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Mashup Score: 0Multi-Region Brain Organoid –Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components - 18 day(s) ago
Brain organoid technology has revolutionized our ability to model human neurodevelopment in vitro. However, current techniques remain limited by their reliance on simplified endothelial cell populations rather than a complete endothelial system. We engineered Multi-Region Brain Organoids (MRBOs) that integrate cerebral, mid/hindbrain, and complex endothelial organoids into one structure. Different from the earlier approaches based on isolated HUVECs, our endothelial organoids contain diverse vascular cell types, including vascular progenitors, mature endothelial cells, pericytes, proliferating angiogenic cells and stromal cells. Our strategy employs a sequential modulation of key developmental pathways to generate individual organoids, followed by optimized fusion conditions that maintain regional identities while supporting cellular integration. Single-nucleus RNA sequencing shows that MRBOs develop discrete neural populations specific to each brain region alongside specialized endoth
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3Developmental Biology | bioRxiv - 22 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet-
New papers posted on August 13, 2024: 5 in developmental biology: https://t.co/eZVOXSRa3m 2 in ecology: https://t.co/G27yHyrNIx 2 in evolutionary biology: https://t.co/0k6EOYGNAt 1 in genetics: https://t.co/dzLSXauFuh 1 in immunology: https://t.co/I7DRZezf0S
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Mashup Score: 0Bioengineering | bioRxiv - 22 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet-
New papers posted on August 27, 2024: 3 in bioengineering: https://t.co/kBN3UQ7DR4 10 in bioinformatics: https://t.co/dNiMwyEYbJ 7 in biophysics: https://t.co/WExV4x2xPK 9 in cancer biology: https://t.co/7DXtDVhlLd 6 in cell biology: https://t.co/vO1EPg76bW
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Mashup Score: 2Physiology | bioRxiv - 22 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet-
New papers posted on August 23, 2024: 4 in physiology: https://t.co/fUCeEWiiwP 5 in plant biology: https://t.co/rbZpRa3Xcg 1 in synthetic biology: https://t.co/NvtWK7Xiza 1 in systems biology: https://t.co/bu5SvDBxLG 2 in zoology: https://t.co/RLzIlMVkMR
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Mashup Score: 3Immunology | bioRxiv - 22 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General Journals & SocietTweet-
New papers posted on August 14, 2024: 1 in immunology: https://t.co/I7DRZezf0S 8 in microbiology: https://t.co/uVMmwwTmD4 1 in molecular biology: https://t.co/CnFa1ZO18j 2 in neuroscience: https://t.co/ES0ayAHKiZ 1 in synthetic biology: https://t.co/NvtWK7Xiza
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Mashup Score: 4UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design - 23 day(s) ago
The P2X7 receptor is an ATP-gated ion channel that activates inflammatory pathways involved in diseases such as cancer, atherosclerosis, and neurodegeneration. However, despite the potential benefits of blocking overactive signaling, no P2X7 receptor antagonists have been approved for clinical use. Interspecies variation among existing antagonists has proven challenging, in part due to the dearth of molecular information on different receptor orthologs. Here, to identify distinct molecular features in the human receptor, we determine high-resolution cryo-EM structures of the full-length wild-type human P2X7 receptor in apo closed and ATP-bound open state conformations and draw comparisons with new and existing structures of other orthologs. We also report a cryo-EM structure of the human receptor in complex with an adamantane-based inhibitor, which we leverage, in conjunction with functional data and molecular dynamics simulations, to design a potent and selective antagonist with a uni
Source: www.biorxiv.orgCategories: General Medicine News, CardiologistsTweet-
RT @mansoor_steven: Excited to share our latest work on bioRxiv: https://t.co/P0iOUDru69 I am very proud of this project because working…
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Mashup Score: 2Animal Behavior and Cognition | bioRxiv - 26 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General HCPsTweet-
New papers posted on August 17, 2024: 1 in animal behavior and cognition: https://t.co/7tQS0oPK0z 5 in biochemistry: https://t.co/4CFfZtfFY0 2 in bioengineering: https://t.co/kBN3UQ7DR4 11 in bioinformatics: https://t.co/dNiMwyEYbJ 7 in biophysics: https://t.co/WExV4x2xPK
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Mashup Score: 2Genomics | bioRxiv - 26 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General Journals & SocietTweet-
New papers posted on August 16, 2024: 13 in genomics: https://t.co/Z37SNmzQpX 6 in immunology: https://t.co/I7DRZezf0S 11 in microbiology: https://t.co/uVMmwwTmD4 4 in molecular biology: https://t.co/CnFa1ZO18j 25 in neuroscience: https://t.co/ES0ayAHKiZ
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Mashup Score: 3Biophysics | bioRxiv - 26 day(s) ago
bioRxiv – the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Source: www.biorxiv.orgCategories: General Medicine News, General Journals & SocietTweet-
New papers posted on August 14, 2024: 3 in biophysics: https://t.co/WExV4x2xPK 1 in cancer biology: https://t.co/7DXtDVhlLd 6 in cell biology: https://t.co/vO1EPg76bW 2 in evolutionary biology: https://t.co/0k6EOYGNAt 1 in genetics: https://t.co/dzLSXauFuh
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Mashup Score: 1Benchmarking DNA Sequence Models for Causal Regulatory Variant Prediction in Human Genetics - 26 day(s) ago
Machine learning holds immense promise in biology, particularly for the challenging task of identifying causal variants for Mendelian and complex traits. Two primary approaches have emerged for this task: supervised sequence-to-function models trained on functional genomics experimental data and self-supervised DNA language models that learn evolutionary constraints on sequences. However, the field currently lacks consistently curated datasets with accurate labels, especially for non-coding variants, that are necessary to comprehensively benchmark these models and advance the field. In this work, we present TraitGym, a curated dataset of regulatory genetic variants that are either known to be causal or are strong candidates across 113 Mendelian and 83 complex traits, along with carefully constructed control variants. We frame the causal variant prediction task as a binary classification problem and benchmark various models, including functional-genomics-supervised models, self-supervis
Source: www.biorxiv.orgCategories: General Medicine News, Hem/OncsTweet-
Benchmarking DNA Sequence Models for Causal Regulatory Variant Prediction in Human Genetics https://t.co/Tv0J2NGOdQ via @gsbenegas et al https://t.co/EGg7EXlZ6I
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https://t.co/mewBY7U7Oq