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Mashup Score: 4
Cancer has found a formidable foil in COVID-19, and this has brought to the fore the early concerns that COVID-19 could have a deeper impact on oncology patients. Two studies now provide insights into the enigma surrounding the determinants of the worsening of COVID-19 symptoms in patients with cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 5Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis - Nature Cancer - 2 year(s) ago
Kang and colleagues identify a specific compound blocking MTDH1–SND1 interaction, which prevents metastatic breast cancer progression, induces regression of established metastasis in preclinical models and restores chemosensitivity.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Two studies indicate that small-molecule disruptors of the MTDH–SND1 complex suppress #breastcancer progression, enhance tumour antigen presentation (via stabilization of Tap1/2 mRNAs) & synergizes with anti-PD-1 therapy: https://t.co/uXOfFljyvb & https://t.co/3RaJk44rSn #bcsm
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Mashup Score: 8ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma - Nature Cancer - 2 year(s) ago
In two cohorts of patients with glioblastoma who received anti-PD-1, Sonabend and colleagues show that ERK1/2 phosphorylation, detected by immunohistochemistry, provides a biomarker for MAPK/ERK pathway activity and better survival on this therapy.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
ERK1/2 phosphorylation on IHC is associated with tumour-infiltrating myeloid cell/microglia with elevated expression of MHC class II & associated genes, & was predictive of OS following PD-1 blockade in 2 cohorts of pts with recurrent glioblastoma: https://t.co/XoIi8O0aAQ #BTSM
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Mashup Score: 1ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma - Nature Cancer - 2 year(s) ago
In two cohorts of patients with glioblastoma who received anti-PD-1, Sonabend and colleagues show that ERK1/2 phosphorylation, detected by immunohistochemistry, provides a biomarker for MAPK/ERK pathway activity and better survival on this therapy.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma @NatureCancer https://t.co/Gk1t42EhvB
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Mashup Score: 5ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma - Nature Cancer - 2 year(s) ago
In two cohorts of patients with glioblastoma who received anti-PD-1, Sonabend and colleagues show that ERK1/2 phosphorylation, detected by immunohistochemistry, provides a biomarker for MAPK/ERK pathway activity and better survival on this therapy.
Source: Nature CancerCategories: Hematologists1, Latest HeadlinesTweet-
ERK1/2 phosphorylation - a biomarker for response to anti-PD-1 immunotherapy in recurrent glioblastoma https://t.co/N4mao2gojq
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Mashup Score: 34Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis - Nature Cancer - 2 year(s) ago
Kang and colleagues identify a specific compound blocking MTDH1–SND1 interaction, which prevents metastatic breast cancer progression, induces regression of established metastasis in preclinical models and restores chemosensitivity.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
🔥🔥 ONLINE @NatureCancer: 2 studies from @yibinkang &Co discover MTDH-SND1 inhibitors for metast #BreastCancer therapy via cell- and non-cell-autonomous effects DON'T MISS THEM! 👇 https://t.co/Ma0yXr9evZ https://t.co/Gs8FHOeEjr https://t.co/R6tLerbrzV https://t.co/1iduSbHsT4 https://t.co/ZirvDVPRVr
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Mashup Score: 1
Lehtiö and colleagues perform proteogenomic analysis of non-small cell lung cancer and identify molecular subtypes with distinct immune-evasion mechanisms and therapeutic targets and validate their classification method in separate clinical cohorts.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
MS-based proteogenomic analysis of 141 NSCLCs across all major histologies revealed 6 distinct proteome subtypes with differences in immune cell composition and subtype-specific expression of immune checkpoints https://t.co/0L30Lup7N1
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Mashup Score: 2APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis - Nature Cancer - 2 year(s) ago
Woermann and colleagues describe a deaminase-independent function for APOBEC3A in initiating chromosomal instability and STING-dependent metastasis in human and mouse pancreatic cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @NatRevClinOncol: APOBEC3A induces chromosomal instability in mouse models of pancreatic cancer https://t.co/26z56tpMKh
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Mashup Score: 1APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis - Nature Cancer - 2 year(s) ago
Woermann and colleagues describe a deaminase-independent function for APOBEC3A in initiating chromosomal instability and STING-dependent metastasis in human and mouse pancreatic cancer.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
APOBEC3A induces chromosomal instability in mouse models of pancreatic cancer https://t.co/26z56tpMKh
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Mashup Score: 22Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism - Nature Cancer - 2 year(s) ago
Peinado and colleagues show that small extracellular vesicles and secreted NGFR cargo induce lymphangiogenesis and develop the lymph node pre-metastatic niche to promote melanoma metastasis, which could be targeted pre-clinically with NGFR inhibition.
Source: Nature CancerCategories: Latest Headlines, Oncologists2Tweet-
Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism | Nature Cancer https://t.co/0ZJt04YGyx
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A global effort to understand the riddles of COVID-19 and cancer @NatureCancer @OncoAlert https://t.co/L90bYDYfGO https://t.co/ceoL4eAfRq