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Mashup Score: 5Tripe palm: a paraneoplastic manifestation of gastric cancer - 10 month(s) ago
A 73-year-old man presented with a warty thickening of the skin on his hands and feet, which had been present for more than 1 year. He also reported general weakness, poor appetite and a weight loss of 8 kg over 6 months. The palms of his hands and soles of his feet had a rugose appearance with a
Source: www.cmaj.caCategories: General Medicine News, General HCPsTweet
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Mashup Score: 20Advances in the management of renal cell carcinoma - 10 month(s) ago
KEY POINTS Renal cell carcinoma (RCC) is the 10th most common cancer in Canada, with an estimated 8100 new cases and 1950 deaths from the disease annually.[1][1] Renal cell carcinoma accounts for more than 90% of kidney malignancies. Its incidence increases with age, with a global median age at
Source: www.cmaj.caCategories: General Medicine News, Partners & KOLsTweet-
Trying to stay up to date in #kidneycancer? Check out this review in @CMAJ that I'm thrilled to have contributed to with @lalaniMD (my @theviewongu co-host) and the @McMasterU @JuravinskiRI team: https://t.co/sL6eDdBb6M @KidneyCancer @KidneyCancer_Ca @CanUrolAssoc
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Mashup Score: 20Advances in the management of renal cell carcinoma - 10 month(s) ago
KEY POINTS Renal cell carcinoma (RCC) is the 10th most common cancer in Canada, with an estimated 8100 new cases and 1950 deaths from the disease annually.[1][1] Renal cell carcinoma accounts for more than 90% of kidney malignancies. Its incidence increases with age, with a global median age at
Source: www.cmaj.caCategories: General Medicine News, Partners & KOLsTweet-
Trying to stay up to date in #kidneycancer? Check out this review in @CMAJ that I'm thrilled to have contributed to with @lalaniMD (my @theviewongu co-host) and the @McMasterU @JuravinskiRI team: https://t.co/sL6eDdBb6M @KidneyCancer @KidneyCancer_Ca @CanUrolAssoc
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Mashup Score: 19Advances in the management of renal cell carcinoma - 10 month(s) ago
KEY POINTS Renal cell carcinoma (RCC) is the 10th most common cancer in Canada, with an estimated 8100 new cases and 1950 deaths from the disease annually.[1][1] Renal cell carcinoma accounts for more than 90% of kidney malignancies. Its incidence increases with age, with a global median age at
Source: www.cmaj.caCategories: General Medicine News, Partners & KOLsTweet-
Trying to stay up to date in #kidneycancer? Check out this review in @CMAJ that I'm thrilled to have contributed to with @lalaniMD (my @theviewongu co-host) and the @McMasterU @JuravinskiRI team: https://t.co/sL6eDdBb6M @KidneyCancer @KidneyCancer_Ca @CanUrolAssoc
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Mashup Score: 1Differential effect of ticagrelor versus clopidogrel by homocysteine levels on risk of recurrent stroke: a post hoc analysis of the CHANCE-2 trial - 11 month(s) ago
Background: Elevated homocysteine levels are associated with increased blood coagulation and platelet activity and may modulate the response to antiplatelet therapies. We aimed to investigate the effects of homocysteine levels on the efficacy and safety of ticagrelor–acetylsalicylic acid (ASA) versus clopidogrel–ASA among patients with minor stroke or transient ischemic attack who carried CYP2C19 loss-of-function alleles. Methods: We conducted a post hoc analysis of the CHANCE-2 (The Clopidogrel in High-risk Patients with Acute Nondisabling Cerebrovascular Events–II) trial. Participants were randomly assigned to treatment with ticagrelor–ASA or clopidogrel–ASA. We categorized participants into groups with elevated and non-elevated homocysteine levels, based on the median level. The primary efficacy outcome was recurrent stroke within 90-day follow-up. The primary safety outcome was severe or moderate bleeding within 90 days. Results: A total of 2740 participants were randomly assigned
Source: www.cmaj.caCategories: General Medicine News, Partners & KOLsTweet-
Differential effect of ticagrelor versus clopidogrel by homocysteine levels on risk of recurrent stroke: a post hoc analysis of the CHANCE-2 trial https://t.co/GCtbMC8DCS
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Mashup Score: 5Diagnosis and management of endometriosis - 1 year(s) ago
[For a first-person account of endometriosis, see www.cmaj.ca/lookup/doi/10.1503/cmaj.230215][1] KEY POINTS Endometriosis is a chronic condition defined by the presence of endometrial-like tissue outside of the uterus, which can lead to estrogen-driven inflammation. The extent of disease can be
