MashupMD

Mashup Score: 0

Fibromyalgia and mortality: a systematic review and meta-analysis - 10 month(s) ago

Objective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis. Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words ‘fibromyalgia’ and ‘mortality’ to identify studies that addressed an association between fibromyalgia and mortality. Original papers that…

Source: RMD Open

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  Metanalysis of 8 RCT, 188751 pts assessed mortality risk & FM. Overall, all-cause mortality increased in FM (HR 1.27, 1.04 to 1.51), but not in subgroup Dx by 1990 criteria. Increased SMR for accidents, infxn, suicide & decreased for cancer (0.82) https://t.co/Ujv8KP8FJK https://t.co/lNGUM0wB3O

Mashup Score: 3

Validation of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in an academic tertiary care centre - 10 month(s) ago

Objectives To assess the sensitivity and specificity of the 2019 EULAR/American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) in outpatients at an academic tertiary care centre and to compare them to the 1997 ACR and the 2012 Systemic Lupus International Collaborating Clinics criteria. Methods Prospective and retrospective observational cohort…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  Assessment of 2019 EULAR/ACR classification criteria for #SLE: 👍more sensitive than the 1997 criteria 👎but less specific. ☝️most sensitive, but least specific items: 👉history of ANA 👉detection of dsDNA antibodies. Read more deatils here ➡️ https://t.co/EFab9lcGts

Mashup Score: 9

NF-kappa-B essential modulator (NEMO) gene polymorphism in an adult woman with systemic lupus erythematosus and recurrent non-tuberculous mycobacterial disseminated infections - 10 month(s) ago

Infections are among the most serious complications in patients with systemic lupus erythematosus (SLE), with bacterial and viral infections being the most common. Non-tuberculous mycobacterial (NTM) infections are quite rare and are typically seen in older patients with SLE with longstanding disease duration treated with corticosteroids. Here, we describe a 39-year-old woman with SLE and an…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  🦠Recurrent non-tuberculous mycobacterial disseminated infections due to homozygous NF-kappa-B essential modulator (NEMO) gene polymorphism 🧬 ▶️CD4 count & Ig levels normal ▶️neg anti-IFN-gamma Abs ▶️no mutations in IL-12 pathway https://t.co/M4RYMg9IRf @ThrouNeedlesEye https://t.co/hrEXuLOQIX https://t.co/JJo2zRN97L

Mashup Score: 1

Joint involvement in RA starts predominantly in the hands: functional, clinical and imaging studies in clinically suspect arthralgia and during progression to RA - 10 month(s) ago

Objectives It is unknown whether rheumatoid arthritis (RA) starts in hands or feet. To investigate this, we performed functional, clinical and imaging studies during progression from clinically suspect arthralgia (CSA) to RA. Additionally, we studied whether functional disabilities of hands/feet at CSA onset contribute to predicting RA development. Methods 600 patients with CSA were followed for…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  What is earlier in #arthritis development: hand or foot? Check the results of a longitudinal evaluation of arthralgia individuals: ▶️ hand dissabilities occur earlier & more frequently ▶️ decreased hand function added value for risk stratification 🔗 https://t.co/mxvb8SVIYZ https://t.co/FMIvZJoeZ3

Mashup Score: 0

Analysis of serum proteomics data identifies a quantitative association between beta-defensin 2 at baseline and clinical response to IL-17 blockade in psoriatic arthritis - 10 month(s) ago

Objectives Despite several effective targeted therapies, biomarkers that predict whether a patient with psoriatic arthritis (PsA) will respond to a particular treatment are currently lacking. Methods We analysed proteomics data from serum samples of nearly 2000 patients with PsA in placebo-controlled phase-III clinical trials of the interleukin-17 inhibitor secukinumab. To discover predictive…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  What is new on the prediction of response in #psoriatic #arthritis? ▶️ beta-defensin 2 serum levels predicted clinical response upon secukinumab ▶️ early (4 weeks) and sustained (up to 52 weeks) predictive capacity ▶️ also effective with adalimumab 🔗 https://t.co/TvDhMnsAzO https://t.co/qZZqta3AuZ

Mashup Score: 5

Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group - 10 month(s) ago

Objectives To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study. Methods Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b)…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  What is the profile of inflammatory rheumatic diseases developed after #COVID19 infection or vaccination? ▶️ broad spectrum ▶️ inflammatory joint diseases more frequent post-infection ▶️ polymialgia more frequent post-vaccination 🔗 https://t.co/k5YZc5Ji71 https://t.co/kdoaQgyl7b

Mashup Score: 0

Facilitators and barriers for vaccination in patients with inflammatory rheumatic musculoskeletal diseases: a prospective cohort study - 10 month(s) ago

Introduction To identify facilitators and barriers towards vaccination in general and specifically against pneumococci, influenza and SARS-CoV-2 in patients with rheumatic musculoskeletal diseases (RMD). Methods Between February and April 2021, consecutive patients with RMD were asked to complete a structured questionnaire on general knowledge about vaccination, personal attitudes and perceived…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  Which are the barriers and facilitators for vaccination in RMDs? Check out the results of a recent survey: ✅ facilitators: societal and organisational items 🔴 barriers: intrapersonal issues 🔗 https://t.co/9qXKluuWpI https://t.co/8GcUxe8CDV

Mashup Score: 0

Alteration of innate lymphoid cell homeostasis mainly concerns salivary glands in primary Sjögren’s syndrome - 10 month(s) ago

Objective Innate lymphoid cells (ILCs) are a cell population implicated in the pathogenesis of various chronic inflammatory diseases, but little is known about their role in primary Sjögren’s syndrome (pSS). The aim of this study was to assess the frequency of ILC subsets in peripheral blood (PB) and their quantity and location in minor salivary glands (MSGs) in pSS. Methods The frequency of ILC…

Source: RMD Open

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  Interested in Innate Lymphoid Cells? Check out our latest manuscript on Sjögren syndrome: ▶️ ILC1 associated with anti-SSA, ILC3 negatively associated with glandular swelling ▶️ ILC3 frequency elevated in infiltrates in minor salivary gland tissues 🔗 https://t.co/TDj650qRZH https://t.co/ezlKPkqN8M

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Sleep behaviour differs in women and men with psoriatic arthritis and axial spondyloarthritis with impact on quality of life and depressive symptoms - 11 month(s) ago

Objectives Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) may have a profound impact on sleep and health-related quality of life. The aim of this study was to assess sleep quality and quality of life and determine associated factors in patients treated with spondyloarthritides (SpA). Methods Cross-sectional questionnaire-based assessment of sleep behaviour, quality of life,…

Source: RMD Open

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  Study of 162axSpA pts found that 46.6% reported abnormal sleep behavior, worse in Female patients vs males (P <.001). Such pts were more likely to have depression (P = .015) and worse health-related QoL (HRQOL) (P = .015) https://t.co/a1OoUTPKiV https://t.co/gkjkkdljOh

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New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis - 11 month(s) ago

Objective Interleukin (IL)-40 is a new cytokine related to immune system function and malignancies. Recently, an association of IL-40 with rheumatoid arthritis (RA) and externalisation of neutrophil extracellular traps (NETosis) was found. As neutrophils are implicated in RA development, we investigated IL-40 in early stages of RA (ERA). Methods IL-40 was determined in serum of treatment naïve…

Source: RMD Open

Categories: Latest Headlines, Rheumatology

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  📢 New kid on the block: IL-40 ⬆️ elevated in RA serum 🕸 associated with #NETosis markers 🔵 secreted by #neutrophils Find the whole story here👉https://t.co/O9VLril873 #openaccess https://t.co/Fc5WQlC9om