance.orgCategories: General Medicine News, General HCPsTweet-
Yikes: Dutch infant develops #meningitis caused by a bacteria resistant to multiple antibiotics. Apparent source was contaminated water in an automated infant milk dispenser, though where the water came from is unclear. Authors warn more cases could occur. https://t.co/ZkB6Tne7xC
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Mashup Score: 15
Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.
Source: www.eurosurveillance.orgCategories: General Medicine News, Infectious DiseaseTweet-
RT @1986Bom: Peer reviewed manuscript is now also available online: https://t.co/fsTHlmdYau It is very important to continue this work sin…
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Mashup Score: 222023/24 mid-season influenza and Omicron XBB.1.5 vaccine effectiveness estimates from the Canadian Sentinel Practitioner Surveillance Network (SPSN) - 9 month(s) ago
The Canadian Sentinel Practitioner Surveillance Network reports mid-season 2023/24 influenza vaccine effectiveness (VE) of 63% (95% CI: 51–72) against influenza A(H1N1)pdm09, lower for clade 5a.2a.1 (56%; 95% CI: 33–71) than clade 5a.2a (67%; 95% CI: 48–80), and lowest against influenza A(H3N2) (40%; 95% CI: 5–61). The Omicron XBB.1.5 vaccine protected comparably well, with VE of 47% (95% CI: 21–65) against medically attended COVID-19, higher among people reporting a prior confirmed SARS-CoV-2 infection at 67% (95% CI: 28–85).
Source: www.eurosurveillance.orgCategories: General Medicine News, General HCPsTweet-
6. A study from Canada gives mid-season estimates of how well #flu & #Covid vaccines are working. Flu vax has been pretty effective against H1N1 viruses w/ a vaccine efficacy of 63%; H3N2's was lower, around 40%. But H3 hasn't been a big player this year. https://t.co/h2nz2ULOM4 https://t.co/51fCimhjrb
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Mashup Score: 181Detection of Crimean–Congo haemorrhagic fever virus in Hyalomma marginatum ticks, southern France, May 2022 and April 2023 - 9 month(s) ago
Crimean–Congo haemorrhagic fever (CCHF), a potentially severe zoonotic viral disease causing fever and haemorrhagic manifestations in humans. As the Crimean–Congo haemorrhagic fever virus (CCHFV) has been detected in ticks in Spain and antibodies against the virus in ruminant sera in Corsica, it was necessary to know more about the situation in France. In 2022–2023, CCHFV was detected in 155 ticks collected from horses and cattle in southern France.
Source: www.eurosurveillance.orgCategories: General Medicine News, Infectious DiseaseTweet-
Quite high rate of ticks positive for crimean congo hemorrhagic fever virus in southern france. Another pathogen to keep a close eye on https://t.co/fY3iDGuAtF
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Mashup Score: 292Identification of a measles variant displaying mutations impacting molecular diagnostics, Geneva, Switzerland, 2023 - 10 month(s) ago
Real-time PCR is one of the most widely used techniques to diagnose measles cases. Here we report measles virus variants with three genetic mutations in the reverse primer annealing site of a widely used PCR. The mutations result in a slight loss of the PCR sensitivity. Variants bearing the three mutations presently circulate in different countries since at least the end of 2021. Our findings highlight the usefulness of molecular surveillance in monitoring if oligonucleotides in diagnostic tests remain adequate.
Source: www.eurosurveillance.orgCategories: General Medicine News, Infectious DiseaseTweet-
#Measles are re-emerging & reliable laboratory diagnosis is of importance: Research at our centre @gcevd @hug_ge @UNIGEnews has identified a mutated variant impacting molecular diagnostics! Great work by F. Perez-Rodriguez & colleagues @Eurosurveillance https://t.co/qXPIY7t8qZ
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Mashup Score: 290Identification of a measles variant displaying mutations impacting molecular diagnostics, Geneva, Switzerland, 2023 - 10 month(s) ago
Real-time PCR is one of the most widely used techniques to diagnose measles cases. Here we report measles virus variants with three genetic mutations in the reverse primer annealing site of a widely used PCR. The mutations result in a slight loss of the PCR sensitivity. Variants bearing the three mutations presently circulate in different countries since at least the end of 2021. Our findings highlight the usefulness of molecular surveillance in monitoring if oligonucleotides in diagnostic tests remain adequate.
