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Mashup Score: 0
Based on a statistically significant, clinically meaningful improvement in overall survival compared with gemcitabine and cisplatin without any new safety signals, pembrolizumab plus gemcitabine and cisplatin could be a new treatment option for patients with previously untreated metastatic or unresectable biliary tract cancer.
Source: The LancetCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 6
WHO is unusual within the UN system in having a strong regional structure. Every 5 years all of WHO’s member states meet at the World Health Assembly in Geneva, Switzerland to elect a Director-General. Each member state is also a member of one of WHO’s six regions, which in turn elect Regional Directors.
Source: The LancetCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
“There are many health-related issues that transcend WHO's regional borders but do not need to be addressed at the global level.” A Comment from @martinmckee—Working together across WHO's regions in an increasingly complex world: https://t.co/ExCdwzCDMe
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Mashup Score: 17Improving health outcomes of people with diabetes: target setting for the WHO Global Diabetes Compact - 1 year(s) ago
The Global Diabetes Compact is a WHO-driven initiative uniting stakeholders around goals of reducing diabetes risk and ensuring that people with diabetes have equitable access to comprehensive, affordable care and prevention. In this report we describe the development and scientific basis for key health metrics, coverage, and treatment targets accompanying the Compact. We considered metrics…
Source: The LancetCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Global estimates indicate that 537 million adults have diabetes. In a new Health Policy, Edward W Gregg & colleagues propose and define metrics and targets for the Global Diabetes Compact to stimulate global action: https://t.co/yXPsT0PgiJ https://t.co/NwVBk29x8W
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Mashup Score: 0
Targeting CLDN18.2 with zolbetuximab significantly prolonged progression-free survival and overall survival when combined with mFOLFOX6 versus placebo plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma. Zolbetuximab plus mFOLFOX6 might represent a new first-line treatment in these…
Source: The LancetCategories: Gastroenterology, Latest HeadlinesTweet-
New @TheLancet - Zolbetuximab + mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT) https://t.co/a56MFLBSCY #gitwitter #onctwitter #gastriccancer https://t.co/L4rZUqrdrP
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Mashup Score: 8Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial - 1 year(s) ago
Ritlecitinib was effective and well tolerated in patients aged 12 years and older with alopecia areata. Ritlecitinib might be a suitable treatment option for alopecia areata in patients who are candidates for systemic therapy.
Source: The LancetCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Ritlecitinib might be a treatment option for alopecia areata in patients aged 12 years and older, suggests a new study: https://t.co/jKUxEbo4AZ Below, a graphical abstract 👇 https://t.co/JIJtTGHeE4
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Mashup Score: 0
Based on a statistically significant, clinically meaningful improvement in overall survival compared with gemcitabine and cisplatin without any new safety signals, pembrolizumab plus gemcitabine and cisplatin could be a new treatment option for patients with previously untreated metastatic or unresectable biliary tract cancer.
Source: The LancetCategories: Hem/Oncs, Latest HeadlinesTweet-
KEYNOTE-966 and TOPAZ-1 are so similar: ⚡️mOS: KN966: 12.7 vs 10.9 mos, HR: 0.83 T1: 12.8 vs 11.5 mos, HR: 0.80 ⚡️ORR: KN966: 29% vs. 28% T1: 27% vs 19% Key Takeaways: 👉 anti-PD-1 is weakly effective in BTCs. 👉 Continue gem in maintenance #AACR2023 https://t.co/4Di4zFWac6
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Mashup Score: 4
Based on a statistically significant, clinically meaningful improvement in overall survival compared with gemcitabine and cisplatin without any new safety signals, pembrolizumab plus gemcitabine and cisplatin could be a new treatment option for patients with previously untreated metastatic or unresectable biliary tract cancer.
Source: The LancetCategories: Hem/Oncs, Latest HeadlinesTweet-
Congrats and thanks! Always a delight to have more options! Pembrolizumab + gemcitabine and cisplatin v. gemcitabine and cisplatin alone for patients with BTC (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial https://t.co/8RamjD4IjT
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Mashup Score: 1Renzo Guinto: creating resilient planetary systems for health - 1 year(s) ago
Towards the end of 2019, Ramon Lorenzo Luis Rosa Guinto completed his doctorate in public health at Harvard University in the USA, and, in early 2020, returned home to the Philippines. His arrival coincided with the emergence of COVID-19, which, Guinto feels, “was very timely. When a global health crisis happens, that’s when you’re needed in your home country”. In 2012, Guinto had graduated with…
Source: The LancetCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
“It's about making health systems more resilient and sustainable, but also creating planetary systems for health that involve other sectors.” A Profile of @RenzoGuinto: https://t.co/NKQGCLKyht
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Mashup Score: 3Differential diagnosis of blue toes in a newborn baby: might have been maternal infection with COVID-19? - 1 year(s) ago
A newborn baby girl with blueish-coloured skin lesions on the tips of the first, second, and fourth toes of her right foot was brought to our unit 12 h after birth (figure). Apart from the noted abnormalities, the patient was healthy; she was normally alert and showing no clinical signs of pain. The respiratory rate was between 40 and 50 breaths per min, oxygen saturation was over 95% on room…
Source: The LancetCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A newborn baby girl presented with blueish-coloured skin lesions on the tips of three toes on her right foot 12 h after birth. No familial predisposition to thromboembolic events or autoimmune diseases was reported. Explore the case 👉 https://t.co/9uW7Cf0Co7
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Mashup Score: 2
In the field of global health, attempts to promote equitable practices have been curtailed by entrenched power asymmetries.1 Among 2000 board seats of the most influential organisations in global health, 75% are held by nationals of high-income countries (HICs), home to 16% of the global population. Fewer than 1%—just 17 board seats—are held by women from low-income countries.2 These findings…
Source: The LancetCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
“In the field of global health, attempts to promote equitable practices have been curtailed by entrenched power asymmetries.” @sewankam & colleagues propose three positive disruptions to dislodge the old narrative of global health: https://t.co/hDbo7mLvZh
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New @TheLancet - Kelley et al - Pembrolizumab plus gemcitabine and cisplatin vs gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966) https://t.co/ZbdRQwzSuW #gitwitter #onctwitter https://t.co/PwoNAduQxK