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Mashup Score: 3BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA-mutant ovarian cancer - 11 month(s) ago
In PARP inhibitor–resistant BRCA-mutant ovarian cancer, biomarkers of replication stress and fork stability predict response to CHK1 inhibitors.
Source: Science Translational MedicineCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 22Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody - 11 month(s) ago
A protective pan-hantavirus antibody engages a quaternary epitope on the viral surface glycoprotein to lock it in a pre-fusion conformation.
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 2
Understanding the varied mechanisms of resistance to venetoclax helps uncover how they can be therapeutically targeted.
Source: Science Translational MedicineCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 13Contents | Science Translational Medicine 15, 684 - 1 year(s) ago
Science Translational Medicine Volume 15|Issue 684|22 Feb 2023 ONLINE COVER TACKling HIV. The cover image shows a crystal structure of a targeted activator of cell kill (TACK) molecule (gray, purple, blue, and light blue spheres) bound to the p66 subunit (orange and green ribbon) of the human immunodeficiency virus (HIV)–1 reverse transcriptase (RT). The p51 subunit is…
Source: Science Translational MedicineCategories: Expert Picks, Latest HeadlinesTweet
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Mashup Score: 3Contents | Science Translational Medicine 14, 669 - 2 year(s) ago
Science Translational Medicine Volume 14|Issue 669|2 Nov 2022 ONLINE COVER Pathological Pathways in Heart Failure. Shown is an immunofluorescence microscopy image of human dilated left ventricle heart tissue stained for TRIM35 (magenta), troponin-I (green), wheat germ agglutinin (red), and nuclei (blue). Lorenzana-Carrillo et al. observed that the ubiquitin ligase TRIM35 is…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 4Contents | Science Translational Medicine 14, 668 - 2 year(s) ago
Science Translational Medicine Volume 14|Issue 668|26 Oct 2022 ONLINE COVER Putting Antibodies on the Map. This image shows three antibodies in red, orange, and yellow targeting distinct epitopes on the Lassa Virus (LASV) glycoprotein complex (GPC, blue). The virion surface is shown in green. LASV remains a major target for vaccine and therapeutic design, but the structural…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 6Contents | Science Translational Medicine 14, 664 - 2 year(s) ago
Science Translational Medicine Volume 14|Issue 664|28 Sep 2022 ONLINE COVER Abating Breast Biopsies. The cover depicts a woman’s torso with a breast tumor that can be detected by a magnetic resonance imaging (MRI) machine. Due to its high specificity, dynamic contrast-enhanced MRI (DCE-MRI) is sometimes used to screen women at increased risk of breast cancer, although this…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 4Contents | Science Translational Medicine 14, 663 - 2 year(s) ago
Science Translational Medicine Volume 14|Issue 663|21 Sep 2022 ONLINE COVER Overcoming ESR1 Activation. Shown is a carmine alum staining of ductal patterns from whole murine mammary glands of wild type (left) and activating Esr1-mutant (right) mice. The dark structures at the center of the glands are lymph nodes. Liang et al. employed the mouse mammary gland to examine…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 4Contents | Science Translational Medicine 14, 662 - 2 year(s) ago
Science Translational Medicine Volume 14|Issue 662|14 Sep 2022 ONLINE COVER A Sticky Situation. The image shows a Staphylococcus aureus bacterial biofilm adhered to plastic. Biofilms hinder antibiotic penetration and constitute a clinical challenge. Building on work showing that an added glycopeptide group improved vancomycin potency against Gram-positive bacteria,…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 6Contents | Science Translational Medicine 14, 659 - 2 year(s) ago
Science Translational Medicine Volume 14|Issue 659|24 Aug 2022 ONLINE COVER Genetically Attenuated Parasites. The cover image shows a color-enhanced light micrograph of ring-stage Plasmodium falciparum (yellow), one of the species of Plasmodium that causes malaria in humans, inside of a human erythrocyte. A safe and effective malaria vaccine is essential to curb the…
Source: Science Translational MedicineCategories: Future of Medicine, Latest HeadlinesTweet
BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA-mutant ovarian cancer @ScienceMagazine https://t.co/VnrjonFZVG