Several factors make small bowel bleeding (SBB) increasingly common in clinical practice. Medical advances have extended the lives of patients with advanced comorbidities including chronic kidney disease, cirrhosis, heart failure, valvular heart disease, pulmonary hypertension, vascular occlusive disease, and myelodysplasia, all of which are associated with SBB, particularly from small bowel angioectasias (SBAEs). Furthermore, the use and potency of antithrombotic agents are increasing. At the same time, the wide use of anti-secretory therapy, efforts to identify and eradicate H. pylori infection, and increases in colorectal cancer screening and diagnostic upper endoscopy have decreased the incidence of other sources of gastrointestinal (GI) bleeding such as peptic ulcer disease and malignancy.

Early-onset colorectal cancer (EO-CRC), diagnosed before age 50, is rising in incidence worldwide. Although post-surgical colonoscopy surveillance strategies exist, appropriate intervals in EO-CRC remain elusive, as long-term surveillance outcomes remain scant. We sought to compare findings of surveillance colonoscopies of EO-CRC with patients with average onset colorectal cancer (AO-CRC) to help define surveillance outcomes in these groups.

Although the burden of alcohol-associated hepatocellular carcinoma (HCC) is increasing with rising alcohol consumption, clinical presentation and outcomes of alcohol-associated HCC have not been systematically assessed. We aimed to determine the prevalence, clinical characteristics, surveillance rates, treatment allocation, and outcomes of alcohol-associated HCC.