• Mashup Score: 69
    City of Hope scientists develop targeted chemotherapy able to kill all solid tumors in preclinical research - 9 month(s) ago

    The City of Hope-developed investigational small molecule selectively disrupts DNA replication and repair in cancer cells, leaving healthy cells unaffected, a new study reports. CONTACT Zen Logsdon 626-409-9367zlogsdon@coh.org The City of Hope-developed small molecule AOH1996 targets a cancerous variant of the protein  PCNA. In its mutated form, PCNA is critical in DNA replication and repair of all expanding tumors. Here we see untreated cancer cells (left) and cancer cells treated with AOH1996 (right) undergoing programmed cell death (violet). (Photo credit: City of Hope)LOS ANGELES — Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research. As the scientists conti

    Source: www.cityofhope.org
    Categories: Latest Headlines, Oncologists2
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      pashtoonkasi

      What is the #CityOfHopeDrug? A pill💊that can kill all #cancers. I have been asked the "killer-pill" question several times this week. What is the hope or the hype? Let’s learn together: 👇Here’s a tweetorial: @OncoAlert Press release: August 1, 2023: https://t.co/9ajG9oYgqM https://t.co/o5HNKEgIAp

  • Mashup Score: 0
    Cancer Center Announces First Patient Has Received City of Hope’s Novel, Potentially Cancer-Stopping Pill - 9 month(s) ago

    CONTACT Zen Logsdon 626-409-9367 zlogsdon@coh.org The Phase 1 clinical trial tests the safety of providing City of Hope-developed AOH1996 to people with reoccurring solid tumors. LOS ANGELES — City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced that the first patient to receive its novel, promising cancer medicine AOH1996 is doing well. The Phase 1 clinical trial testing the safety of a potentially cancer-stopping therapeutic developed by City of Hope in people with reoccurring solid tumors is expected to continue for the next two years. The investigational pill has been effective in preclinical research treating cells derived from breast, prostate, brain, ovarian, cervical, skin and lung cancers. Linda Malkas, Ph.D., professor in City of Hope’s Department of Molecular Diagnostics & Experimental Therapeutics, has been working on the research and subsequent discovery and development of AOH1996 for 20 years. AOH1996 is named

    Source: www.cityofhope.org
    Categories: Hem/Oncs, Latest Headlines
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      weldeiry

      Cancer Center Announces First Patient Has Received City of Hope’s Novel, Potentially Cancer-Stopping Pill https://t.co/vybdNDpCnB

  • Mashup Score: 0
    World Cancer Day: Your Cancer Care, Your Community - 2 year(s) ago

    World Cancer Day: Your Cancer Care, Your Community

    Source: www.cityofhope.org
    Categories: Hem/Oncs, Latest Headlines
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      DrEdKim

      Today, on World Cancer Day – and every day - @CityofHope Orange County is committed to advancing access to world-renowned cancer research and treatment. Learn what we are doing to close the care gap that affects almost everyone. #worldcancerday2022 https://t.co/RXI7wkVBiP

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    By the Slimmest of Margins - 3 year(s) ago

    Jim Belardi and his wife Leslie are making a transformative gift, representing the largest single contribution for blood cancer research, to support City of Hope’s Hematologic Malignancies Research Institute (HMRI.) The gift will accelerate progress on promising new therapies for some of the most difficult-to-treat blood cancers — cancers like the one Belardi survived.

    Source: www.cityofhope.org
    Categories: Hem/Oncs, Latest Headlines
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      montypal

      >@CityofHope to accelerate blood cancer research thanks to a generous gift from leukemia survivor James Belardi and his wife Leslie Belardi. https://t.co/WjbpYdpzkH #CityofHope #CancerResearch #BloodCancerAwareness https://t.co/eIwUXIvI21

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