Source: www.eurosurveillance.orgCategories: General Medicine News, Infectious DiseaseTweet-
#Measles are re-emerging & reliable laboratory diagnosis is of importance: Research at our centre @gcevd @hug_ge @UNIGEnews has identified a mutated variant impacting molecular diagnostics! Great work by F. Perez-Rodriguez & colleagues @Eurosurveillance https://t.co/qXPIY7t8qZ
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Mashup Score: 44Impact of nirsevimab prophylaxis on paediatric respiratory syncytial virus (RSV)-related hospitalisations during the initial 2023/24 season in Luxembourg - 10 month(s) ago
After Luxembourg introduced nirsevimab immunisation against respiratory syncytial virus (RSV), estimated neonatal coverage was 84% (1,277 doses/1,524 births) in 2023. That year, paediatric RSV-related hospitalisations, especially concerning infants < 6 months old (n = 72) seemed to decrease compared to the same period in 2022 (n = 232). In 2023, hospitalised children’s mean age increased (14.4 months vs 7.8 months in 2022; p < 0.001) and hospital-stay length decreased (3.2 days vs 5.1 days; p < 0.001). In infants < 6 months old, intensive-care unit admissions appeared to drop (n = 28 vs 9). This suggests that nirsevimab prophylaxis reduced severe RSV infections, particularly in infants < 6 months old, thereby alleviating healthcare strain.
Source: www.eurosurveillance.orgCategories: General Medicine News, General HCPsTweet-
3. Nirsevimab seemed to alter the age distribution of cases. There was a dramatic cut in the total number of #RSV hospitalization days, from ~2,000 to 771. Nirsevimab was in short supply in the US this winter but this bodes well for future RSV control. https://t.co/6YFhNZavM3 https://t.co/OlXHlWmGEc
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Mashup Score: 292Early influenza vaccine effectiveness estimates using routinely collected data, Alberta, Canada, 2023/24 season - 10 month(s) ago
Timely and precise influenza vaccine effectiveness (VE) estimates are needed to guide public health messaging and impact vaccine uptake immediately. Using routinely collected laboratory, vaccination and health administrative data from Alberta, Canada, we estimated influenza VE against infection for the 2023/24 season on a near real-time basis, to late December, at 61% (95% CI: 58–64) against influenza A(H1N1), 49% (95% CI: 28–63) against influenza A(H3N2) and 75% (95% CI: 58–85) against influenza B.
Source: www.eurosurveillance.orgCategories: General Medicine News, General HCPsTweet-
1. Canadian researchers publish the first estimates of 2023-24 #flu vaccine effectiveness that I've seen to date, in @Eurosurveillanc. The VE is pretty good — 61% overall against H1N1, which was responsible for the vast majority of cases. https://t.co/jnjA5TG70m
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Mashup Score: 1Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020 - 10 month(s) ago
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well as sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the impact of sex and gender on PASC in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients and hospitalised patients with PCR-confirmed SARS-CoV-2 infection. Results Among those who remained outpatients during their first infection, women reported persisting symptoms more often than men (40.5% vs 25.5% of men; p < 0.001). This sex difference was absent in hospitalised patients. In a crude analysis, both female biological sex (RR = 1.59; 95% CI: 1.41–1.79; p < 0.001) and a score summarising gendered sociocultural variables (RR = 1.05; 95% CI: 1.03–1.07; p < 0.001) were significantly associated with PASC. Following multivariab
Source: www.eurosurveillance.orgCategories: General Medicine News, PayerTweet-
RT @Crof: Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020 https://t.co/t8O4WBFyvi
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Mpox: Using a mathematical model, we demonstrated that the 2022 vaccination campaign, while only having a negligible effect on the Dutch 2022-23 outbreak itself, would result in a distinct reduction of the size and duration of future outbreaks.https://t.co/aHRBOniObD