Source: www.cmaj.caCategories: General Medicine News, Hem/OncsTweet-
Diagnosis and management of endometriosis https://t.co/K9usAhLsF4 via @DrAllaire et al https://t.co/rze9JUsQzu
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Mashup Score: 2
KEY POINTS Despite serious disruptions to tuberculosis (TB) programs during the COVID-19 pandemic, including in Canada,[1][1] the past few years have also seen global advances in TB treatment. Novel drugs and regimens have been developed to support faster, safer, more effective treatment for drug-
Source: www.cmaj.caCategories: General Medicine News, Hem/OncsTweet-
Time for Canada to align with global innovations in treatment for tuberculosis https://t.co/2sZxS0qAHI via @HealthLawAdamH et al
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Mashup Score: 9Neonatal lupus erythematosus - 1 year(s) ago
A 5-week-old infant boy presented to the dermatology department with a 3-week history of annular plaques. The patient had multiple papules and annular plaques with a raised border on his scalp and face ([Figure 1][1]). His mother had an uncomplicated pregnancy, although she had a history of systemic
Source: www.cmaj.caCategories: General Medicine News, PediatricsTweet-
RT @NICU_Musings: Rash present in a 5 week old for 3 weeks leads to maternal diagnosis. The heart was ok... https://t.co/wvuNfPntur #neoTwi…
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Mashup Score: 396
Background: Population-based cross-sectional serosurveys within the Lower Mainland, British Columbia, Canada, showed about 10%, 40% and 60% of residents were infected with SARS-CoV-2 by the sixth (September 2021), seventh (March 2022) and eighth (July 2022) serosurveys. We conducted the ninth (December 2022) and tenth (July 2023) serosurveys and sought to assess risk of severe outcomes from a first-ever SARS-CoV-2 infection during intersurvey periods. Methods: Using increments in cumulative infection-induced seroprevalence, population census, discharge abstract and vital statistics data sets, we estimated infection hospitalization and fatality ratios (IHRs and IFRs) by age and sex for the sixth to seventh (Delta/Omicron-BA.1), seventh to eighth (Omicron-BA.2/BA.5) and eighth to ninth (Omicron-BA.5/BQ.1) intersurvey periods. As derived, IHR and IFR estimates represent the risk of severe outcome from a first-ever SARS-CoV-2 infection acquired during the specified intersurvey period. Resu
Source: www.cmaj.caCategories: General Medicine News, Expert PicksTweet-
As of July 2023, in British Columbia, 21% of people were seronegative Covid (Novids), nearly double (~40%) among people age 80+. The risk of death and hospitalization for advanced age groups is substantial https://t.co/brr5HPs1Ng @CMAJ https://t.co/ADsDMPoknu
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Mashup Score: 1
Background: Higher doses of opioids, mental health comorbidities, co-prescription of sedatives, lower socioeconomic status and a history of opioid overdose have been reported as risk factors for opioid overdose; however, the magnitude of these associations and their credibility are unclear. We sought to identify predictors of fatal and nonfatal overdose from prescription opioids. Methods: We systematically searched MEDLINE, Embase, CINAHL, PsycINFO and Web of Science up to Oct. 30, 2022, for observational studies that explored predictors of opioid overdose after their prescription for chronic pain. We performed random-effects meta-analyses for all predictors reported by 2 or more studies using odds ratios (ORs) and 95% confidence intervals (CIs). Results: Twenty-eight studies (23 963 716 patients) reported the association of 103 predictors with fatal or nonfatal opioid overdose. Moderate- to high-certainty evidence supported large relative associations with history of overdose (OR 5.85
Source: www.cmaj.caCategories: General Medicine News, General HCPsTweet-
CMAJ analysis of 28 studies & 24 million pts Rx opioids suggest a higher risk of opioid overdose w/: high-dose opioids, fentanyl, multiple opioid Rxs, overdose Hx, Dx of substance use, depression, bipolar, mental illness, pancreatitis https://t.co/FprgoaTvXR https://t.co/G0QjNJTezu
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You let me down yesterday. I tweeted this from a pt, "My arms are beginning to look like tripe..." Nobody on this site suggested the diagnosis of tripe palm. Thankfully I am married to a dermatologist. Up your game #MedTwitter! https://t.co/pfm6db1QTY