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Mashup Score: 3
Rationale: The use of hydrocortisone in adult patients with septic shock is controversial, and the effectiveness of adding fludrocortisone to hydrocortisone remains uncertain. Objectives: To assess…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0
Rationale: The use of hydrocortisone in adult patients with septic shock is controversial, and the effectiveness of adding fludrocortisone to hydrocortisone remains uncertain. Objectives: To assess…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2Climate Change - 6 hour(s) ago
The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is issuing a call for papers: “Climate Change: Cellular and Molecular Mechanisms Impacting Lung Pathobiology.” This call aims to showcase work that investigate the mechanisms by which environmental climate change-related factors impact lung health and disease either directly, or through interaction with other elements (e.g., ozone, PM2.5, allergens, pathogens). The Journal welcomes Original Research, Perspectives, Major Technical
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction - 6 hour(s) ago
Intrauterine growth restriction (IUGR) is characterized by fetal weight below the 10th percentile per gestational age, increased risk for various conditions, and premature death (1). Infants with IUGR are at an increased risk of the development of pulmonary hypertension (PH), a devastating condition characterized by increased pulmonary artery pressures and remodeling of the pulmonary vasculature (1). Among the potential causes of IUGR-associated PH is the arrested development of the pulmonary vascular
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 1
Current international guidelines for the management of septic shock, based on moderate-quality evidence, suggest the use of corticosteroids for adults with an ongoing requirement for vasopressor therapy (1). Although the beneficial effect of systemic corticosteroids on the duration of shock may be established, their effect on mortality seems less certain (2, 3). A recent patient-level meta-analysis concluded that corticosteroids (specifically hydrocortisone) were not associated with reduced mortality
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 4Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 3 day(s) ago
Newborns with intrauterine growth restriction (IUGR) have a higher likelihood of developing pulmonary arterial hypertension (PAH) in adulthood. Although there is increasing evidence suggesting that…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6
Rationale: Maternal obstructive sleep apnea–hypopnea (OSAH) is associated with hypertensive disorders of pregnancy (HDP). OSAH treatment with positive airway pressure (PAP) in the general populatio…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 5Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry - 3 day(s) ago
Rationale: Chronic obstructive pulmonary disease (COPD) due to tobacco smoking commonly presents when extensive lung damage has occurred. Objectives: We hypothesized that structural change would be…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 3A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma - 3 day(s) ago
Rationale: Density thresholds in computed tomography (CT) lung scans quantify air trapping (AT) at the whole-lung level but are not informative for AT in specific bronchopulmonary segments. Objecti…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2
Our view of chronic obstructive pulmonary disease (COPD) has dramatically shifted over the past 20 years. We began the millennium with the National Emphysema Treatment Trial and added lung volume reduction surgery as a disease-modifying therapy to the treatment of COPD (1). In 2015, we observed that in a randomized, double-blind placebo-controlled trial, augmentation therapy for α1 antitrypsin deficiency resulted in a statistically significant slowing of the progression of emphysema (2). Finally, large
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials đź”— https://t.co/5gaXBXGszO https://t.co/JIww6du8BU