Two recent studies published in Nature by Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD). They identified specific cell subtypes and cell–cell interactions that correlate with distinct clinical outcomes, thus providing valuable…

Identifying predictive biomarkers of immune-related adverse events (irAEs) is crucial to maximize the benefits for patients with cancer treated with immune checkpoint inhibitors (ICIs). In a recent study published in Med, Nuñez et al. utilized multi-omics approaches and identified blood immune signatures that have the potential to predict the development of autoimmune toxicity.